Stress-induced decrease in TRAF2 stability is mediated by Siah2

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

2000 • 1,302 citations

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1999 • 1,267 citations

RING Finger Proteins

2000 • 1,216 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

ASK1 Is Essential for JNK/SAPK Activation by TRAF2

1998 • 641 citations

Tumor necrosis factor receptor-associated factors (TRAFs)—a family of adapter proteins that regulates life and death

1998 • 597 citations

Siah-1, SIP, and Ebi Collaborate in a Novel Pathway for β-Catenin Degradation Linked to p53 Responses

2001 • 586 citations

Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.

1991 • 576 citations

The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27

2001 • 467 citations

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

1999 • 459 citations

Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

1997 • 454 citations

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

2002 • 453 citations

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

2000 • 429 citations

Siah-1 Mediates a Novel β-Catenin Degradation Pathway Linking p53 to the Adenomatous Polyposis Coli Protein

2001 • 416 citations

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

1996 • 415 citations

Structural basis for self-association and receptor recognition of human TRAF2

1999 • 355 citations

The TNF-receptor-associated factor family

2001 • 344 citations

4-1BB and Ox40 Are Members of a Tumor Necrosis Factor (TNF)-Nerve Growth Factor Receptor Subfamily That Bind TNF Receptor-Associated Factors and Activate Nuclear Factor κB

1998 • 342 citations

JNK targets p53 ubiquitination and degradation in nonstressed cells

1998 • 339 citations

Siah-1 N-Terminal RING Domain Is Required for Proteolysis Function, and C-Terminal Sequences Regulate Oligomerization and Binding to Target Proteins

1999 • 234 citations

PHYL Acts to Down-Regulate TTK88, a Transcriptional Repressor of Neuronal Cell Fates, by a SINA-Dependent Mechanism

1997 • 233 citations

Proteasomal regulation of nuclear receptor corepressor-mediated repression

1998 • 225 citations

CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival

1997 • 224 citations

p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1

1998 • 203 citations

Mammalian homologs of seven in absentia regulate DCC via the ubiquitin–proteasome pathway

1997 • 189 citations

Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling

2001 • 182 citations

Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis

2000 • 168 citations

Differential Signaling and Tumor Necrosis Factor Receptor–Associated Factor (Traf) Degradation Mediated by Cd40 and the Epstein-Barr Virus Oncoprotein Latent Membrane Protein 1 (Lmp1)

2001 • 158 citations

Peg3/Pw1 is an imprinted gene involved in the TNF-NFκB signal transduction pathway

1998 • 148 citations

TNFR-Associated Factor Family Protein Expression in Normal Tissues and Lymphoid Malignancies

2000 • 143 citations

Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina)

1993 • 135 citations

Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-α signaling

2001 • 134 citations

TRAF2 Deficiency Results in Hyperactivity of Certain TNFR1 Signals and Impairment of CD40-Mediated Responses

1999 • 133 citations

SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: Identification of common effectors with p53 and p21 ^Waf1

1999 • 114 citations

Activation of Stress-activated Protein Kinase/c-Jun N-terminal Kinase, but Not NF-κB, by the Tumor Necrosis Factor (TNF) Receptor 1 through a TNF Receptor-associated Factor 2- and Germinal Center Kinase Related-dependent Pathway

1997 • 110 citations

SIAH-1 interacts with α-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis

2000 • 84 citations

Regulation of BOB.1/OBF.1 stability by SIAH

2001 • 73 citations

The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1

2001 • 72 citations

hSiah2 Is a New Vav Binding Protein Which Inhibits Vav-Mediated Signaling Pathways

1999 • 42 citations

Alteration of the stability of Bag-1 protein in the control of olfactory neuronal apoptosis

2001 • 41 citations

Expression of ring finger-deleted TRAF2 sensitizes metastatic melanoma cells to apoptosis via up-regulation of p38, TNFα and suppression of NF-κB activities

2001 • 41 citations

Expression of the tumour necrosis factor receptor-associated factors 1 and 2 in Hodgkin's disease

2001 • 36 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 13 citations