Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical “disconnection” in aging and Alzheimer’s disease

“Mini-mental state”

1975 • 82,784 citations

Statistical power analysis for the behavioral sciences

1990 • 65,781 citations

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2002 • 13,092 citations

The Jackknife, the Bootstrap and Other Resampling Plans

1982 • 7,816 citations

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

1997 • 2,394 citations

Mapping cortical change across the human life span

2003 • 2,286 citations

Regional Development of the Brain in Early Life

1968 • 2,076 citations

Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories

1997 • 1,599 citations

Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease

2003 • 923 citations

Maturation of white matter in the human brain: a review of magnetic resonance studies

2001 • 854 citations

Evidence for cortical “disconnection” as a mechanism of age-related cognitive decline

2001 • 785 citations

ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA.

1964 • 646 citations

Alzheimer's Disease Amyloid-β Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits

2001 • 643 citations

Age-Related Changes in Frontal and Temporal Lobe Volumes in Men

2001 • 630 citations

Neuron Number in the Entorhinal Cortex and CA1 in Preclinical Alzheimer Disease

2001 • 572 citations

How Can We Learn About Developmental Processes From Cross-Sectional Studies, or Can We?

2000 • 536 citations

Age-related total gray matter and white matter changes in normal adult brain. Part I: volumetric MR imaging analysis.

2002 • 526 citations

Aging and the human neocortex

2003 • 457 citations

Cytological and quantitative characteristics of four cerebral commissures in the rhesus monkey

1990 • 414 citations

Magnetic Resonance of Myelin, Myelination, and Myelin Disorders

1989 • 406 citations

White Matter Structural Integrity in Healthy Aging Adults and Patients With Alzheimer Disease

2003 • 403 citations

Two Hemispheres—One Brain: Functions of the Corpus Callosum

1987 • 380 citations

Myelinated nerve fibres in the CNS

1993 • 351 citations

Age-Induced White Matter Changes in the Human Brain: A Stereological Investigation

1997 • 330 citations

Incidence of AD may decline in the early 90s for men, later for women

2002 • 319 citations

California Verbal Learning Test--Second Edition

1987 • 286 citations

Aging and the myelinated fibers in prefrontal cortex and corpus callosum of the monkey

2001 • 275 citations

Increased Aβ Peptides and Reduced Cholesterol and Myelin Proteins Characterize White Matter Degeneration in Alzheimer's Disease

2002 • 267 citations

In Vivo Evaluation of Brain Iron in Alzheimer Disease Using Magnetic Resonance Imaging

2000 • 227 citations

Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease

1989 • 219 citations

MRI evaluation of brain iron in earlier- and later-onset Parkinson’s disease and normal subjects

1999 • 212 citations

Conduction in Segmentally Demyelinated Mammalian Central Axons

1997 • 205 citations

Effects of aging on myelinated nerve fibers in monkey primary visual cortex

2000 • 192 citations

Monoamine oxidase-B inhibitors in the treatment of Alzheimers disease

2000 • 188 citations

Pathophysiologic Mechanisms in the Development of Age-Related White Matter Changes of the Brain

1998 • 187 citations

In vivo MR evaluation of age-related increases in brain iron.

1994 • 143 citations

In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI

1994 • 136 citations

Nuclear magnetic resonance relaxation in experimental brain edema: Effects of water concentration, protein concentration, and temperature

1988 • 119 citations

Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer's disease

2002 • 112 citations

Diffusion-weighted and magnetization transfer imaging of the corpus callosum in Alzheimer’s disease

1999 • 109 citations

Diffuse Vacuolization (Spongiosis) and Arteriolosclerosis in the Frontal White Matter Occurs in Vascular Dementia

1996 • 106 citations

Cholesterol is necessary both for the toxic effect of Aβ peptides on vascular smooth muscle cells and for Aβ binding to vascular smooth muscle cell membranes

2003 • 98 citations

Magnetic Resonance Imaging White Matter Hyperintensities in Clinically Normal Elderly Individuals

1996 • 94 citations

Neurodegenerative Changes Associated with β-Amyloid Deposition in the Brains of Mice Carrying Mutant Amyloid Precursor Protein and Mutant Presenilin-1 Transgenes

2001 • 90 citations

Oligodendrocyte Precursor Cells from Different Brain Regions Express Divergent Properties Consistent with the Differing Time Courses of Myelination in These Regions

2002 • 88 citations

Increased Water Diffusion in Cerebral White Matter in Alzheimer’s Disease

1997 • 86 citations

White Matter Lesions and Dementia MRI‐Pathological Correlation

2002 • 85 citations

Gelsolin-related spinal and cerebral amyloid angiopathy

1999 • 82 citations

T2 relaxation time as a marker of brain myelination: experimental MR study in two neonatal animal models

1997 • 78 citations

CORRELATIONS BETWEEN HISTOPATHOLOGIC WHITE MATTER CHANGES AND PROTON MR RELAXATION TIMES IN DEMENTIA

1987 • 73 citations

The N -Methyl- <scp>d</scp> -Aspartate Antagonist CNS 1102 Protects Cerebral Gray and White Matter From Ischemic Injury Following Temporary Focal Ischemia in Rats

2000 • 70 citations

Senile plaques do not progressively accumulate with normal aging

1994 • 68 citations

Changes in lipid phase behaviour in human myelin during maturation and aging

1983 • 63 citations

MR assessment of the brain maturation during the perinatal period: quantitative T2 MR study in premature newborns

1999 • 60 citations

Quantitative magnetic resonance imaging and the severity of dementia in Alzheimer's disease

1988 • 53 citations

Benton visual retention test : manual

1992 • 51 citations

The effects of aging on the frequency of nerve fibers in rhesus monkey striate cortex

2000 • 51 citations

Pathologic findings of silent hyperintense white matter lesions on MRI

1999 • 49 citations

Multimodal Imaging in Alzheimer's Disease

1990 • 47 citations

Basics of Magnetic Resonance Imaging

1988 • 47 citations

Benton Visual Retention Test -- Fifth Edition

1991 • 44 citations

Evaluation of myelination by means of the T2 value on magnetic resonance imaging

1993 • 40 citations

Ultrastructural analyses of β-amyloid in the aged dog brain: Neuronal β-amyloid is localized to the plasma membrane

2000 • 37 citations

Selegiline treatment and the extent of degenerative changes in brain tissue of patients with Alzheimer's disease

2000 • 28 citations

Biexponential T2 Relaxation Time Analysis of the Brain

2002 • 25 citations

Assessment of Brain Maturation by T2-Weighted MRI*, **

1992 • 25 citations

Sequential changes in MR water proton relaxation time detect the process of rat brain myelination during maturation

2001 • 22 citations

Magnetic resonance imaging in vivo monitoring of T2 relaxation time: Quantitative assessment of primate brain maturation

1995 • 16 citations

Demonstration and distribution of tau‐positive glial coiled body‐like structures in white matter and white matter threads in early onset Alzheimer’s disease

2002 • 14 citations

Pattern Recognition in Magnetic Resonance Imaging of Myelin Disorders

1989 • 6 citations

Deleted Work

1955 • 0 citations