Spontaneous Reactivation of Thymidine Kinase-Deficient, Acyclovir-Resistant Type 2 Herpes Simplex Virus: Masked Heterogeneity or Reversion?

Severe Acquired Immunodeficiency in Male Homosexuals, Manifested by Chronic Perianal Ulcerative Herpes Simplex Lesions

1981 • 1,242 citations

Sero-epidemiological and -sociological patterns of herpes simplex virus infection in the world.

1990 • 530 citations

Acyclovir-Resistant Herpes Simplex Virus Infections in Patients with the Acquired Immunodeficiency Syndrome

1989 • 470 citations

A Seroepidemiologic Survey of the Prevalence of Herpes Simplex Virus Type 2 Infection in the United States

1989 • 463 citations

A Controlled Trial Comparing Foscarnet with Vidarabine for Acyclovir-Resistant Mucocutaneous Herpes Simplex in the Acquired Immunodeficiency Syndrome

1991 • 364 citations

Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.

1989 • 360 citations

Herpes Simplex Virus Resistant to Acyclovir

1990 • 357 citations

Acyclovir

1989 • 351 citations

Resistance to Antiviral Drugs of Herpes Simplex Virus Isolated from a Patient Treated with Acyclovir

1982 • 345 citations

The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice

1978 • 337 citations

Oral Acyclovir for Prevention of Herpes Simplex Virus Reactivation After Marrow Transplantation

1984 • 261 citations

Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo

1980 • 245 citations

ISOLATION AND CHARACTERISATION OF RESISTANT HERPES SIMPLEX VIRUS AFTER ACYCLOVIR THERAPY

1982 • 239 citations

The Role of Herpes Simplex Virus Type 1 Thymidine Kinase in Pathogenesis

1989 • 226 citations

Herpes simplex virus variants restraint to high concentrations of acyclovir exist in clinical isolates

1982 • 191 citations

Frequency and Significance of Acyclovir-Resistant Herpes Simplex Virus Isolated from Marrow Transplant Patients Receiving Multiple Courses of Treatment with Acyclovir

1983 • 184 citations

Progressive Esophagitis from Acyclovir-Resistant Herpes Simplex

1989 • 183 citations

Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion

1979 • 159 citations

Recurrent Acyclovir-Resistant Genital Herpes in an Immunocompetent Patient

1993 • 157 citations

Evidence that the 'Active Centre' of the Herpes Simplex Virus Thymidine Kinase Involves an Interaction between Three Distinct Regions of the Polypeptide

1986 • 149 citations

Epidemiology of Genital Herpes in Pittsburgh: Serologic, Sexual, and Racial Correlates of Apparent and Inapparent Herpes Simplex Infections

1990 • 147 citations

Infections Caused by Herpes Simplex Virus in the Immunocompromised Host: Natural History And Topical Acyclovir Therapy

1984 • 132 citations

Oral Acyclovir Therapy for Mucocutaneous Herpes Simplex Virus Infections in Immunocompromised Marrow Transplant Recipients

1985 • 129 citations

In vitro and in vivo characterization of herpes simplex virus clinical isolates recovered from patients infected with human immunodeficiency virus

1991 • 127 citations

Latency-associated transcript but not reactivatable virus is present in sensory ganglion neurons after inoculation of thymidine kinase-negative mutants of herpes simplex virus type 1

1989 • 87 citations

Herpes simplex virus thymidine kinase expression in trigeminal ganglion infection: Correlation of enzyme activity with ganglion virus titer and evidence of in vivo complementation

1981 • 81 citations

In Vitro Sensitivity to Acyclovir in Genital Herpes Simplex Viruses from Acyclovir-Treated Patients

1983 • 78 citations

Analysis of the thymidine kinase gene from clinically isolated acyclovir-resistant herpes simplex viruses

1991 • 70 citations

Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates

1985 • 66 citations

Genetic Interactions Between Temperature-sensitive Mutants of Types 1 and 2 Herpes Simplex Viruses

1973 • 57 citations

Viral resistance, clinical experience.

1985 • 52 citations

Intranasal Challenge of Mice with Herpes Simplex Vims: An Experimental Model for Evaluation of the Efficacy of Antiviral Drugs

1976 • 50 citations

Sensitivity of herpes virus isolates from acyclovir clinical trials

1982 • 47 citations

Characterisation of acyclovir-resistant and -sensitive clinical herpes simplex virus isolates from an immunocompromised patient

1987 • 32 citations

Chronic Suppression for Six Months Compared With Intermittent Lesional Therapy of Recurrent Genital Herpes Using Oral Acyclovir

1988 • 23 citations

Systemic Antivirals in Herpesvirus Infections

1993 • 21 citations

Interallelic complementation of mutants of herpes simplex virus deficient in deoxypyrimidine kinase activity

1978 • 15 citations

Treatment of Herpes Genitalis

1988 • 7 citations