Phorbol ester-mediated desensitization of histamine H1 receptors on a cultured smooth muscle cell line

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model

1985 • 732 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.

1982 • 573 citations

1-(5-isoquinol inesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase c in rabbit platelets

1984 • 437 citations

Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry.

1986 • 369 citations

Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.

1987 • 206 citations

Specific binding of 3H-mepyramine to histamine H1 receptors in intestinal smooth muscle

1977 • 141 citations

Different mechanisms of desensitization of adenylate cyclase by isoproterenol and prostaglandin E1 in human fibroblasts. Role of regulatory components in desensitization.

1982 • 115 citations

Histamine H₁‐Receptor Binding Sites in Guinea Pig Brain Membranes: Regulation of Agonist Interactions by Guanine Nucleotides and Cations

1980 • 91 citations

Androgen receptors in a Syrian hamster ductus deferens tumour cell line

1974 • 89 citations

Identification of serine 24 as the unique site on the transferrin receptor phosphorylated by protein kinase C.

1986 • 75 citations

Histamine‐induced inositol phospholipid breakdown in the longitudinal smooth muscle of guinea‐pig ileum

1985 • 61 citations

Anomalous equilibrium binding properties of high-affinity racemic radioligands.

1981 • 55 citations

The mitogenic effects of vasoactive neuropeptides on cultured smooth muscle cell lines

1987 • 51 citations

Histamine activates H1-receptors to induce cytosolic free calcium transients in cultured vascular smooth muscle cells from rat aorta

1986 • 49 citations

Desensitization of histamine H1 receptor-mediated cyclic GMP formation in mouse neuroblastoma cells.

1979 • 41 citations

Phorbol ester or diacylglycerol modulates somatostatin binding to its receptors on rat pancreatic acinar cell membranes.

1986 • 41 citations

Specific desensitization of histamine H1 receptor-mediated [3H]glycogen hydrolysis in brain slices.

1981 • 33 citations

Characterization of functional histamine H1 receptors on a cultured smooth muscle cell line

1988 • 29 citations

Effects of agonist and phorbol ester on adrenergic receptors of DDT1 MF-2 cells.

1987 • 23 citations

Tachyphylaxis of guinea-pig ileum to histamine and furtrethonium.

1973 • 21 citations