Cloned mouse lymphocytes permit analysis of somatic mutations that occur in vivo

T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views.

1980 • 574 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

T cell antigen receptors and the immunoglobulin supergene family

1985 • 453 citations

Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene.

1984 • 435 citations

Development and Function of Subpopulations of Thymocytes and T Lymphocytes

2015 • 296 citations

Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells

1983 • 293 citations

Effect of gamma rays at the dihydrofolate reductase locus: Deletions and inversions

1986 • 233 citations

Isolation of transforming DNA: Cloning the hamster aprt gene

1980 • 226 citations

The nature of mutants induced by ionising radiation in cultured hamster cells III. Molecular characterization of HPRT-deficient mutants induced by γ-rays or α-particles showing that the majority have deletions of all or part of the hprt gene

1986 • 207 citations

Molecular evidence for new mutation at the hprt locus in Lesch-Nyhan patients

1984 • 198 citations

A physical map of 4 million bp around the Duchenne muscular dystrophy gene on the human X-chromosome

1986 • 152 citations

Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations

1986 • 150 citations

Deletion and amplification of the HGPRT locus in Chinese hamster cells.

1983 • 147 citations

In vivo somatic mutations in human lymphocytes frequently result from major gene alterations

1985 • 146 citations

Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistant T lymphocytes

1985 • 143 citations

Mutation frequency in human lymphocytes increases with age

1984 • 138 citations

Cloned cDNA sequences of the hypoxanthine/guanine phosphoribosyltransferase gene from a mouse neuroblastoma cell line found to have amplified genomic sequences.

1982 • 136 citations

Methylation of the mouse hprt gene differs on the active and inactive X chromosomes.

1986 • 105 citations

Measurement of spontaneous and X-irradiation-induced 6-thioguanine-resistant human blood lymphocytes using a T-cell cloning technique

1984 • 102 citations

Interleukin-2 Dependent Culture of Cytolytic T Cell Lines

1981 • 102 citations

Mutations induced by X-rays at the HPRT locus in cultured Chinese hamster cells are mostly large deletions

1985 • 100 citations

A method to quantify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes

1985 • 97 citations

Structure of mutant alleles at the aprt locus of Chinese hamster ovary cells

1983 • 94 citations

MOLECULAR GENETIC ANALYSIS OF THE DILUTE-SHORT EAR (d-se) REGION OF THE MOUSE

1986 • 89 citations

Structure of the dihydrofolate reductase gene in Chinese hamster ovary cells

1983 • 87 citations

Mosaicism of peripheral blood lymphocyte populations in females heterozygous for the Lesch-Nyhan mutation

1974 • 85 citations

Mutant chinese hamster cells with a thermosensitive hypoxanthine-guanine phosphoribosyltransferase

1975 • 83 citations

Use of T-cell receptor gene probes to quantify the in vivo hprt mutations in human T-lymphocytes

1986 • 77 citations

SOUTHERN ANALYSIS OF GENOMIC ALTERATIONS IN GAMMA-RAY-INDUCED APRT- HAMSTER CELL MUTANTS

1986 • 77 citations

The thalassemias: molecular mechanisms of human genetic disease.

1983 • 61 citations

A single micromanipulated stem cell gives rise to multiple T-cell receptor gene rearrangements in the thymus in vitro

1986 • 57 citations

High-frequency structural gene deletion as the basis for functional hemizygosity of the adenine phosphoribosyltransferase locus in Chinese hamster ovary cells.

1983 • 56 citations

Limit-dilution assay and clonal expansion of all T cells capable of proliferation

1982 • 53 citations

GENETIC ANALYSIS OF A MOUSE t COMPLEX LOCUS THAT IS HOMOLOGOUS TO A KIDNEY cDNA CLONE

1986 • 53 citations

Trans regulation of the phosphoenolpyruvate carboxykinase (GTP) gene, identified by deletions in chromosome 7 of the mouse.

1986 • 52 citations

Factors that affect the frequency of thioguanine‐resistant lymphocytes in mice following exposure to ethylnitrosourea

1987 • 50 citations

Molecular Analysis of X-ray-induced Mutants at the HPRT Locus in V79 Chinese Hamster Cells

1986 • 49 citations

Mutagenicity testing in mammalian cells

1980 • 48 citations

Molecular basis of X-ray-induced mutation at the HPRT locus in human lumphocytes

1986 • 47 citations

Alterations of Gene Structure in Ethyl Methane Sulfonate-Induced Mutants of Mammalian Cells

1982 • 41 citations

On the nature of the mutations induced by the diolepoxide of benzo[a]pyrene in mammalian cells

1984 • 34 citations

The nature of mutants by ionising radiation in cultured hamster cells

1984 • 31 citations

Characterization of mutations induced by 2-(N-acetoxy-N-acetyl)aminofluorene in the dihydrofolate reductase gene of cultured hamster cells.

1986 • 27 citations

Frequency of 6-thioguanine-resistant T cells is inversely related to the declining T-cell activities in aging mice.

1986 • 26 citations

A study of the frequency of sister-chromatid exchange and of thioguanine-resistant cells in mouse spleen lymphocytes after in vivo exposure to ethylnitrosourea

1985 • 23 citations

Two populations of heterozygote erythrocytes in moderate hypoxanthine guanine phosphoribosyltransferase deficiency

1976 • 13 citations

Cited By (0)

Loading...