Is there a critical target gene for the first step in carcinogenesis?

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

Viral oncogenes

1985 • 605 citations

Relationship between x-ray exposure and malignant transformation in C3H 10T1/2 cells.

1980 • 255 citations

Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteins

1984 • 203 citations

A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene.

1984 • 192 citations

Carcinogen-mediated amplification of viral DNA sequences in simian virus 40-transformed Chinese hamster embryo cells.

1981 • 190 citations

UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.

1984 • 130 citations

Timing of the steps in transformation of C3H 10T½ cells by X-irradiation

1984 • 128 citations

A Point Mutation in the c- myc Locus of a Burkitt Lymphoma Abolishes Binding of a Nuclear Protein

1988 • 102 citations

The Effect of γ Radiation on DNA Methylation

1989 • 102 citations

Inhibition of Oral Carcinogenesis by a Protease Inhibitor<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1986 • 92 citations

Activation of c-myc and c-K-ras Oncogenes in Primary Rat Tumors induced by Ionizing Radiation

1987 • 91 citations

Evidence That a Second Event in X-Ray-Induced Oncogenic Transformation in Vitro Occurs during Cellular Proliferation

1984 • 88 citations

Selective dna‐amplification induced by carcinogens (initiators): Evidence for a role of proteases and DNA polymerase alpha

1985 • 72 citations

The conditions for the modification of radiation transformation in vitro by a tumor promoter and protease inhibitors

1985 • 68 citations

A Transforming ras Gene in Tumorigenic Guinea Pig Cell Lines Initiated by Diverse Chemical Carcinogens

1984 • 67 citations

Investigation of the mechanism for enhancement of radiation transformation in vitro by 12-O-tetradecanoylphorbol-13-acetate

1980 • 58 citations

A serine protease activity in C3H/10T1/2 cells that is inhibited by anticarcinogenic protease inhibitors.

1987 • 54 citations

Inhibition of carcinogen-altered rat tracheal epithelial cell proliferation by normal epithelial cells in vivo

1987 • 50 citations

Assessment of radiogenic cancer initiation frequency per clonogenic rat mammary cell in vivo.

1986 • 43 citations

C-Myc expression is reduced in antipain-treated proliferating C3H 10T12 cells

1985 • 42 citations

Anticarcinogenic Actions of Protease Inhibitors

1987 • 36 citations

The effects of the Bowman-Birk protease inhibitor on c-myc expression and cell proliferation in the unirradiated and irradiated mouse colon

1990 • 34 citations

Potential intracellular target proteins of the anticarcinogenic Bowman Birk protease inhibitor identified by affinity chromatography.

1988 • 33 citations

UV Radiation Facilitates Methotrexate Resistance and Amplification of the Dihydrofolate Reductase Gene in Cultured 3T6 Mouse Cells

1984 • 32 citations

c-fos mRNA levels are reduced in the presence of antipain and Bowman-Birk inhibitor

1989 • 27 citations

Effects of protease inhibitors on c‐myc expression in normal and transformed C3H 10T1/2 cell lines

1990 • 25 citations

Evidence that the first step leading to carcinogen-induced malignant transformation is a high frequency, common event.

1985 • 24 citations

Specific binding of transforming growth factor correlates with promotion of anchorage independence in EGF receptorless mouse JB6 cells

1981 • 23 citations

Cell cycle progression of C3H 10T½ and 3T3 cells in the absence of an increase in c-myc RNA levels

1988 • 21 citations

Carcinogen‐Mediated Amplification of Specific DNA Sequences

1982 • 20 citations

Promotion of x-ray transformation in vitro.

1982 • 18 citations

Inhibition of carcinoma formation and of vascular invasion in grafts of radiation-initiated thyroid clonogens by unirradiated thyroid cells

1988 • 15 citations

The Clonogenic Cells of the Rat Mammary and Thyroid Glands: Their Biology, Frequency of Initiation, and Promotion/Progression to Cancer

1990 • 11 citations