Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo.

Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

1999 • 2,494 citations

Safety and antitumor activity of recombinant soluble Apo2 ligand

1999 • 2,215 citations

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

1998 • 1,548 citations

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1999 • 1,044 citations

Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5

2000 • 968 citations

Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

2000 • 847 citations

The Novel Receptor TRAIL-R4 Induces NF-κB and Protects against TRAIL-Mediated Apoptosis, yet Retains an Incomplete Death Domain

1997 • 829 citations

TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

1997 • 683 citations

NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling

2001 • 583 citations

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

2000 • 526 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) Contributes to Interferon γ–Dependent Natural Killer Cell Protection from Tumor Metastasis

2001 • 499 citations

Vitamin E: non-antioxidant roles

2000 • 485 citations

Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo.

2000 • 391 citations

Molecular determinants of response to TRAIL in killing of normal and cancer cells.

2000 • 379 citations

Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAF1/CIP1 via C/EBPβ

1997 • 340 citations

Induction of cancer cell apoptosis by α‐tocopheryl succinate: molecular pathways and structural requirements

2001 • 286 citations

Apoptosis in Human Disease: A New Skin for the Old Ceremony?

1999 • 258 citations

Selective cancer cell killing by α-tocopheryl succinate

2001 • 236 citations

Down-regulation of p21 ^WAF1/CIP1 or p27 ^Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

2000 • 227 citations

Tumor necrosis factor-related apoptosis-inducing ligand retains its apoptosis-inducing capacity on Bcl-2- or Bcl-xL-overexpressing chemotherapy-resistant tumor cells.

2000 • 201 citations

Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland)

2000 • 170 citations

CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-κB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells

2001 • 166 citations

Nuclear Factor-κB Regulates Induction of Apoptosis and Inhibitor of Apoptosis Protein-1 Expression in Vascular Smooth Muscle Cells

1999 • 165 citations

Vitamin E Succinate Promotes Breast Cancer Tumor Dormancy

2000 • 153 citations

The Role of NF-κB in TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis of Melanoma Cells

2001 • 148 citations

Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: role for Mr 43,000 Fas in VES-triggered apoptosis.

1999 • 146 citations

Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer.

2001 • 144 citations

p53 family genes: structural comparison, expression and mutation

1999 • 144 citations

The selective antiproliferative effects of alpha-tocopheryl hemisuccinate and cholesteryl hemisuccinate on murine leukemia cells result from the action of the intact compounds.

1994 • 137 citations

Doxorubicin Treatment Activates a Z-VAD-Sensitive Caspase, Which Causes ΔΨm Loss, Caspase-9 Activity, and Apoptosis in Jurkat Cells

2000 • 125 citations

α‐Tocopheryl succinate‐induced apoptosis in Jurkat T cells involves caspase‐3 activation, and both lysosomal and mitochondrial destabilisation

1999 • 125 citations

Differential display cloning identifies motility-related protein (MRP1/CD9) as highly expressed in primary compared to metastatic human colon carcinoma cells.

1997 • 111 citations

Inhibition of NF-κB Activity Enhances TRAIL Mediated Apoptosis in Breast Cancer Cell Lines

2000 • 107 citations

Vitamin E succinate inhibits proliferation of BT-20 human breast cancer cells: increased binding of cyclin A negatively regulates E2F transactivation activity.

1997 • 93 citations

Caspase-Dependent Cdk Activity Is a Requisite Effector of Apoptotic Death Events

2000 • 90 citations

Coenzyme Q blocks biochemical but not receptor‐mediated apoptosis by increasing mitochondrial antioxidant protection

2001 • 84 citations

alpha-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-kappa B mobilization

1997 • 83 citations

Choosing anticancer drug targets in the postgenomic era

1999 • 78 citations

Apoptosis and cell division

2000 • 75 citations

Inhibition of Inflammatory Endothelial Responses by a Pathway Involving Caspase Activation and p65 Cleavage

2001 • 74 citations

Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and actinomycin D induces apoptosis even in TRAIL-resistant human pancreatic cancer cells.

2001 • 68 citations

Lipoprotein-associated α-tocopheryl-succinate inhibits cell growth and induces apoptosis in human MCF-7 and HBL-100 breast cancer cells

2000 • 62 citations

Analysis of Plasminogen-Binding M Proteins of Streptococcus pyogenes

2000 • 58 citations

Transcription Abnormalities Potentiate Apoptosis of Normal Human Fibroblasts

1997 • 58 citations

c-Jun involvement in vitamin E succinate induced apoptosis of reticuloendotheliosis virus transformed avian lymphoid cells

1997 • 56 citations

Growth inhibition of MCF-7 and MCF-10A human breast cells by α-tocopheryl hemisuccinate, cholesteryl hemisuccinate and their ether analogs

1997 • 49 citations

Establishment of Human Colonic Epithelial Cells in Long-Term Culture

1996 • 39 citations

Viral Caspase Inhibitors CrmA and p35

2000 • 38 citations

Protection against carbon tetrachloride-induced hepatotoxicity by pretreating rats with the hemisuccinate esters of tocopherol and cholesterol.

1993 • 33 citations

New insights into p53 regulation and gene therapy for cancer

2000 • 33 citations

α-tocopheryl succinate protects hepatocytes from chemical-induced toxicity under physiological calcium conditions

1989 • 33 citations

Protection of zidovudine-induced toxicity against murine erythroid progenitor cells by vitamin E.

1991 • 31 citations

Effect of different oxygen pressures and N,N′-diphenyl-p-phenylenediamine on adriamycin® toxicity to cultured neonatal rat heart myocytes

1994 • 30 citations

Membrane-targeted green fluorescent protein reliably and uniquely marks cells through apoptotic death

2001 • 28 citations

Administration of the TRIS salt of α-tocopheryl hemisuccinate inactivates CYP2E1, enhances microsomal α-tocopherol levels and protects against carbon tetrachloride-induced hepatotoxicity

1999 • 22 citations