Retarded Axonal Transport of R406W Mutant Tau in Transgenic Mice with a Neurodegenerative Tauopathy

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Neurodegenerative Tauopathies

2001 • 2,276 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

2000 • 1,311 citations

Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17

1998 • 954 citations

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

2002 • 843 citations

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

1999 • 552 citations

Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons

1997 • 517 citations

Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements

1999 • 506 citations

Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assembly

1998 • 469 citations

Tau Filament Formation in Transgenic Mice Expressing P301L Tau

2001 • 465 citations

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

1998 • 464 citations

High Prevalence of Mutations in the Microtubule-Associated Protein Tau in a Population Study of Frontotemporal Dementia in the Netherlands

1999 • 419 citations

Frontotemporal Dementia and Corticobasal Degeneration in a Family with a P301S Mutation in Tau

1999 • 418 citations

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.

1996 • 397 citations

Prominent Axonopathy in the Brain and Spinal Cord of Transgenic Mice Overexpressing Four-Repeat Human tau Protein

1999 • 378 citations

Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein

2000 • 355 citations

Structure, Microtubule Interactions, and Paired Helical Filament Aggregation by Tau Mutants of Frontotemporal Dementias

2000 • 337 citations

5′ Splice Site Mutations in tau Associated with the Inherited Dementia FTDP-17 Affect a Stem-Loop Structure That Regulates Alternative Splicing of Exon 10

1999 • 294 citations

Neurofilaments and Orthograde Transport Are Reduced in Ventral Root Axons of Transgenic Mice that Express Human SOD1 with a G93A Mutation

1997 • 293 citations

Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene

2000 • 264 citations

Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau

2002 • 251 citations

Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17

1999 • 247 citations

Segregation of a Missense Mutation in the Microtubule-Associated Protein Tau Gene with Familial Frontotemporal Dementia and Parkinsonism

1998 • 236 citations

Neurodegeneration with Tau Accumulation in a Transgenic Mouse Expressing V337M Human Tau

2002 • 229 citations

Phenotypic variation in hereditary frontotemporal dementia with tau mutations

1999 • 222 citations

TauGene Mutation G389R Causes a Tauopathy with Abundant Pick Body-like Inclusions and Axonal Deposits

1999 • 204 citations

FTDP‐17 mutations N279K and S305N in tau produce increased splicing of exon 10

1999 • 203 citations

Phosphorylation of tau by glycogen synthase kinase-3β in intact mammalian cells: The effects on the organization and stability of microtubules

1996 • 198 citations

FTDP-17 Mutations in tau Transgenic Mice Provoke Lysosomal Abnormalities and Tau Filaments in Forebrain

2001 • 196 citations

Autosomal dominant dementia with widespread neurofibrillary tangles

1997 • 179 citations

Abnormal Tau-Containing Filaments in Neurodegenerative Diseases

2000 • 177 citations

A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy

1999 • 170 citations

Age-Dependent Induction of Congophilic Neurofibrillary Tau Inclusions in Tau Transgenic Mice

2001 • 166 citations

TauGene Mutation K257T Causes a Tauopathy Similar to Pick's Disease

2000 • 160 citations

A noveltau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies

2000 • 137 citations

Pick's disease is associated with mutations in thetau gene

2000 • 135 citations

Distinct FTDP-17 Missense Mutations in Tau Produce Tau Aggregates and Other Pathological Phenotypes in Transfected CHO Cells

2000 • 127 citations

A novel mutation at position +12 in the intron following Exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto)

2000 • 109 citations

Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo

1995 • 92 citations

Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits.

1995 • 88 citations

A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration

1999 • 82 citations

Attenuated Neurodegenerative Disease Phenotype in Tau Transgenic Mouse Lacking Neurofilaments

2001 • 71 citations

The FTDP‐17‐Linked Mutation R406W Abolishes the Interaction of Phosphorylated Tau with Microtubules

2000 • 67 citations

The Slow Axonal Transport of the Microtubule-Associated Protein Tau and the Transport Rates of Different Isoforms and Mutants in Cultured Neurons

2002 • 66 citations

Unhampered Prion Neuroinvasion despite Impaired Fast Axonal Transport in Transgenic Mice Overexpressing Four-Repeat Tau

2002 • 66 citations

Molecular Analysis of Mutant and Wild-Type Tau Deposited in the Brain Affected by the FTDP-17 R406W Mutation

2001 • 58 citations

Functional Characterization of FTDP-17 tau Gene Mutations through Their Effects on Xenopus Oocyte Maturation

2002 • 50 citations

Missense point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: A novel action of R406W mutation

2000 • 39 citations

Effects of FTDP‐17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3β identified by mass spectrometry demonstrate certain mutations exert long‐range conformational changes

2001 • 39 citations

A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies

2000 • 32 citations