PHD Domain-Mediated E3 Ligase Activity Directs Intramolecular Sumoylation of an Adjacent Bromodomain Required for Gene Silencing

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

2002 • 1,207 citations

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

2006 • 1,129 citations

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

2006 • 916 citations

Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF

2006 • 777 citations

Reading protein modifications with interaction domains

2006 • 657 citations

KAP-1, a novel corepressor for the highly conserved KRAB repression domain.

1996 • 637 citations

Specification of SUMO1- and SUMO2-interacting Motifs

2006 • 559 citations

Modification in reverse: the SUMO proteases

2007 • 549 citations

The Small Ubiquitin-like Modifier-1 (SUMO-1) Consensus Sequence Mediates Ubc9 Binding and Is Essential for SUMO-1 Modification

2001 • 506 citations

Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD

2001 • 504 citations

Something about SUMO inhibits transcription

2005 • 491 citations

p300 Transcriptional Repression Is Mediated by SUMO Modification

2003 • 447 citations

PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases

2002 • 420 citations

Role of SUMO-Interacting Motif in Daxx SUMO Modification, Subnuclear Localization, and Repression of Sumoylated Transcription Factors

2006 • 413 citations

Structure and acetyl-lysine recognition of the bromodomain

2007 • 411 citations

KAP-1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins: a Potential Role for Krüppel-Associated Box–Zinc Finger Proteins in Heterochromatin-Mediated Gene Silencing

1999 • 373 citations

SUMO Promotes HDAC-Mediated Transcriptional Repression

2004 • 339 citations

A comprehensive catalog of human KRAB-associated zinc finger genes: Insights into the evolutionary history of a large family of transcriptional repressors

2006 • 331 citations

The KAP1 Corepressor Functions To Coordinate the Assembly of De Novo HP1-Demarcated Microenvironments of Heterochromatin Required for KRAB Zinc Finger Protein-Mediated Transcriptional Repression

2006 • 299 citations

Small Ubiquitin-like Modifier (SUMO) Recognition of a SUMO Binding Motif

2005 • 254 citations

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation

2005 • 246 citations

The SUMO Isopeptidase Ulp2 Prevents Accumulation of SUMO Chains in Yeast

2003 • 239 citations

Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains

2001 • 197 citations

Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions

2000 • 196 citations

A Mechanism for Inhibiting the SUMO Pathway

2004 • 179 citations

The PHD Finger/Bromodomain of NoRC Interacts with Acetylated Histone H4K16 and Is Sufficient for rDNA Silencing

2005 • 135 citations

Nucleosome Binding by the Bromodomain and PHD Finger of the Transcriptional Cofactor p300

2004 • 125 citations

NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression

2006 • 106 citations

Overproduction of eukaryotic SUMO-1- and SUMO-2-conjugated proteins in Escherichia coli

2004 • 105 citations

SUMO Modification of Human XRCC4 Regulates Its Localization and Function in DNA Double-Strand Break Repair

2006 • 100 citations

Involvement of SUMO Modification in MBD1- and MCAF1-mediated Heterochromatin Formation

2006 • 88 citations

Overproduction of eukaryotic SUMO-1- and SUMO-2-conjugated proteins in Escherichia coli

2004 • 87 citations

A Small Conserved Surface in SUMO Is the Critical Structural Determinant of Its Transcriptional Inhibitory Properties

2005 • 79 citations

SUMO-1 Modification of PIASy, an E3 Ligase, Is Necessary for PIASy-Dependent Activation of Tcf-4

2005 • 61 citations

Sumoylation of the Transcriptional Intermediary Factor 1β (TIF1β), the Co-repressor of the KRAB Multifinger Proteins, Is Required for Its Transcriptional Activity and Is Modulated by the KRAB Domain

2007 • 60 citations

Immunoprecipitation techniques for the analysis of transcription factor complexes

2002 • 55 citations

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