Residues in the Membrane-spanning and Extracellular Loop Regions of the Parathyroid Hormone (PTH)-2 Receptor Determine Signaling Selectivity for PTH and PTH-related Peptide

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

1996 • 1,952 citations

PTH/PTHrP Receptor in Early Development and Indian Hedgehog—Regulated Bone Growth

1996 • 1,303 citations

A Parathyroid Hormone-Related Protein Implicated in Malignant Hypercalcemia: Cloning and Expression

1987 • 1,293 citations

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

1992 • 1,009 citations

Projection structure of rhodopsin

1993 • 758 citations

Transmembrane helices predicted at 95% accuracy

1995 • 669 citations

Identification and Functional Expression of a Receptor Selectively Recognizing Parathyroid Hormone, the PTH2 Receptor

1995 • 414 citations

Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family

1993 • 291 citations

Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor.

1993 • 193 citations

Full Activation of Chimeric Receptors by Hybrids between Parathyroid Hormone and Calcitonin

1996 • 170 citations

Critical Contributions of Amino-terminal Extracellular Domains in Agonist Binding and Activation of Secretin and Vasoactive Intestinal Polypeptide Receptors. STUDIES OF CHIMERIC RECEPTORS

1995 • 169 citations

Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney.

1988 • 153 citations

The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34).

1994 • 145 citations

Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat.

1996 • 115 citations

Role of the extracellular regions of the parathyroid hormone (PTH)/PTH-related peptide receptor in hormone binding.

1994 • 113 citations

Converting Parathyroid Hormone-related Peptide (PTHrP) into a Potent PTH-2 Receptor Agonist

1996 • 99 citations

The Bovine Renal Parathyroid Hormone (PTH) Receptor Has Equal Affinity for Two Different Amino Acid Sequences: The Receptor Binding Domains of PTH and PTH-Related Protein Are Located within the 14–34 Region

1990 • 97 citations

Chimeric Human Calcitonin and Glucagon Receptors Reveal Two Dissociable Calcitonin Interaction Sites

1995 • 95 citations

Transmembrane Residues of the Parathyroid Hormone (PTH)/PTH-related Peptide Receptor That Specifically Affect Binding and Signaling by Agonist Ligands

1996 • 92 citations

Determinants of [Arg2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor.

1994 • 90 citations

Non-Homologous Sequences of Parathyroid Hormone and the Parathyroid Hormone Related Peptide Bind to a CommonReceptor on ROS 17/2.8 Cells

1989 • 81 citations

Direct mapping of an agonist-binding domain within the parathyroid hormone/parathyroid hormone-related protein receptor by photoaffinity crosslinking

1997 • 81 citations

Homolog-scanning mutagenesis of the parathyroid hormone (PTH) receptor reveals PTH-(1-34) binding determinants in the third extracellular loop.

1995 • 79 citations

Molecular Mechanism of Action of Non-peptide Ligands for Peptide Receptors

1995 • 78 citations

The Amino-Terminal Fragment of the Adenylate-Cyclase Activating Polypeptide (Pacap) Receptor Functions as a High-Affinity Pacap Finding Domain

1995 • 70 citations

Evidence for a Parathyroid Hormone-2 Receptor Selective Ligand in the Hypothalamus

1997 • 68 citations

Histidine at position 5 is the specificity "switch" between two parathyroid hormone receptor subtypes.

1996 • 58 citations

Parathyroid hormone receptors are plasma membrane glycoproteins with asparagine-linked oligosaccharides.

1988 • 51 citations

A Putative Selectivity Filter in the G-protein-coupled Receptors for Parathyroid Hormone and Secretin

1996 • 50 citations

Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor.

1996 • 46 citations

Deletions of Portions of the Extracellular Loops of the Lutropin/Choriogonadotropin Receptor Decrease the Binding Affinity for Ovine Luteinizing Hormone, but Not Human Choriogonadotropin, by Preventing the Formation of Mature Cell Surface Receptor

1996 • 26 citations