In vivo expression of the CTLA4 inhibitory receptor in malignant and reactive cells from Human lymphomas

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

1990 • 745 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

Intracellular Trafficking of CTLA-4 and Focal Localization Towards Sites of TCR Engagement

1996 • 583 citations

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.

1995 • 489 citations

CTLA4 mediates antigen-specific apoptosis of human T cells.

1995 • 331 citations

Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity.

1995 • 224 citations

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.

1993 • 207 citations

CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response.

1996 • 198 citations

CD28 and apoptosis

1995 • 147 citations

Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.

1996 • 128 citations

In vivo expression of the B7 costimulatory molecule by subsets of antigen-presenting cells and the malignant cells of Hodgkin's disease

1994 • 102 citations

The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen

1994 • 83 citations

The B7/BB1 antigen is expressed by Reed-Sternberg cells of Hodgkin's disease and contributes to the stimulating capacity of Hodgkin's disease-derived cell lines

1993 • 80 citations

Activated T cells can induce high levels of CTLA-4 expression on B cells.

1995 • 78 citations

Description of a sequential staining procedure for double immunoenzymatic staining of pairs of antigens using monoclonal antibodies

1986 • 51 citations

Lymphocyte activation: T-cell regulation by CTLA-4

1996 • 49 citations

Malignant B lymphocytes from non‐Hodgkin's lymphoma induce allogeneic proliferative and cytotoxic T cell responses in primary mixed lymphocyte cultures: An important role of co‐stimulatory molecules CD80 (B7‐1) and CD86 (B7‐2) in stimulation by tumor cells

1995 • 46 citations

A novel monoclonal antibody (FUN‐1) identifies an activation antigen in cells of the B‐cell lineage and Reed—Sternberg cells

1993 • 34 citations

The Antigen-Presenting Cell Function of Reed-Sternberg Cells

1995 • 27 citations

Apoptotic signaling in lymphocytes

1996 • 15 citations

Heterogeneity of Rearranged T-Cell Receptor V-αand V-βTranscripts in Tumor-infiltrating Lymphocytes from Hodgkin’s Disease and Non-Hodgkin’s Lymphoma

1994 • 13 citations

Accumulation of CTLA-4 expressing T lymphocytes in the germinal centers of human lymphoid tissues

1997 • 2 citations

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