Enhancement of experimental metastasis by pretreatment of tumour cells with hydroxyurea

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

The Will Rogers Phenomenon

1985 • 1,512 citations

Selection of Successive Tumour Lines for Metastasis

1973 • 1,360 citations

Mutation selection and the natural history of cancer

2006 • 1,185 citations

Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation.

1974 • 775 citations

Cancer. A Comprehensive Treatise

1975 • 742 citations

Errors in DNA replication as a basis of malignant changes.

1974 • 527 citations

The experimental study of tumor progression: a review.

1954 • 522 citations

The relationship of embolic homogeneity, number, size and viability to the incidence of experimental metastasis

1973 • 406 citations

Mutagenicity Testing: A Practical Approach

1986 • 299 citations

Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms.

1981 • 291 citations

Effects of Hydroxyurea and 1‐β‐D‐Arabinofuranosyl‐cytosine on Deoxyribonucleotide Pools in Mouse Embryo Cells

1971 • 280 citations

Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test.

1977 • 263 citations

Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosarcoma of recent origin.

1978 • 248 citations

Hydroxyurea

1975 • 234 citations

Enhancement of Methotrexate Resistance and Dihydrofolate Reductase Gene Amplification by Treatment of Mouse 3T6 Cells with Hydroxyurea

1983 • 191 citations

Mutagenicity—New Horizons in Genetic Toxicology

1983 • 173 citations

Induction of morphological transformation in mouse C3H/10T1/2 clone 8 cells and chromosomal damage in hamster A(T1)C1-3 cells by cancer chemotherapeutic agents.

1977 • 155 citations

Enhanced Metastatic Potential of Tumor Cells Harvested From Spontaneous Metastases of Heterogeneous Murine Tumors<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>

1982 • 133 citations

UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.

1984 • 130 citations

Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea.

1983 • 118 citations

Mutagenic responses of thirteen anticancer drugs on mutation induction at multiple genetic loci and on sister chromatid exchanges in Chinese hamster ovary cells.

1983 • 117 citations

Tumorigenicity in vivo and induction of malignant transformation and mutagenesis in cell cultures by adriamycin and daunomycin.

1976 • 102 citations

Enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection

1975 • 101 citations

Gradual transformation of solid into ascites tumors. Evidence favoring the mutation-selection theory

1955 • 78 citations

Platinum(II) complexes generate frame-shift mutations in test strains of Salmonella typhimurium

1979 • 53 citations

Mutagenicity Testing with Cultured Mammalian Cells: Cytogenetic Assays

1982 • 50 citations

Metastasis of a transplantable mammary tumour in rats treated with cyclophosphamide and/or irradiation

1977 • 40 citations

Enhancement by cytotoxic agents of artificial pulmonary metastasis

1977 • 39 citations

Relevance of density, size and DNA content of tumour cells to the lung colony assay

1977 • 37 citations

FACILITATION OF TUMOUR PROGRESSION BY CANCER THERAPY

1982 • 34 citations

Amplified pulmonary metastases of a rat rhabdomyosarcoma in response to nitrosourea treatment.

1984 • 33 citations

Fifth Gordon Hamilton-Fairley memorial lecture. Methotrexate resistance and gene amplification: An experimental model for the generation of cellular heterogeneity

1985 • 27 citations

Enhancement of artificial lung metastases in mice caused by cyclophosphamide

1979 • 20 citations

Enhancement of experimental lung metastases by cultured B16 melanoma cells treated with (+/-)-1,2-bis(3,5-dioxopiperazin-1-y)propane (ICRF-159).

1978 • 12 citations

Enhanced cloning efficiency of murine rhabdomyosarcoma cells after chlorozotocin treatment: relationship with enhanced lung metastasis.

1985 • 4 citations

Enhanced Cloning Efficiency of Murine Rhabdomyosarcoma Cells After Chlorozotocin Treatment: Relationship With Enhanced Lung Metastasis

1985 • 3 citations