Black (air-cured) and blond (flue-cured) tobacco cancer risk IV: Molecular dosimetry studies implicate aromatic amines as bladder carcinogens

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

1989 • 643 citations

ROLE OF N-ACETYLTRANSFERASE PHENOTYPES IN BLADDER CARCINOGENESIS: A PHARMACOGENETIC EPIDEMIOLOGICAL APPROACH TO BLADDER CANCER

1982 • 501 citations

Concentration of mutagens from urine by absorption with the nonpolar resin XAD-2: cigarette smokers have mutagenic urine.

1977 • 474 citations

Human ArylamineN-Acetyltransferase Genes: Isolation, Chromosomal Localization, and Functional Expression

1990 • 429 citations

Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites

1992 • 417 citations

Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process

1985 • 373 citations

Acetylator genotype and arylamine-induced carcinogenesis

1988 • 325 citations

The epidemiology of bladder cancer.A second look

1977 • 292 citations

Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.

1990 • 291 citations

Hemoglobin adducts of 4-aminobiphenyl in smokers and nonsmokers.

1987 • 259 citations

Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities

1991 • 258 citations

Chemical Studies on Tobacco Smoke LXIV. On the Analysis of Aromatic Amines in Cigarette Smoke*

1979 • 252 citations

Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis.

1992 • 229 citations

Chemical Carcinogenesis and Mutagenesis I

1990 • 225 citations

The Primary Aromatic Amines: Their Biological Properties and Structure-Activity Relationships

1979 • 217 citations

Smoking related carcinogen-DNA adducts in biopsy samples of human urinary bladder: identification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl as a major adduct.

1991 • 211 citations

Hemoglobin adducts of aromatic amines: associations with smoking status and type of tobacco.

1988 • 192 citations

Frequency of molecular alterations affecting ras protooncogenes in human urinary tract tumors.

1985 • 191 citations

Induction of Lymphoma in CDF₁ Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

1989 • 186 citations

Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation

1991 • 184 citations

Detection of a carcinogen, 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP), in cigarette smoke condensate

1991 • 171 citations

BLADDER CANCER EPIDEMIOLOGY1

1981 • 161 citations

Analysis of hemoglobin as a dose monitor for alkylating and arylating agents

1984 • 157 citations

Mortality of gasworkers--final report of a prospective study

1972 • 157 citations

Changing Cigarette Habits and Bladder Cancer Risk: A Case-Control Study

1987 • 148 citations

Determination of mutagens, amino-α-carbolines in grilled foods and cigarette smoke condensate

1981 • 145 citations

Investigations on the Effects of Chronic Cigarette-Smoke Inhalation in Syrian Golden Hamsters

1973 • 139 citations

Relevance of metabolic polymorphisms to human carcinogenesis: evaluation of epidemiologic evidence

1991 • 138 citations

Carcinogen Hemoglobin Adducts, Urinary Mutagenicity, and Metabolic Phenotype in Active and Passive Cigarette Smokers

1990 • 133 citations

Adsorption of mutagens to cotton bearing covalently bound trisulfo-copper-phthalocyanine

1983 • 133 citations

Tobacco and bladder cancer in males: Increased risk for inhalers and smokers of black tobacco

1989 • 132 citations

Detection of carcinogen-DNA adducts in exfoliated urothelial cells of cigarette smokers: association with smoking, hemoglobin adducts, and urinary mutagenicity.

1991 • 127 citations

Assessment of tobacco-specific N-nitrosamines in tobacco products.

1979 • 126 citations

Acetylation phenotype, carcinogen-hemoglobin adducts, and cigarette smoking.

1990 • 123 citations

The pH of tobacco smoke

1974 • 118 citations

Tobacco smoking, occupational exposure and bladder cancer in Argentina

1987 • 106 citations

Mass spectrometric analysis of tobacco-specific nitrosamine hemoglobin adducts in snuff dippers, smokers, and nonsmokers.

1990 • 102 citations

Effects of timing and type of tobacco in cigarette-induced bladder cancer.

1988 • 97 citations

Amino-α-carbolines as mutagenic agents in cigarette smoke condensate

1980 • 96 citations

Investigations on the origin of tobacco-specific nitrosamines n mainstream smoke of cigarettes

1990 • 95 citations

Formation of a glutathione conjugate and a semistable transportable glucuronide conjugate of N²-oxidized species of 2-amino-1-methyl-6phenylimidazo[4,5-b]pyridine (PHIP) in rat liver

1991 • 84 citations

³²Postabelling analysis of urinary mutagens from smokers of black tobacco implicates 2-amino-1-methyl-6-phnylimidazo[4,5-b]pyridine (PhIP) as a major DNA-damaging agent

1991 • 84 citations

N-Nitroso compounds in cigarette tobacco and their occurrence in mainstream tobacco smoke

1991 • 78 citations

Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.

1991 • 76 citations

Detection and characterization of carcinogen—DNA adducts in exfoliated urothelial cells from 4-aminobiphenyl-treated dogs by ³²P-postlabelling and subsequent thin-layer and high-pressure liquid chromatography

1990 • 71 citations

DNA Modification by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine in Rats

1989 • 71 citations

Detection of 2-amino-3-methylimidazo[4,5-f]quinoline in cigarette smoke condensate.

1986 • 70 citations

Assessment of the carcinogenic N-nitrosodiethanolamine in tobacco products and tobacco smoke

1981 • 64 citations

Levels of mutagens in the urine of smokers of black and blond tobacco correlate with their risk of bladder cancer

1989 • 63 citations

Modification of DNA with potent mutacarcinogenic 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole isolated from a glutamic acid pyrolysate: structure of the modified nucleic acid base and initial chemical event caused by the mutagen

1982 • 61 citations

Induction of Intestinal Adenocarcinomas by 2‐Amino‐l‐methyl‐6‐phenylimidazo‐[4,5‐b] pyridine in Nagase Analbuminemic Rats

1991 • 60 citations

Black (air-cured) and blond (flue-cured) tobacco and cancer risk III: Oesophageal cancer

1993 • 60 citations

Metabolic activation of a mutagen, 2-amino-6-methyldipyrido-[1,2-a:3′,2′-d]imidazole. Identification of 2-hydroxyamino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole and its reaction with DNA

1980 • 60 citations

Sensitivity of Salmonella typhimurium YG1024 to urine mutagenicity caused by cigarette smoking

1990 • 57 citations

Simultaneous determination of amino-α-carbolines and amino-γ-carbolines in cigarette smoke condensate by high-performance liquid chromatography

1990 • 56 citations

Ein experimenteller Beitrag zur Tabakrauchkanzerogenese^*

1963 • 51 citations

The Copenhagen case-control study of bladder cancer: role of smoking in invasive and non-invasive bladder tumours.

1987 • 49 citations

Detection of carcinogenic glutamic acid pyrolysis products in cigarette smoke condensate

1990 • 44 citations

Metabolic Activation of Pyrolysate Arylamines by Human Liver Microsomes; Possible Involvement of a P‐448‐H Type Cytochrome P‐450

1988 • 44 citations

³²P-Postlabelling analysis of DNA adducted with urinary mutagens from smokers of black tobacco

1990 • 42 citations

Sentivivity of Salmonella typhimurium YG1024 urine mutagenicity caused by cigarrete smoking

1990 • 42 citations

Black (air-cured) and blond (flue-cured) tobacco and cancer risk II: Pharynx and larynx cancer

1993 • 40 citations

Chemical Studies on Tobacco Smoke. III. Primary and Secondary Nitroalkanes in Cigarette Smoke

1968 • 33 citations

Carcinogen-DNA adducts in exfoliated urothelial cells: techniques for noninvasive human monitoring.

1993 • 33 citations

Assessment of major carcinogens and alkaloids in the tobacco and mainstream smoke of ussr cigarettes

1991 • 28 citations

Composition of Cigarette Smoke : Some Low-Boiling Components

1962 • 27 citations

Chemical Studies on Tobacco Smoke LXVI. Comparative Assessment of Volatile and Tobacco-Specific N-Nitrosamines in the Smoke of Selected Cigarettes From the U.S.A., West Germany and France.

1980 • 27 citations

2-Aminofluorene-DNA adducts in mouse urinary bladder: effect of age, sex and acetylator phenotype

1992 • 26 citations

Tobacco-specific nitrosamines in mainstream smoke of West Gennan cigarettes-tar alone is not a sufficient index for the carcinogenic potential of cigarette smoke

1989 • 23 citations

Evidence that a hemoglobin adduct of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a 4-(3-pyridyl)-4-oxobutyl carboxylic acid ester

1992 • 22 citations

Modification of nucleic acids with muta-carcinogenic heteroaromatic amines in vivo

1982 • 21 citations

Interindividual variation in carcinogen metabolism and bladder cancer risk.

1992 • 20 citations

Haemoglobin adducts formed by aromatic amines in smokers: sources of inter-individual variability

1990 • 16 citations

Black (air-cured) and blond (flue-cured) tobacco and cancer risk VI: Lung cancer

1993 • 15 citations

Carcinogen-DNA Adducts in Exfoliated Urothelial Cells: Techniques for Noninvasive Human Monitoring

1993 • 9 citations

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