PHARMACOLOGICAL CHARACTERIZATION OF OPIATE PHYSICAL DEPENDENCE IN THE ISOLATED ILEUM OF THE GUINEA‐PIG

A METHOD FOR JUDGING ALL CONTRASTS IN THE ANALYSIS OF VARIANCE^*

1953 • 1,732 citations

Opiates and endogenous opioid peptides

1977 • 1,282 citations

A Method for Judging all Contrasts in the Analysis of Variance

1953 • 830 citations

Simultaneous quantitative assessment of morphine tolerance and physical dependence.

1969 • 681 citations

THE ACTION OF MORPHINE AND RELATED SUBSTANCES ON CONTRACTION AND ON ACETYLCHOLINE OUTPUT OF COAXIALLY STIMULATED GUINEA-PIG ILEUM

1957 • 636 citations

THE ACTION OF MORPHINE AND RELATED SUBSTANCES ON CONTRACTION AND ON ACETYLCHOLINE OUTPUT OF COAXIALLY STIMULATED GUINEA‐PIG ILEUM

1997 • 632 citations

In Vitro Models in the Study of Structure-Activity Relationships of Narcotic Analgesics

1975 • 289 citations

The human pharmacology and abuse potential of N-allylnoroxymorphone (naloxone).

1967 • 278 citations

Current Developments in Psychopharmacology

1978 • 242 citations

Physical Dependence of Opiate-Like Peptides

1976 • 219 citations

The Principles of Biological Assay

1947 • 213 citations

Receptor binding and pharmacological activity of opiates in the guinea-pig intestine.

1975 • 182 citations

Morphine‐tolerant longitudinal muscle strip from guinea‐pig ileum

1973 • 155 citations

Narcotic-antagonist analgesics: interactions with cholinergic systems.

1969 • 125 citations

Drug addiction : experimental pharmacology

1972 • 124 citations

THE EFFECT OF ANALGESIC DRUGS ON THE RELEASE OF ACETYLCHOLINE FROM ELECTRICALLY STIMULATED GUINEA‐PIG ILEUM

1966 • 120 citations

Effects of short- and long-term administration of pentazocine in man

1970 • 118 citations

Properties of the enteric nervous system: Limitation of access of intravascular macromolecules to the myenteric plexus and muscularis externa

1978 • 112 citations

Mechanisms of Pain and Analgesic Compounds

1980 • 112 citations

AGONIST AND ANTAGONIST ACTIONS OF MORPHINELIKE DRUGS ON THE GUINEA‐PIG ISOLATED ILEUM

1966 • 109 citations

OPIATE ADDICTION IN THE MONKEY I. METHODS OF STUDY

1936 • 86 citations

Electrically stimulated release of opiate-like material from the myenteric plexus of the guinea pig ileum

1977 • 84 citations

Opioid antagonists.

1967 • 81 citations

Demonstration of tolerance to and physical dependence of N-allylnormorphine (nalorphine).

1965 • 73 citations

Inhibition by naloxone of tolerance and dependence in mice treated acutely and chronically with morphine.

1977 • 66 citations

Administration of pellets of morphine to mice; abstinence syndrome.

1961 • 59 citations

Tolerance and dependence induced by morphine-like pituitary peptides in rats

1976 • 55 citations

Correlation between the in vivo and an in vitro expression of opiate withdrawal precipitated by naloxone: their antagonism by l-(-)-delta9-tetrahydrocannabinol.

1976 • 48 citations

ANTINOCICEPTIVE ACTIVITY OF THE NARCOTIC ANTAGONIST ANALGESICS AND ANTAGONISTIC ACTIVTY OF NARCOTIC ANALGESICS IN RODENTS

1971 • 47 citations

THE EFFECT OF AMITRIPTYLINE ON PRESYNAPTIC MECHANISMS IN NORADRENERGIC NERVES

1978 • 39 citations

The effects of naltrexone on the development of physical dependence on morphine

1978 • 39 citations

Opiate withdrawal signs in single myenteric neurones

1978 • 30 citations

Tests for addiction (chronic intoxication) of morphine type.

1963 • 27 citations

Physiological Pharmacology. A Comprehensive Treatise

1964 • 22 citations

Dependence liability of enkephalin in the myenteric plexus of the guinea pig

1976 • 21 citations

THE ROLE OF SUPERSENSITIVITY TO ACETYLCHOLINE IN THE PRODUCTION OF TOLERANCE TO MORPHINE IN STIMULATED GUINEA‐PIG ILEUM

1974 • 20 citations

Precipitated morphine withdrawal in rats as a tool in opiate research.

1977 • 15 citations

Morphine dependence in the isolated guinea-pig ileum and its modification by p-chlorophenylalanine

1978 • 15 citations

Failure of an opiate to protect mice against naloxone-precipitated withdrawal.

1972 • 14 citations

Circannual variation in sensitivity of the guinea-pig isolated ileum to naloxone

1980 • 13 citations

Quantification of the in vitro induced tolerance to morphine of the isolated guinea pig ileum

1978 • 10 citations

Electrically induced narcotic-like dependence in the isolated guinea-pig ileum

1980 • 5 citations