Enantioselective pharmacokinetics of dl-threo-methylphenidate in humans.

A comparison of the capacities of isomers of amphetamine, deoxypipradrol and methylphenidate to inhibit the uptake of tritiated catecholamines into rat cerebral cortex slices, synaptosomal preparations of rat cerebral cortex, hypothalamus and striatum and into adrenergic nerves of rabbit aorta.

1972 • 296 citations

Importance of Drug Enantiomers in Clinical Pharmacology

1985 • 278 citations

Pharmacokinetics of methylphenidate in man, rat and monkey.

1983 • 217 citations

Pharmacology of the enantiomers of threo-methylphenidate.

1987 • 192 citations

Stereochemistry and biological activity of drugs

1983 • 178 citations

Metabolism and disposition of methylphenidate-14C: studies in man and animals.

1974 • 155 citations

SHORT TERM EFFECTS OF METHYLPHENIDATE ON THE COGNITIVE, LEARNING AND ACADEMIC PERFORMANCE OF CHILDREN WITH ATTENTION DEFICIT DISORDER IN THE LABORATORY AND THE CLASSROOM*^,†

1986 • 154 citations

Methylphenidate Hydrochloride Given With or Before Breakfast: II. Effects on Plasma Concentration of Methylphenidate and Ritalinic Acid

1983 • 115 citations

Psychopharmacology of Attention Deficit Disorder: Pharmacokinetic, Neuroendocrine, and Behavioral Measures Following Acute and Chronic Treatment with Methylphenidate

1982 • 104 citations

Sustained Release Methylphenidate: Pharmacokinetic Studies in ADDH Males

1989 • 98 citations

Pharmacokinetics of methylphenidate in hyperkinetic children.

1979 • 78 citations

Comparison of the effects of the isomers of amphetamine, methylphenidate and deoxypipradrol on the uptake of l-[3H]norepinephrine and [3H]dopamine by synaptic vesicles from rat whole brain, striatum and hypothalamus.

1979 • 71 citations

Stereoselective disposition of methylphenidate in children with attention-deficit disorder.

1987 • 68 citations

Effects of Methylphenidate Dosage in Hyperactive Reading-disabled Children: I. Behavior and Cognitive Performance Effects

1988 • 63 citations

Development of enantioselective gas chromatographic quantitation assay for dl-threo-methylphenidate in biological fluids

1986 • 58 citations

Enantioselective Aspects of the Disposition of dl-threo-Methylphenidate after the Administration of a Sustained-Release Formulation to Children with Attention Deficit-Hyperactivity Disorder

1989 • 53 citations

Methylphenidate oral dose plasma concentrations and behavioral response in children

1982 • 51 citations

Conformational similarities between molecular models of phenethylamine and of potent inhibitors of the uptake of tritiated norepinephrine by adrenergic nerves in rabbit aorta.

1970 • 51 citations

Distribution of methylphenidate and p-hydroxymethylphenidate in rats.

1984 • 50 citations

Kinetic Analysis of Enantiomers of Threo-Methylphenidate and Its Metabolite in Two Healthy Subjects after Oral Administration as Determined by a Gas Chromatographic-Mass Spectrometric Method

1990 • 50 citations

Problems in Therapeutic Drug Monitoring

1988 • 47 citations

The pharmacological and toxicological significance of the stereochemistry of drug disposition.

1988 • 44 citations

Components of Attention, Methylphenidate Dosage, and Blood Levels in Children With Attention Deficit Disorder

1986 • 43 citations

Attention Deficit Disorder With Hyperactivity: Differential Effects of Methylphenidate on Impulsivity

1985 • 41 citations

The absorption of sustained‐release methylphenidate formulations compared to an immediate‐release formulation

1989 • 40 citations

Pharmacokinetics of Methylphenidate in the Rat Using Single-Ion Monitoring GLC-Mass Spectrometry

1977 • 35 citations

Comparison of sustained-release and standard methylphenidate in the treatment of minimal brain dysfunction.

1980 • 34 citations

Metabolism of methylphenidate in dog and rat.

1981 • 31 citations

Chiral pharmacology and its consequences for therapeutic monitoring

1986 • 29 citations

Slow-release methylphenidate: problems when children chew tablets.

1984 • 27 citations

Enantioselective gas chromatographic assay with electron-capture detection for dl-ritalinic acid in plasma

1990 • 26 citations

Stereoselective Urinary Pharmacokinetics of dl-threo-Methylphenidate and Its Major Metabolite in Humans

1992 • 25 citations

Gas chromatographic—mass spectrometric analysis of threo-methylphenidate enantiomers in plasma

1989 • 12 citations

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