Functional and phenotypic analysis of tumor-infiltrating. Lymphocytes isolated from human primary and metastatic. Liver tumors and cultured in recombinant interleukin-2

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating Lymphocytes

1986 • 1,787 citations

Constant-Infusion Recombinant Interleukin-2 in Adoptive Immunotherapy of Advanced Cancer

1987 • 1,224 citations

Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. IX. The quantitation of natural killer cell activity

1981 • 703 citations

Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis.

1986 • 698 citations

Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

1987 • 497 citations

Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma.

1987 • 478 citations

Lymphokine-activated killer cells. Analysis of progenitors and effectors.

1986 • 403 citations

Glioblastoma cells release interleukin 1 and factors inhibiting interleukin 2-mediated effects.

1984 • 367 citations

Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes.

1986 • 319 citations

Interleukin 2 expanded tumor-infiltrating lymphocytes in human renal cell cancer: isolation, characterization, and antitumor activity.

1988 • 302 citations

Interleukin 2 activation of cytotoxic T-lymphocytes infiltrating into human metastatic melanomas.

1986 • 259 citations

Adoptive immunotherapy of murine hepatic metastases with lymphokine activated killer (LAK) cells and recombinant interleukin 2 (RIL 2) can mediate the regression of both immunogenic and nonimmunogenic sarcomas and an adenocarcinoma.

1985 • 212 citations

Prognostic significance of the histological features of malignant melanoma

1979 • 175 citations

Augmentation of organ-associated natural killer activity by biological response modifiers. Isolation and characterization of large granular lymphocytes from the liver.

1984 • 167 citations

Tumor-derived interleukin-2-dependent lymphocytes in adoptive immunotherapy of lung cancer

1987 • 140 citations

Depression of natural killer cytotoxic activity in lymphocytes infiltrating human pulmonary tumors.

1985 • 129 citations

Long-term interleukin 2-dependent growth and cytotoxic activity of tumor-infiltrating lymphocytes from human squamous cell carcinomas of the head and neck.

1987 • 129 citations

A new approach to generating antitumor effectors for adoptive immunotherapy using human adherent lymphokine-activated killer cells.

1988 • 120 citations

In situ analysis of the mononuclear cell infiltrate in primary malignant melanoma of the skin.

1983 • 93 citations

Characterization of cells from invaded lymph nodes in patients with solid tumors. Lymphokine requirement for tumor-specific lymphoproliferative response.

1987 • 91 citations

Quantitation of proliferative and cytotoxic precursor cells directed against human tumours: Limiting dilution analysis in peripheral blood and at the tumour site

1982 • 90 citations

Separation of tumor-infiltrating lymphocytes from tumor cells in human solid tumors

1986 • 80 citations

Quantitation and clonal isolation of cytolytic T lymphocyte precursors selectively infiltrating murine sarcoma virus-induced tumors.

1981 • 72 citations

Immunology of Tumor Infiltrating Lymphocytes

1985 • 70 citations

Natural killer‐interferon system in patients with preleukaemic states

1984 • 39 citations

Antigenic, functional, and molecular genetic studies of human natural killer cells and cytotoxic T lymphocytes not restricted by the major histocompatibility complex.

1986 • 34 citations

Spontaneous production of a suppressor factor by a human macrophage-like cell line U937. II. Suppression of antigen- and mitogen-induced blastogenesis, IL 2 production and IL 2 receptor expression in T lymphocytes.

1987 • 29 citations

Double immunoenzyme staining method for analysis of tissue and blood lymphocyte subsets with monoclonal antibodies.

1987 • 29 citations

Supernatant derived from a human hepatocellular carcinoma cell line (PLC/PRF/5) depresses natural killer (NK) cell activity

1983 • 18 citations

Characterization of novel anti-tumor effector cells in long-term cultures of human tumor-infiltrating lymphocytes.

1988 • 16 citations