Loop–loop interaction of HIV-1 TAR RNA with N3′ → P5′ deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription

A Novel CDK9-Associated C-Type Cyclin Interacts Directly with HIV-1 Tat and Mediates Its High-Affinity, Loop-Specific Binding to TAR RNA

1998 • 1,213 citations

Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

1987 • 902 citations

HIV-1 tat trans-activation requires the loop sequence within tar

1988 • 551 citations

Aptamers as therapeutic and diagnostic agents

2000 • 490 citations

Fragments of the HIV-1 Tat Protein Specifically Biand TAR RNA

1990 • 446 citations

Multifaceted Activities of the HIV-1 Transactivator of Transcription, Tat

1999 • 411 citations

Tackling tat

1999 • 375 citations

The Structure of the Human Immunodeficiency Virus Type-1 TAR RNA Reveals Principles of RNA Recognition by Tat Protein

1995 • 360 citations

Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat.

1989 • 357 citations

High Affinity Binding of TAR RNA by the Human Immunodeficiency Virus Type-1 tat Protein Requires Base-pairs in the RNA Stem and Amino Acid Residues Flanking the Basic Region

1993 • 281 citations

An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication

1997 • 241 citations

Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription

1999 • 172 citations

Biochemical and Functional Interactions between HIV-1 Tat Protein and TAR RNA

1999 • 170 citations

Targeting RNA with Small Molecules

2000 • 145 citations

Measurement of intracellular (compartmental) pH by 31P NMR in Aspergillus niger

2000 • 144 citations

The structure of an RNA “kissing” hairpin complex of the HIV TAR hairpin loop and its complement

1997 • 135 citations

In vitro selection identifies key determinants for loop–loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1

1999 • 129 citations

Tat Transactivation: A Model for the Regulation of Eukaryotic Transcriptional Elongation

1999 • 128 citations

Inhibition of HIV-1 Tat-Dependent Trans Activation by Steric Block Chimeric 2‘-O-Methyl/LNA Oligoribonucleotides

2001 • 122 citations

DNA Aptamers Selected Against the HIV-1trans-Activation-responsive RNA Element Form RNA-DNA Kissing Complexes

1999 • 113 citations

The solution structure of an RNA loop–loop complex: the ColE1 inverted loop sequence

1998 • 100 citations

Dimerization of HIV-1 genomic RNA of subtypes A and B: RNA loop structure and magnesium binding

1999 • 89 citations

Is a Closing “GA Pair” a Rule for Stable Loop-Loop RNA Complexes?

2000 • 87 citations

Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex.

1996 • 86 citations

Determinants of RNA Hairpin Loop-Loop Complex Stability

1995 • 81 citations

Oligo-2'-fluoro-2'-deoxynucleotide N3'-->P5' phosphoramidates: synthesis and properties

1996 • 77 citations

Inhibition of Tat-Mediated Transactivation of HIV-1 LTR Transcription by Polyamide Nucleic Acid Targeted to TAR Hairpin Element

2000 • 65 citations

N3‘→P5‘ Oligodeoxyribonucleotide Phosphoramidates: A New Method of Synthesis Based on a Phosphoramidite Amine-Exchange Reaction

1997 • 44 citations

OLIGONUCLEOTIDE ANALOGUE INTERFERENCE WITH THE HIV-1 TAT PROTEIN-TAR RNA INTERACTION

2001 • 43 citations

Oligonucleotide inhibition of the interaction of HIV-1 Tat protein with the trans-activation responsive region (TAR) of HIV RNA

1999 • 31 citations

Modulation of RNA function by oligonucleotides recognizing RNA structure

2001 • 31 citations

NMR Solution Structure of the N3‘ → P5‘ Phosphoramidate Duplex d(CGCGAATTCGCG)₂ by the Iterative Relaxation Matrix Approach

1998 • 26 citations

Use of the Fluorescent Nucleoside Analogue Benzo[g]quinazoline 2′-O-Methyl--D-ribofuranoside to Monitor the Binding of the HIV-1 Tat Protein or of Antisense Oligonucleotides to the TAR RNA Stem-Loop

2000 • 25 citations

Novel HIV Tat antagonists

2000 • 12 citations