Mechanisms of acetaminophen oxidation to N-acetyl-P-benzoquinone imine by horseradish peroxidase and cytochrome P-450.

DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

1949 • 16,078 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

1973 • 1,717 citations

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

1984 • 1,050 citations

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

1982 • 1,021 citations

PLASMA-PARACETAMOL HALF-LIFE AND HEPATIC NECROSIS IN PATIENTS WITH PARACETAMOL OVERDOSAGE

1971 • 610 citations

Acute liver necrosis following overdose of paracetamol.

1966 • 525 citations

Identification, by Electron Paramagnetic Resonance Spectroscopy, of Free Radicals Generated from Substrates by Peroxidase

1960 • 343 citations

Studies on hydroperoxide-dependent substrate hydroxylation by purified liver microsomal cytochrome P-450

1976 • 339 citations

Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes

1975 • 330 citations

Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity.

1985 • 310 citations

Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen

1974 • 290 citations

The kinetics and stoichiometry of the transition from the primary to the secondary peroxidase peroxide complexes

1952 • 281 citations

Hydroperoxide‐Metabolizing Systems in Rat Liver

1975 • 266 citations

HEPATIC DAMAGE AND DEATH FROM OVERDOSE OF PARACETAMOL

1973 • 244 citations

Microsomal-catalyzed hydroperoxide-dependent C-oxidation of amines

1973 • 193 citations

Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450

1974 • 173 citations

The spectra of the enzyme-substrate complexes of catalase and peroxidase

1952 • 163 citations

[143] Plant peroxidase

1955 • 159 citations

Chemical Nature of the Secondary Hydrogen Peroxide Compound Formed by Cytochrome-C Peroxidase and Horseradish Peroxidase

1952 • 153 citations

Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen

1983 • 146 citations

Acetaminophen hepatotoxicity

1983 • 96 citations

Acetaminophen: enzymatic formation of a transient phenoxyl free radical

1984 • 91 citations

3-(glutathion-S-yl)acetaminophen: a biliary metabolite of acetaminophen.

1982 • 89 citations

Superoxide and hydrogen peroxide production and NADPH oxidation stimulated by nitrofurantoin in lung microsomes: Possible implications for toxicity

1979 • 85 citations

Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilete: Oxygenation or electron transfer?

1981 • 82 citations

Reactions of N-acetyl-p-benzoquinone imine with reduced glutathione, acetaminophen, and NADPH.

1986 • 82 citations

Identification of acetaminophen polymerization products catalyzed by horseradish peroxidase.

1985 • 80 citations

Differences in the mechanism of NADPH- and cumene hydroperoxide-supported reactions of cytochrome P-450

1980 • 75 citations

3-Hydroxyacetaminophen: a microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen.

1980 • 65 citations

The formation and toxicity of catechol metabolites of acetaminophen in mice.

1984 • 40 citations

Horseradish peroxidase-catalyzed oxidation of acetaminophen to intermediates that form polymers or conjugate with glutathione.

1986 • 39 citations

Enzymatic and non-enzymatic reduction of N-acetyl-p-benzoquinone imine and some properties of the N-acetyl-p-benzosemiquinone imine radical

1984 • 32 citations

Stable free radical and benzoquinone imine metabolites of an acetaminophen analogue.

1984 • 31 citations