Expression and Deletion Mutagenesis of Tryptophan Hydroxylase Fusion Proteins: Delineation of the Enzyme Catalytic Core

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin.

1967 • 418 citations

Review of the role of the central serotonergic neuronal system in blood pressure regulation.

1980 • 249 citations

Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase.

1986 • 243 citations

Tryptophan hydroxylase. The role of oxygen, iron, and sulfhydryl groups as determinants of stability and catalytic activity.

1980 • 117 citations

Recombinant human tyrosine hydroxylase isozymes

1991 • 106 citations

Demonstration of the Phosphorylation-Dependent Interaction of Tryptophan Hydroxylase with the 14-3-3 Protein

1993 • 103 citations

Identification of the Site of Interaction of the 14-3-3 Protein with Phosphorylated Tryptophan Hydroxylase

1995 • 93 citations

Mechanism of oxygen activation by tyrosine hydroxylase

1987 • 83 citations

Formal Demonstration of the Phosphorylation of Rat Brain Tryptophan Hydroxylase by Ca²⁺/Calmodulin‐Dependent Protein Kinase

1989 • 78 citations

Tryptophan 5‐hydroxylase

1985 • 77 citations

Activation of brain tryptophan hydroxylase by ATP-MG2+: dependence on calmodulin.

1980 • 74 citations

Purification and Properties of Tryptophan 5‐Monooxygenase from Rat Brain‐Stem

1982 • 71 citations

Expression and characterization of catalytic and regulatory domains of rat tyrosine hydroxylase

1993 • 64 citations

Phosphorylation of recombinant human phenylalanine hydroxylase: effect on catalytic activity, substrate activation and protection against non-specific cleavage of the fusion protein by restriction protease

1996 • 60 citations

Amino Acid Control of Neurotransmitter Synthesis and Release: Physiological and Clinical Implications

1993 • 54 citations

Tryptophan Hydroxylase Is Phosphorylated by Protein Kinase A

1995 • 54 citations

Delineation of the catalytic core of phenylalanine hydroxylase and identification of glutamate 286 as a critical residue for pterin function.

1994 • 51 citations

Regulation of tryptophan hydroxylase activity by a cyclic AMP-dependent mechanism in rat striatum

1987 • 43 citations

Expression of rat liver phenylalanine hydroxylase in insect cells and site-directed mutagenesis of putative non-heme iron-binding sites.

1993 • 41 citations

d-fenfluramine and d-norfenfluramine hypophagias do not require increased hypothalamic 5-hydroxytryptamine release

1994 • 38 citations

Identification of the Intersubunit Binding Region in Rat Tyrosine Hydroxylase

1993 • 38 citations

Regulation of rat liver phenylalanine hydroxylase. I. Kinetic properties of the enzyme's iron and enzyme reduction site.

1994 • 36 citations

Deletion mutagenesis of rat PC12 tyrosine hydroxylase regulatory and catalytic domains

1993 • 24 citations

Simple and Rapid Purification of Tryptophan 5-Monooxygenase from Rabbit Brain by Affinity Chromatography1

1981 • 23 citations

Rapid polymerase chain reaction based analysis of DNA fragments cloned in lacZ vectors.

1990 • 4 citations