The role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cells

Epidermal growth factor receptor: mechanisms of activation and signalling

2003 • 1,514 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

FAK integrates growth-factor and integrin signals to promote cell migration

2000 • 1,215 citations

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

1987 • 843 citations

EGF receptor

1999 • 792 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis

1997 • 525 citations

MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF

1985 • 332 citations

Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers.

1995 • 329 citations

Epidermal Growth Factor-Induced Tumor Cell Invasion and Metastasis Initiated by Dephosphorylation and Downregulation of Focal Adhesion Kinase

2001 • 325 citations

Impaired expansion of mouse B cell progenitors lacking Btk

1995 • 314 citations

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species

2001 • 304 citations

Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade

2000 • 278 citations

Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3′-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells

1998 • 249 citations

Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines.

1984 • 231 citations

Signaling network of the Btk family kinases

2000 • 230 citations

A tyrosine kinase profile of prostate carcinoma.

1996 • 212 citations

Neuropeptide-Induced Androgen Independence in Prostate Cancer Cells: Roles of Nonreceptor Tyrosine Kinases Etk/Bmx, Src, and Focal Adhesion Kinase

2001 • 183 citations

Btk function in B cell development and response

1998 • 181 citations

Induction of Apoptosis and Fas Receptor/Fas Ligand Expression by Ischemia/Reperfusion in Cardiac Myocytes Requires Serine 727 of the STAT-1 Transcription Factor but Not Tyrosine 701

2001 • 175 citations

BTK as a Mediator of Radiation-Induced Apoptosis in DT-40 Lymphoma B Cells

1996 • 166 citations

Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines

1995 • 160 citations

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

2001 • 157 citations

Etk/Bmx as a Tumor Necrosis Factor Receptor Type 2-Specific Kinase: Role in Endothelial Cell Migration and Angiogenesis

2002 • 143 citations

A Critical Role for Phosphoinositide 3-Kinase Upstream of Gab1 and SHP2 in the Activation of Ras and Mitogen-activated Protein Kinases by Epidermal Growth Factor

2001 • 141 citations

Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation

2000 • 140 citations

Etk/Bmx Tyrosine Kinase Activates Pak1 and Regulates Tumorigenicity of Breast Cancer Cells

2001 • 131 citations

p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation

2002 • 125 citations

An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis.

1996 • 117 citations

Tec Kinase Associates with c-kit and Is Tyrosine Phosphorylated and Activated following Stem Cell Factor Binding

1994 • 100 citations

Tec kinases: modulators of lymphocyte signaling and development

2001 • 100 citations

New insights into the regulation and functions of Tec family tyrosine kinases in the immune system

2002 • 91 citations

Elevated epidermal growth factor receptor gene copy number and expression in a squamous carcinoma cell line.

1985 • 87 citations

Bmx Tyrosine Kinase Has a Redundant Function Downstream of Angiopoietin and Vascular Endothelial Growth Factor Receptors in Arterial Endothelium

2001 • 81 citations

Etk/Bmx, a PH-domain containing tyrosine kinase, protects prostate cancer cells from apoptosis induced by photodynamic therapy or thapsigargin

1999 • 80 citations

Tyrosine kinase activation in the decision between growth, differentiation, and death responses initiated from the B cell antigen receptor

2000 • 76 citations

Tec protein-tyrosine kinase is involved in interleukin-3 signaling pathway

1995 • 75 citations

Epidermal growth factor receptor status of histological sub-types of breast cancer

1988 • 72 citations

Kinase Activation of the Non-receptor Tyrosine Kinase Etk/BMX Alone Is Sufficient to Transactivate STAT-mediated Gene Expression in Salivary and Lung Epithelial Cells

1999 • 72 citations

Role of growth factors and their receptors in proliferation of microvascular endothelial cells

2002 • 68 citations

Distinct Mechanisms of Activation of Stat1 and Stat3 by Platelet-Derived Growth Factor Receptor in a Cell-Free System

1999 • 63 citations

Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation

2002 • 62 citations

The C‐terminal activation domain of the STAT‐1 transcription enhances ischemia/reperfusion‐induced apoptosis in cardiac myocytes

2002 • 54 citations

Untitled

2001 • 51 citations

Epidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling

2001 • 43 citations

The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner

2000 • 42 citations

Protein-tyrosine Phosphatase D1, a Potential Regulator and Effector for Tec Family Kinases

2000 • 42 citations

Association of EGF receptor expression with proliferating cells and of ras p21 expression with differentiating cells in various skin tumours

1990 • 39 citations

Proteolytic Activation of Etk/Bmx Tyrosine Kinase by Caspases

2001 • 36 citations

Effects of epidermal growth factor on MDA-MB-468 breast cancer cells: Alterations in polyamine biosynthesis and the expression of p21/CIP1/WAF1

1999 • 32 citations

Ligation of the α2M Signalling Receptor Elevates the Levels of p21Ras-GTP in Macrophages

1998 • 27 citations

The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals

2002 • 25 citations

Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk

2001 • 17 citations

BTK mediated apoptosis, a possible mechanism for failure to generate high titer retroviral producer clones

2000 • 16 citations

The influence of left lateral position on cardiac output changes after head up tilt measured by impedance cardiography.

1999 • 11 citations

Bruton tyrosine kinase BTK in X-linked agammaglobulinemia XLA

2000 • 9 citations