Optimization of Hydrophobic Domains in Peptides that Undergo Transformation from α-Helix to β-Fibril

Prediction of protein conformation

1974 • 3,327 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Thioflavine T interaction with synthetic Alzheimer's disease β‐amyloid peptides: Detection of amyloid aggregation in solution

1993 • 2,137 citations

Molecular Biology of Prion Diseases

1991 • 1,978 citations

Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl .alpha.-chymotrypsin using different denaturants

1988 • 1,568 citations

X-Ray Structure of the GCN4 Leucine Zipper, a Two-Stranded, Parallel Coiled Coil

1991 • 1,433 citations

NMR structure of the mouse prion protein domain PrP(121–231)

1996 • 1,251 citations

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

1997 • 1,041 citations

Prion Diseases and the BSE Crisis

1997 • 952 citations

Transition Metal Nanocluster Formation Kinetic and Mechanistic Studies. A New Mechanism When Hydrogen Is the Reductant: Slow, Continuous Nucleation and Fast Autocatalytic Surface Growth

1997 • 872 citations

Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin.

1987 • 849 citations

Responsive gels formed by the spontaneous self-assembly of peptides into polymeric β-sheet tapes

1997 • 838 citations

Amyloid β-Protein and the Genetics of Alzheimer's Disease

1996 • 794 citations

Solid phase peptide synthesis; a practical approach

1991 • 772 citations

NMR characterization of the full‐length recombinant murine prion protein, mPrP(23–231)

1997 • 720 citations

Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation.

1989 • 599 citations

Alternative conformations of amyloidogenic proteins govern their behavior

1996 • 596 citations

Prion (PrPSc)-specific epitope defined by a monoclonal antibody

1997 • 565 citations

The Acid-Mediated Denaturation Pathway of Transthyretin Yields a Conformational Intermediate That Can Self-Assemble into Amyloid

1996 • 546 citations

Amphiphilic Secondary Structure: Design of Peptide Hormones

1984 • 541 citations

Context-dependent secondary structure formation of a designed protein sequence

1996 • 395 citations

Templates That Induce .alpha.-Helical, .beta.-Sheet, and Loop Conformations

1995 • 348 citations

A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform 1 1Edited by M. Yaniv

1997 • 340 citations

Physical, Morphological and Functional Differences between pH 5.8 and 7.4 Aggregates of the Alzheimer's Amyloid Peptide A β

1996 • 329 citations

Specific aggregation of partially folded polypeptide chains: The molecular basis of inclusion body composition

1996 • 307 citations

Non-native α-helical intermediate in the refolding of β-lactoglobulin, a predominantly β-sheet protein

1996 • 259 citations

Selective Inhibition of Aβ Fibril Formation

1996 • 229 citations

Direct conversion of an oligopeptide from a β-sheet to an α-helix: A model for amyloid formation

1997 • 192 citations

Prionics or The kinetic basis of prion diseases

1996 • 181 citations

Protein alchemy: Changing β-sheet into α-helix

1997 • 174 citations

High Helical Propensity of the Peptide Fragments Derived from β-Lactoglobulin, a Predominantly β-sheet Protein

1995 • 173 citations

X-ray Diffraction of Scrapie Prion Rods and PrP Peptides

1995 • 165 citations

For Protein Misassembly, It's the “I” Decade

1996 • 153 citations

The prion folding problem

1997 • 151 citations

De novo protein design: from molten globules to native-like states

1993 • 145 citations

Solution Structure of α₂D, a Nativelike de Novo Designed Protein

1998 • 136 citations

The Burst-phase Intermediate in the Refolding of β-Lactoglobulin Studied by Stopped-flow Circular Dichroism and Absorption Spectroscopy

1996 • 126 citations

A chemical approach to elucidate tin mechanism of transthyretin and β-protein amyloid fibril formation

1994 • 124 citations

Redox control of secondary structure in a designed peptide

1993 • 113 citations

Conformational switching in designed peptides: the helix/sheet transition

1996 • 111 citations

A Reductionist View of Alzheimer's Disease

1996 • 107 citations

Metal Ion Induced Folding of a de Novo Designed Coiled-Coil Peptide

1998 • 97 citations

Switch Peptides: pH‐Induced α‐Helix to β‐Sheet Transitions of Bis‐amphiphilic Oligopeptides

1991 • 94 citations

Native-like and structurally characterized designed α-helical bundles

1995 • 90 citations

Peptides as Conformational Switch: Medium‐Induced Conformational Transitions of Designed Peptides

1990 • 85 citations

Redox-Triggered Secondary Structure Changes in the Aggregated States of a Designed Methionine-Rich Peptide

1996 • 84 citations

High helicity of peptide fragments corresponding to β-strand regions of β-lactoglobulin observed by 2D-NMR spectroscopy

1996 • 76 citations

Folding intermediates are involved in genetic diseases?

1995 • 75 citations

Engineering peptides and proteins that undergo α-to-β transitions

1997 • 75 citations

Design of a Peptide Undergoing α-β Structural Transition and Amyloid Fibrillogenesis by the Introduction of a Hydrophobic Defect

1998 • 61 citations

Kinetics and mechanism of amyloid formation by the prion protein H1 peptide as determined by time-dependent ESR

1997 • 58 citations

Nucleated Antiparallel β-Sheet That Folds and Undergoes Self-Assembly: A Template Promoted Folding Strategy toward Controlled Molecular Architectures

1996 • 52 citations

Amyloid in alzheimer's disease and prion-related encephalopathies: Studies with synthetic peptides

1996 • 50 citations

Putting Prions to the Test

1996 • 47 citations

Synthesis of LH-RH using a new phenolic polymer as solid support and “BOP” reagent for fragment coupling

1980 • 35 citations

Disulfide bond formation in S-Acetamidomethyl cysteine-containing peptides by the combination of silver trifluoromethanesulfonate and dimethylsulfoxide / aqueous HCl

1993 • 32 citations

Predisposition of prion protein homozygotes to Creutzfeldt-Jakob disease can be explained by a nucleation-dependent polymerization mechanism

1994 • 28 citations

Autocatalytic processes in cooperative mechanisms of prion diseases

1997 • 28 citations

Introduction of a Trp residue into .alpha.4 as a probe of dynamics

1993 • 24 citations

Deprotection of the S-trimethylacetamidomethyl (Tacm) group using silver tetrafluoroborate: Application to the synthesis of porcine brain natriuretic peptide-32(pBNP-32).

1990 • 21 citations

Haem binding and catalytic activity of two-α-helix peptide annealed by trifluoroethanol

1997 • 18 citations

Super-Secondary Structure with Amphiphilic β-Strands Probed by Pyrenylalanine

1995 • 13 citations

Support Builds for Curbs on Lifetime Faculty Posts

1996 • 6 citations

Has CERN Made the Stuff of the Newborn Universe?

1996 • 5 citations