Dysregulated Ryanodine Receptors Mediate Cellular Toxicity

The versatility and universality of calcium signalling

2000 • 5,407 citations

Current Protocols in Molecular Biology

2001 • 2,451 citations

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca ²⁺ Responses

1998 • 2,130 citations

PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor)

2000 • 1,940 citations

Regulation of Phosphoinositide-Specific Phospholipase C

2001 • 1,604 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase Pathway

2001 • 908 citations

Statistical Methods in Medical Research

1972 • 754 citations

Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

2001 • 594 citations

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

2001 • 578 citations

Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12

1998 • 422 citations

Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium

1992 • 363 citations

Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate-evoked local cytosolic Ca2+ signals

1999 • 362 citations

Soluble Fas Ligand Induces Epithelial Cell Apoptosis in Humans with Acute Lung Injury (ARDS)

1999 • 358 citations

Introduction of macromolecules into cultured mammalian cells by osmotic lysis of pinocytic vesicles

1982 • 320 citations

Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons

2000 • 310 citations

Phosphorylation-Dependent Regulation of Ryanodine Receptors

2001 • 285 citations

Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy

2002 • 279 citations

Necrotic Cell Death in C. elegans Requires the Function of Calreticulin and Regulators of Ca2+ Release from the Endoplasmic Reticulum

2001 • 277 citations

Protein Kinase A Phosphorylation of the Ryanodine Receptor Does Not Affect Calcium Sparks in Mouse Ventricular Myocytes

2002 • 261 citations

FKBP12.6-Mediated Stabilization of Calcium-Release Channel (Ryanodine Receptor) as a Novel Therapeutic Strategy Against Heart Failure

2003 • 261 citations

T Cells Deficient in Inositol 1,4,5-Trisphosphate Receptor Are Resistant to Apoptosis

1997 • 259 citations

Selective Binding of FKBP12.6 by the Cardiac Ryanodine Receptor

1996 • 249 citations

Cardiac Intracellular Calcium Release Channels

2000 • 222 citations

Altered Stoichiometry of FKBP12.6 Versus Ryanodine Receptor as a Cause of Abnormal Ca ²⁺ Leak Through Ryanodine Receptor in Heart Failure

2000 • 221 citations

Heterotetrameric Complex Formation of Inositol 1,4,5-Trisphosphate Receptor Subunits

1995 • 214 citations

Bcl-2-dependent modulation of Ca2+ homeostasis and store-operated channels in prostate cancer cells

2002 • 213 citations

Measurement of Resting Cytosolic Ca2+ Concentrations and Ca2+ Store Size in HEK-293 Cells Transfected with Malignant Hyperthermia or Central Core Disease Mutant Ca2+ Release Channels

1999 • 212 citations

Protein–protein interactions in intracellular Ca2+-release channel function

1999 • 197 citations

Effects of Rapamycin on Ryanodine Receptor/Ca ²⁺ -Release Channels From Cardiac Muscle

1996 • 177 citations

Control of apoptosis by IP3and ryanodine receptor driven calcium signals

2000 • 151 citations

The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis

1996 • 149 citations

Regulation of Cardiac Muscle Ca2+ Release Channel by Sarcoplasmic Reticulum Lumenal Ca2+

1998 • 149 citations

Chlorocresol: an activator of ryanodine receptor-mediated Ca2+ release.

1993 • 136 citations

Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity

2001 • 133 citations

Ca2+-sensor region of IP3 receptor controls intracellular Ca2+ signaling

2001 • 131 citations

Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides

2001 • 116 citations

FKBP Binding Characteristics of Cardiac Microsomes from Diverse Vertebrates

2001 • 111 citations

Depletion of Intracellular Ca2+ by Caffeine and Ryanodine Induces Apoptosis of Chinese Hamster Ovary Cells Transfected with Ryanodine Receptor

2000 • 100 citations

Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death

2000 • 98 citations

Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure

1999 • 96 citations

Intracellular Calcium and Cell Death during Ischemia in Neonatal Rat White Matter AstrocytesIn Situ

1998 • 88 citations

Human disease: Calcium signaling in polycystic kidney disease

2001 • 86 citations

Sparks and Puffs in Oligodendrocyte Progenitors: Cross Talk between Ryanodine Receptors and Inositol Trisphosphate Receptors

2001 • 86 citations

Depletion of intracellular calcium stores is toxic to SH-SY5Y neuronal cells

2002 • 74 citations

SR compartment calcium and cell apoptosis in SERCA overexpression

1999 • 67 citations

Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release channels in mammalian tissues and cell lines

1997 • 64 citations

Regulation of Ryanodine Receptor Opening by Lumenal Ca2+ Underlies Quantal Ca2+ Release in PC12 Cells

1999 • 56 citations

FKBP12 associates tightly with the skeletal muscle type 1 ryanodine receptor, but not with other intracellular calcium release channels

2001 • 53 citations

Expression and Functional Characterization of the Cardiac Muscle Ryanodine Receptor Ca2+ Release Channel in Chinese Hamster Ovary Cells

1999 • 45 citations

Cellular Distribution of Ca ²⁺ Pumps and Ca ²⁺ Release Channels in Rat Cardiac Hypertrophy Induced by Aortic Stenosis

1998 • 43 citations

In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6

2003 • 40 citations

Carbachol triggers RyR‐dependent Ca²⁺ release via activation of IP₃ receptors in isolated rat gastric myocytes

2002 • 38 citations

Serum-activated assembly and membrane translocation of an endogenous Rac1:effector complex

2001 • 28 citations

Fluorescent Methods for Measuring and Imaging Cytosolic Free Ca2+in Neutrophils

1996 • 23 citations

Effects of BAPTA-AM, Forskolin, DSF and Z.VAD.fmk on PDT-induced apoptosis and m-THPC phototoxicity on B16 cells.

2002 • 19 citations

Analysis of Type 1 Ryanodine Receptor-12 kDa FK506-Binding Protein Interaction

2001 • 13 citations