Interleukin-4-mediated Protection of Primary B Cells from Apoptosis through Stat6-dependent Up-regulation of Bcl-xL

Stat3 as an Oncogene

1999 • 2,770 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis

1999 • 721 citations

Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice

1999 • 710 citations

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

1999 • 642 citations

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesisin vivo

2000 • 594 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells

1995 • 426 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

THE CENTRAL EFFECTORS OF CELL DEATH IN THE IMMUNE SYSTEM

1999 • 390 citations

The biology of Stat4 and Stat6

2000 • 310 citations

Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4

1997 • 293 citations

Erythropoietin Can Induce the Expression of Bcl-xLthrough Stat5 in Erythropoietin-dependent Progenitor Cell Lines

1999 • 280 citations

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1995 • 258 citations

Components of a stat recognition code: Evidence for two layers of molecular selectivity

1995 • 254 citations

Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL-4.

1993 • 214 citations

Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40.

1994 • 210 citations

Antiapoptotic activity ofStat5required during terminal stages of myeloid differentiation

2000 • 188 citations

Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene.

1997 • 188 citations

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal.

1995 • 167 citations

Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

1996 • 158 citations

IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway.

1996 • 148 citations

Stat Proteins Control Lymphocyte Proliferation by Regulating p27^Kip1 Expression

1998 • 133 citations

Spontaneous and glucocorticoid-induced apoptosis in human mature T lymphocytes

1995 • 128 citations

Cyclosporin-a sensitive induction of NF-AT in murine B cells

1994 • 124 citations

IL-4 induces Fas resistance in B cells.

1996 • 115 citations

A Novel Gene Coding for a Fas Apoptosis Inhibitory Molecule (FAIM) Isolated from Inducibly Fas-resistant B Lymphocytes

1999 • 115 citations

Interleukin-4-induced STAT6 Recognizes and Activates a Target Site in the Promoter of the Interleukin-4 Receptor Gene

1996 • 110 citations

Selective regulation ofBcl-X_Lby a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies

1998 • 110 citations

The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.

1991 • 105 citations

Inducible nuclear expression of NF-kappa B in primary B cells stimulated through the surface Ig receptor.

1991 • 103 citations

Activation-Induced Inhibition of Interleukin 6–Mediated T Cell Survival and Signal Transducer and Activator of Transcription 1 Signaling

2000 • 99 citations

Stat6 and IRS-2 Cooperate in Interleukin 4 (IL-4)-Induced Proliferation and Differentiation but Are Dispensable for IL-4-Dependent Rescue from Apoptosis

2002 • 87 citations

Bcl-x protects primary B cells against Fas-mediated apoptosis.

1997 • 81 citations

Interleukin-15 Prevents Mouse Mast Cell Apoptosis through STAT6-mediated Bcl-xL Expression

2001 • 80 citations

Regulation of apoptosis by tyrosine-containing domains of IL-4R alpha: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis.

1998 • 59 citations

Antigen-receptor engagement in B cells induces nuclear expression of STAT5 and STAT6 proteins that bind and transactivate an IFN-gamma activation site.

1996 • 48 citations

STATs as Mediators of Cytokine-Induced Responses

1998 • 42 citations

Regulation of Apoptosis by Tyrosine-Containing Domains of IL-4Rα: Y497 and Y713, But Not the STAT6-Docking Tyrosines, Signal Protection from Apoptosis

1998 • 38 citations

Cutting Edge: A Novel Mechanism for Rescue of B Cells from CD95/Fas-Mediated Apoptosis

1999 • 36 citations

Signals and susceptibility to programmed death in B cells

1996 • 35 citations

Regulation of Antibody Class Switching to IgE: Characterization of an IL‐4‐Responsive Region in the Immunoglobulin Heavy‐Chain Germline ε Promoter^a

1995 • 27 citations

Regulation of bcl-xl expression and Fas susceptibility in mouse B cells by CD40 ligation, surface IgM crosslinking and IL-4

1996 • 24 citations