Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

Crystal Structure of Hck in Complex with a Src Family–Selective Tyrosine Kinase Inhibitor

1999 • 428 citations

T cell antigen receptor signal transduction

1997 • 390 citations

Structures of Src-family tyrosine kinases

1997 • 377 citations

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.

1996 • 324 citations

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

1999 • 248 citations

Modelling study of protein kinase inhibitors: Binding mode of staurosporine and origin of the selectivity of CGP 52411

1995 • 95 citations

Signal Transduction by the Lymphocyte-Specific Tyrosine Protein Kinase p56lck

1996 • 64 citations

Development of solid-phase enzyme-linked immunosorbent assays for the determination of epidermal growth factor receptor and pp60c-src tyrosine protein kinase activity

1992 • 43 citations