Developmental gene expression in cancer

SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEM

1965 • 1,851 citations

1,4-Diaminobutane (Putrescine), Spermidine, and Spermine

1976 • 1,203 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

Alpha-Fetoprotein in Ontogenesis and its Association with Malignant Tumors

1971 • 892 citations

Evolution of a Gene

1975 • 554 citations

Synthesis of -fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus.

1972 • 473 citations

Crystallization, Characterization and Metabolic Regulation of Two Types of Pyruvate Kinase Isolated from Rat Tissues*

1967 • 456 citations

Model for the regulation of mRNA translation applied to haemoglobin synthesis

1974 • 416 citations

Perspectives on alkaline phosphatase isoenzymes

1974 • 402 citations

The Second Sir Hans Krebs Lecture

2005 • 397 citations

Multimolecular Forms of Pyruvate Kinase from Rat and Other Mammalian Tissues*

1972 • 359 citations

LACTIC DEHYDROGENASE IN HUMAN NEOPLASTIC TISSUES.

1964 • 351 citations

Eukaryotic DNA Polymerases

1977 • 315 citations

Regulation of Amino Acid Decarboxylation

1974 • 297 citations

Foetal “Antigens” in Cancer

1972 • 268 citations

Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis.

1978 • 195 citations

Cancer, Differentiation and Embryonic Antigens: Some Central Problems

1974 • 183 citations

Enzyme patterns in fetal, adult and neoplastic rat tissues

1976 • 180 citations

Genetic and Developmental Control of Multiple Forms of l-Glycerol 3-Phosphate Dehydrogenase

1974 • 179 citations

Enolase isoenzymes

1976 • 179 citations

Variation of Deoxyribonucleic Acid Polymerase Activities during Rat Liver Regeneration

1972 • 177 citations

Properties of Thymidine Kinase Partially Purified from Human Fetal and Adult Tissue

1972 • 171 citations

Characterization of the Messenger Ribonucleoprotein Released from Reticulocyte Polyribosomes by EDTA Treatment

1971 • 157 citations

The Crabtree effect: a review.

1961 • 146 citations

Protein tightly bound to globin mRNA

1972 • 142 citations

Interrelationships and functions of the pyruvate kinase isozymes and their variant forms: a review.

1977 • 142 citations

Control of globin synthesis by hemin: Factors influencing formation of an inhibitor of globin chain initiation in reticulocyte lysates

1972 • 141 citations

Glycolytic and gluconeogenic enzyme activities in parenchymal and non-parenchymal cells from mouse liver

1972 • 137 citations

REVIEW THE BIOSYNTHESIS OF HORMONES BY NON-ENDOCRINE TUMOURS-A REVIEW

1975 • 133 citations

New Aspects of Polyamine Biosynthesis in Eukaryotic Organisms

1972 • 129 citations

A review of isozymes in cancer.

1971 • 128 citations

Translational control of protein synthesis during the early stages of differentiation of the slime mold dictyostelium discoideum

1977 • 125 citations

Some thoughts on the nature of ectopic parathyroid hormones

1971 • 124 citations

Proteins associated with globin messenger RNA in avian erythroblasts: Isolation and comparison with the proteins bound to nuclear messenger‐likie RNA

1971 • 120 citations

A Glutamine-dependent Enzyme for the Synthesis of Carbamyl Phosphate for Pyrimidine Biosynthesis in Fetal Rat Liver

1967 • 119 citations

Isozymes And Cancer

1973 • 113 citations

The roles of the polyamines, putrescine, spermidine, and spermine in normal and malignant tissues

1973 • 109 citations

Regulation of ornithine decarboxylase in 3T3 cells by putrescine and spermidine. Indirect evidence for translational control

1975 • 108 citations

Expression of an oncodevelopmental gene product (alpha-fetoprotein) during fetal development and adult oncogenesis.

1976 • 107 citations

A membrane antigen common to human cancer and fetal brain tissues.

1976 • 106 citations

Lactate dehydrogenase activity in the preimplanted mouse embryo

1965 • 105 citations

Kinetic, electrophoretic, and chromatographic studies on glucose-ATP phosphotransferases in rat hepatomas.

1969 • 104 citations

Developmental phase-specific alkaline phosphatase isoenzymes of human placenta and their occurrence in human cancer.

1976 • 102 citations

Phosphate-dependent glutaminase from rat kidney

1976 • 99 citations

Early appearance of embryonic -globulin in rat serum during carcinogenesis with 4-dimethylaminoazobenzene.

1971 • 98 citations

Control of synthesis of lactic acid dehydrogenases

1966 • 98 citations

Glycolysis of quiescent cultures of 3T3 cells. Addition of serum, epidermal growth factor, and insulin increases the activity of phosphofructokinase in a protein synthesis-independent manner.

1978 • 97 citations

Isozyme studies on adult, regenerating, precancerous and developing liver in relation to findings in hepatomas

1972 • 96 citations

Stimulation of ornithine decarboxylase synthesis and its control by polyamines in regenerating rat liver and cultured rat hepatoma cells.

1976 • 94 citations

Hexokinase isozyme patterns of experimental hepatomas of rats.

1969 • 88 citations

Lactate dehydrogenase isozymes in the early mouse embryo

1967 • 88 citations

A study on the dimeric structure of creatine kinase (EC 2.7.3.2)

1977 • 85 citations

Cancer, retrodifferentiation, and the myth of Faust.

1976 • 84 citations

Detection of multiple forms of rat liver ornithine decarboxylase.

1977 • 82 citations

ISOENZYMES AND ONTOGENY

1972 • 82 citations

NINETEENTH CENTURY FOUNDATIONS OF CANCER RESEARCH ADVANCES IN TUMOR PATHOLOGY, NOMENCLATURE, AND THEORIES OF ONCOGENESIS.

1965 • 80 citations

Reaction of Serum from Pregnant Hamsters with Surface of Cells Transformed by SV40

1970 • 79 citations

Rat liver phosphofructokinase isozymes

1974 • 78 citations

Expression of differentiated functions in hepatoma cell hybrids

1972 • 78 citations

Purification and properties of rat skeletal muscle hexokinase

1976 • 76 citations

Induction of thymidine kinases in phytohaemagglutinin-stimulated human lymphocytes

1977 • 75 citations

Fetal-type isoenzymes in hepatic and nonhepatic rat tumors.

1972 • 73 citations

Production of monospecific antibodies to rat liver ornithine decarboxylase and their use in turnover studies.

1977 • 70 citations

Pyruvate Kinase Isozymes from Rat Tissues

1973 • 67 citations

The extensive homology between mRNA sequences of normal and SV40-transformed human fibroblasts

1977 • 66 citations

On the tissue specificity and biological significance of aldolase C in the chicken

1967 • 63 citations

Human enolase isozymes: electrophoretic and biochemical evidence for three loci

1976 • 63 citations

Human alpha-feto-protein.

1972 • 62 citations

Glutamine-dependent Carbamyl Phosphate Synthetase

1970 • 60 citations

EVOLUTION OF α‐FETOPROTEIN SERUM LEVELS THROUGHOUT LIFE IN HUMANS AND RATS, AND DURING PREGNANCY IN THE RAT*

1975 • 60 citations

Glycolytic isoenzymes and glycogen metabolism in regenerating liver from rats on controlled feeding schedules

1973 • 59 citations

Metabolic regulation and enzyme alterations in the Morris hepatomas.

1968 • 57 citations

ISOZYME PATTERNS OF BRANCHED‐CHAIN AMINO ACID TRANSAMINASE DURING CELLULAR DIFFERENTIATION AND CARCINOGENESIS

1975 • 57 citations

Differences in the cytoplasmic distribution of newly synthesized poly(A) in serum-stimulated and resting cultures of BALB/c 3T3 cells

1975 • 57 citations

Regulation of lactate dehydrogenase levels in the mouse.

1978 • 56 citations

α‐FETOPROTEIN AND EARLY HISTOLOGICAL CHANGES OF HEPATIC TISSUE IN DAB‐HEPATOCARCINOGENESIS*

1975 • 55 citations

Multiple forms of uridine kinase in normal and neoplastic rat liver

1971 • 55 citations

Mitochondrial forms of glucose 6-phosphate dehydrogenase and 6-phosphogluconic acid dehydrogenase in rat liver

1967 • 54 citations

Evidence for a postsynthetic proteolytic transformation of human erythrocyte pyruvate kinase into L‐type enzyme

1977 • 53 citations

Resurgence of two Fetal-type of aldolases (A and C) in some fast-growing hepatomas

1970 • 51 citations

Comparison of the properties of two forms of pyruvate kinase in rat liver and determination of their separate activities during development

1972 • 51 citations

Enolase: human tissue distribution and evidence for three different loci*

1976 • 50 citations

Expression of teratoma-associated antigens on murine ova and early embryos

1976 • 50 citations

Two interconvertible forms of L-type pyruvate kinase from rat liver

1973 • 49 citations

Antigens associated with normal and malignant gastrointestinal tissues.

1976 • 48 citations

Pyruvate kinase isozymes in man

1976 • 48 citations

Bovine pyruvate kinase isozymes and hybrid isozymes

1976 • 48 citations

An electrophoretic study of the distribution and properties of human hexokinases

1975 • 46 citations

Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma

1977 • 45 citations

PYRUVATE KINASE ISOZYMES IN NEURONS, GLIA, NEUROBLASTOMA, AND GLIOBLASTOMA

1976 • 45 citations

Inhibition of ornithine decarboxylase by diamines in regenerating rat liver Evidence for direct action on the accumulation of the enzyme protein

1977 • 45 citations

Purification and physiological role of a peptide stabilizing factor of rat liver phosphofructokinase.

1976 • 44 citations

Multiple molecular forms of lactate dehydrogenase and glucose 6-phosphate dehydrogenase in normal and abnormal human breast tissues

1976 • 43 citations

Embryonic Enzyme Patterns: Characterization of the Single Lactate Dehydrogenase Isozyme in Preimplanted Mouse Ova

1967 • 43 citations

Fetal pattern of aldolase in transplantable hepatomas.

1971 • 43 citations

Activities and isoenzyme patterns of some enzymes of glucose metabolism in human primary malignant hepatoma.

1973 • 42 citations

Pyruvate Kinase Isozyme Changes in Parenchymal Cells of Regenerating Rat Liver

1974 • 41 citations

Polyamine metabolism in enucleated mouse L‐cells

1977 • 41 citations

The ontogeny of mammalian fructose-i,6-diphosphate aldolase

1968 • 40 citations

Pyridoxal 5′‐Phosphate and the Regulation of Ornithine Decarboxylase Activity and Stability

1976 • 40 citations

Multiple forms of phosphofructokinase in rat tissues and rat tumors

1972 • 40 citations

α‐FETOPROTEIN AND ALBUMIN SYNTHESIS DURING THE CELL CYCLE

1975 • 39 citations

Irreversible fixation of increased level of muscle type aldolase activity appearing in rat liver in the early stage of hepatocarcinogenesis.

1970 • 39 citations

Characterization fo a macromolecular inhibitor of polypeptide chain initiation from ehrlich ascites tumor cells

1976 • 39 citations

The production of creatine kinase isozyme BB in sera of a patient with prostatic carcinoma and in tumor homogenates

1978 • 38 citations

A HEPATOMA‐ASSOCIATED ALKALINE PHOSPHATASE, THE KASAHARA ISOZYME, COMPARED WITH ONE OF THE ISOZYMES OF FL AMNION CELLS

1975 • 38 citations

Pyruvate kinase isoenzymes in adult and fetal tissues of chicken

1975 • 37 citations

Biochemical changes in preneoplastic rodent intestines.

1976 • 36 citations

The presence of “fetal” thymidine kinase in human tumors

1972 • 36 citations

TUMOR‐SPECIFIC ALKALINE PHOSPHATASE IN HEPATOMA

1975 • 35 citations

Changes in gene expression accompanying neoplastic transformation of Syrian hamster cells.

1978 • 35 citations

Developmental Variation in the Isoenzymes of Human Liver and Gastric Alcohol Dehydrogenase

1971 • 35 citations

Control of ribonucleotide reductase in mammalian cells

1976 • 35 citations

Alkaline phosphatase isoenzymes in intestinal metaplasia and carcinoma of the stomach.

1976 • 33 citations

Electrofocusing and kinetic studies of adult and embryonic chicken pyruvate kinases

1976 • 32 citations

CLINICAL SIGNIFICANCE OF α‐FETOPROTEIN IN HEPATITIS AND LIVER CIRRHOSIS

1975 • 32 citations

Patterns of gene expression during teleost embryogenesis: Lactate dehydrogenase isozyme ontogeny in the medaka (Oryzias iatipes)

1977 • 31 citations

The source of lactate dehydrogenase in preimplantation mouse embryos

1971 • 31 citations

Pyruvate Kinase Isozymes in Various Tissues of Rat, and Increase of Spleen-type Pyruvate Kinase in Liver by Injecting Chromatins from Spleen and Tumor

1976 • 30 citations

α-Foetoprotein in Rats with Hepatomas Induced by Aflatoxin B1

1972 • 30 citations

γ‐Glutamyltranspeptidase activity in normal, regenerating and malignant hepatocytes

1978 • 30 citations

Characteristics of alkaline phosphatase from two continuous lines of human choriocarcinoma cells

1977 • 30 citations

Isozyme patterns of pyruvate kinase in various primary liver tumors induced during the process of hepatocarcinogenesis.

1974 • 29 citations

The identity of the aldolases isolated from rat muscle and primary hepatoma

1970 • 29 citations

Resolution of two ATP:D-hexose 6-phosphotransferase bands by starch-gel electrophoresis

1968 • 27 citations

Undifferentiated Patterns of Key Carbohydrate-Metabolizing Enzymes in Injured Livers. I. Acute Carbon-Tetrachloride Intoxication of Rat

1976 • 27 citations

Alpha-fetoprotein synthesis in tissue culture of human testicular tumors and an examination of experimental yolk sac tumors in the rat.

1976 • 26 citations

Brain isoenzyme of creatine kinase. II. Species specificity of enzyme and presence of inactive form in striated muscle of rabbit and man.

1977 • 26 citations

α‐FETOPROTEIN IN YOLK SAC TUMOR

1975 • 26 citations

Location of adult and fetal aldolases A, B, and C by immunoperoxidase technique in LF fast-growing rat hepatomas.

1978 • 24 citations

LACTATE DEHYDROGENASE ACTIVITY IN THE OOCYTES OF MAMMALS

1968 • 23 citations

Lactate dehydrogenase subunits in normal and neoplastic tissues of the rat.

1969 • 22 citations

Extraction of a factor from Ehrlich ascites tumor cells that increases the activity of the fetal isozyme of pyruvate kinase in mouse liver.

1975 • 22 citations

Fetal antigens in nonneoplastic conditions.

1976 • 22 citations

Uridine kinase activities in normal and neoplastic lymphoid cells.

1977 • 22 citations

Effect of malignant growth on the organ lactic dehydrogenase in the human

1965 • 22 citations

Lactic Dehydrogenase Activity in Preimplantation Rat Embryo

1967 • 21 citations

Activation of developmental genes in neoplastic transformation.

1976 • 20 citations

Post-transcriptional regulation of catalase synthesis in rat liver and hepatoma: Factors activating and inhibiting catalase synthesis

1973 • 20 citations

Distribution of hepatic phosphofructokinase isozymes in parenchymal and sinusoidal cells

1978 • 20 citations

Pyruvate kinase isoenzymes in tissues of the developing guinea pig

1975 • 20 citations

5-azacytidine-modified patterns of uridine kinase activities in normal and neoplastic tissues.

1974 • 19 citations

CARCINOFETAL ALTERATIONS IN GLYCOGEN PHOSPHORYLASE ISOZYMES IN RAT HEPATOMAS*

1975 • 18 citations

Lactate dehydrogenase isoenzymes in the mammalian egg: Investigations by micro disc electrophoresis in 15 species of the orders Rodentia, Lagomorpha, Carnivora, Artiodactyla and in man

1973 • 17 citations

Genetically determined polymorphism of a form of hexokinase, HK III, found in human leucocytes

1975 • 17 citations

PLACENTAL ALKALINE PHOSPHATASE: REGULATION OF EXPRESSION IN CANCER CELLS*

1975 • 17 citations

The reversible expression of an adult isozyme locus, Gdc-1, in tumors of the mouse.

1976 • 17 citations

Pyruvate kinase isozymes in cells isolated from fetal and regenerating rat liver

1977 • 17 citations

Modification of hexosaminidase isozymes in rat hepatoma.

1973 • 17 citations

The lactate dehydrogenase in preimplantation mouse embryos of quackenbush and swiss mice

1971 • 17 citations

Fetal antigens in human leukemia.

1976 • 16 citations

Neoplastic alterations of glucosamine 6-phosphate synthase in rat liver

1977 • 16 citations

Hexokinase isozymes in human neoplastic and fetal tissues: The existence of hexokinase II in malignant tumors and in placenta

1975 • 15 citations

L‐LEUCINE SENSITIVE ALKALINE PHOSPHATASE ISOZYME FROM CANCER TISSUE*

1975 • 15 citations

Forms of cytosolic nicotinamide adenine dinucleotide-linked glycerol-3-phosphate dehydrogenase in normal and neoplastic mouse tissues.

1977 • 14 citations

Post-transcriptional regulation of catalase synthesis in rat liver and hepatoma: Binding of inhibiting factor(s) with polyribosomes synthesizing catalase

1973 • 14 citations

Incorporation of bicarbonate-14 C into pyrimidines and into ribonucleic acid of the Novikoff ascites tumor cell.

1967 • 14 citations

Pyruvate kinase isoenzymes in tissues of the human fetus

1975 • 13 citations

Hexokinase isoenzymes in tissues of the adult and developing guinea pig

1976 • 13 citations

The Isoenzymes of Hexokinase in Normal and Neoplastic Tissues of the Rat

1972 • 13 citations

Les isozymes de la phosphofructokinase humaine

1972 • 13 citations

Hybrid isozymes of pyruvate kinase appear during avian cardiac development

1978 • 13 citations

The effect of environment on lactate dehydrogenase isozymes of cultured somatic cells

1971 • 12 citations

Immunological specificity of the isoenzymes I and III of human hexokinase (ATP:D-hexose 6-phosphotransferase EC 2.7.1.1) Estimation of isoenzyme pattern by quantitative immunotechniques

1974 • 12 citations

Distribution of Lactate Dehydrogenase and its Subunits in Rat Tissues and Tumors

1972 • 12 citations

Gene activation of molecules with carcinoembryonic antigen determinants in fetal development and in adenocarcinoma of the colon.

1976 • 11 citations

Kinetics of oxygen-induced changes in lactate dehydrogenase isoenzymes of human lymphocytes in culture

1969 • 10 citations

Biochemical changes in premalignant intestines.

1976 • 10 citations

A Glucose-6-Phosphate Dehydrogenase Isoenzyme Characteristic of Preneoplastic and Neoplastic Mouse Mammary Tissue 2

1973 • 10 citations

Ontogenic characteristics of lactate dehydrogenase turnover in the mouse

1977 • 9 citations

Changing patterns of placental hexokinase isozymes during the course of gestation

1976 • 8 citations

Hexokinase isozyme pattern in CCl4-injured rat liver

1975 • 8 citations

Multiple forms of enolase (E.C.4.2.1.11): Their distribution in human tissues

1975 • 8 citations

Interaction of mammalian tRNA methyltransferases with heterologous and homologous tRNA

1975 • 7 citations

Membrane-bound arylamidase from human hepatoma cells having the same electrophoretic mobility as placental membrane-bound arylamidase

1978 • 7 citations

Glucose 6-phosphate-dependent binding of hexokinase to membranes of ascites tumor cells

1976 • 6 citations

Isozyme pattern of fructose diphosphate aldolase during hepatocarcinogenesis induced by 2‐acetylaminofluorene in rat liver

1975 • 6 citations

Anomalous multiplicities of lactate dehydrogenase

1968 • 6 citations

Localization of pyruvate kinase isozymes in bovine kidney and comparison of these patterns with those of lactate dehydrogenases and aldolases

1978 • 6 citations

Influence of Oxygen Tension on Lactate Dehydrogenase and Aldolase Activities in Chang Liver Cells.

1967 • 5 citations

Effect of controlled feeding on the isoenzymes of pyruvate kinase, hexokinase and aldolase in liver during development

1974 • 5 citations

Studies on the enzymology of the rhabdomyosarcoma induced by the murine sarcoma virus (Moloney).

1970 • 3 citations

A case of minimal deviation hepatoma in man with elevated liver-type pyruvate kinase isozyme

1977 • 2 citations

Resurgence of two fetal aldolases in rat duodenal adenocarcinomas.

1975 • 1 citations