Cytotoxicity of activated rat macrophages against syngeneic islet cells is arginine-dependent, correlates with citrulline and nitrite concentrations and is identical to lysis by the nitric oxide donor nitroprusside

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Amino acid analysis by reverse-phase high-performance liquid chromatography: Precolumn derivatization with phenylisothiocyanate

1984 • 1,616 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase

1987 • 896 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.

1990 • 573 citations

New Perspectives on the Microvasculature of the Islets of Langerhans in the Rat

1982 • 476 citations

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

1989 • 464 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanism

1990 • 362 citations

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells.

1982 • 349 citations

Inactivation of ribonucleotide reductase by nitric oxide

1991 • 331 citations

Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.

1989 • 320 citations

Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

1991 • 317 citations

Osteoclastic inhibition: an action of nitric oxide not mediated by cyclic GMP.

1991 • 307 citations

Determinants of the selective toxicity of alloxan to the pancreatic B cell.

1982 • 280 citations

Identification of N‐iminoethyl‐<scp>l</scp>‐ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells

1991 • 258 citations

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.

1991 • 257 citations

Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation

1991 • 257 citations

Evidence for Initial Involvement of Macrophage in Development of Insulitis in NOD Mice

1988 • 232 citations

Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase.

1988 • 218 citations

The order of islet microvascular cellular perfusion is B----A----D in the perfused rat pancreas.

1988 • 202 citations

Vascular smooth muscle-derived relaxing factor (MDRF) and its close similarity to nitric oxide

1990 • 183 citations

Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats

1989 • 183 citations

Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophages

1984 • 183 citations

Administration of Silica Prevents Diabetes in BB-Rats

1985 • 170 citations

Nitric oxide synthesis in the CNS, endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues

1991 • 166 citations

Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators

1989 • 166 citations

L-arginine-dependent reactive nitrogen intermediates as mediators of tumor cell killing by activated macrophages.

1990 • 155 citations

Low-Dose Streptozocin-Induced Diabetes in Mice: Electron Microscopy Reveals Single-Cell Insulitis Before Diabetes Onset

1988 • 151 citations

Inhibition of nitric oxide generation affects the induction of diabetes by streptozocin in mice

1991 • 148 citations

Haem-dependent activation of cytosolic guanylate cyclase by nitric oxide: a widespread signal transduction mechanism

1992 • 140 citations

L-Arginine Stimulates Cyclic Guanosine 3′,5′- Monophosphate Formation in Rat Islets of Langerhans and RINm5F Insulinoma Cells: Evidence for LArgininerNitric Oxide Synthase*

1991 • 122 citations

Preferential Infiltration of Macrophages During Early Stages of Insulitis in Diabetes-Prone BB Rats

1988 • 118 citations

Spontaneous cytotoxicity of macrophages against pancreatic islet cells.

1989 • 115 citations

Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor

1991 • 91 citations

Interleukin-1β induces nitric oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets

1992 • 91 citations

Macrophage cytotoxicity towards isolated rat islet cells: neither lysis nor its protection by nicotinamide are Beta-cell specific

1991 • 52 citations

Evidence for Guanosine 3’,5’-Monophosphate as a Putative Mediator of Insulin Secretion from Isolated Rat Islets*

1981 • 40 citations

Nitroprusside, antihypertensive drug and analytical reagent

1984 • 31 citations

Specific cation effect in the reaction of nitroprusside with cysteine, acetophenone and sulfite (Legal and boedeker reaction)

1984 • 18 citations

The differential functional stability of various forms of bovine liver rhodanese

1988 • 15 citations

Nitrovasodilators Have Proliferative as Well as Antiproliferative Effects

1991 • 12 citations