Evidence for functional dissociation of dependence and tolerance in guinea‐pig isolated ileal segments following 20 hour exposure to morphine in vitro

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

Enzyme changes in neonatal skeletal muscle: effect of thyroid deficiency

1978 • 1,103 citations

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.

1989 • 519 citations

Cellular site of opiate dependence

1980 • 201 citations

Mechanisms of cellular adaptive sensitivity changes: applications to opioid tolerance and dependence.

1989 • 176 citations

MODEL OF OPIATE DEPENDENCE IN THE GUINEA‐PIG ISOLATED ILEUM

1981 • 84 citations

Antagonist-induced opioid receptor up-regulation. I. Characterization of supersensitivity to selective mu and kappa agonists.

1988 • 79 citations

Withdrawal responses of guinea-pig isolated ileum following brief exposure to opiates and opioid peptides

1986 • 49 citations

PHARMACOLOGICAL CHARACTERIZATION OF OPIATE PHYSICAL DEPENDENCE IN THE ISOLATED ILEUM OF THE GUINEA‐PIG

1981 • 44 citations

Naloxone-induced depolarization and synaptic activation of myenteric neurons in morphine-dependent guinea pig ileum

1987 • 25 citations

Morphine tolerance and nonspecific subsensitivity of the longitudinal muscle myenteric plexus preparation of the guinea-pig to inhibitory agonists

1988 • 25 citations

Effect of ?2-adrenoceptor agonists on the expression of morphine-withdrawal in rats

1992 • 23 citations

Opioid dependence in the guinea-pig myenteric plexus is controlled by non-tolerant and tolerant opioid receptors

1985 • 21 citations

Effect of clonidine, nimodipine and diltiazem on the in vitro opioid withdrawal response in the guinea‐pig ileum

1990 • 20 citations

Circannual variation in sensitivity of the guinea-pig isolated ileum to naloxone

1980 • 13 citations

Inability of an opioid antagonist lacking negative intrinsic activity to induce opioid receptor up‐regulation in vivo

1991 • 12 citations

Effects of putative neurotransmitters and related drugs on withdrawal contractures of guinea‐pig isolated ileum following brief contact with [Met⁵] enkephalin

1990 • 10 citations