Cleavage of membrane-associated ICAM-1 from astrocytes: Involvement of a metalloprotease

Adhesion receptors of the immune system

1990 • 6,585 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

Leukocyte-endothelial adhesion molecules

1994 • 1,884 citations

Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence

1972 • 1,456 citations

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.

1986 • 1,428 citations

An enzymic method for the trace iodination of immunoglobulins and other proteins

1969 • 1,414 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families

1988 • 967 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

Intercellular adhesion molecule-1

1996 • 788 citations

A form of circulating ICAM-1 in human serum.

1991 • 700 citations

Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells

1992 • 653 citations

Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action

1992 • 614 citations

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

1994 • 571 citations

Cytokine regulation of metalloproteinase gene expression

1993 • 432 citations

Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system.

1990 • 388 citations

Degradation of Interleukin 1β by Matrix Metalloproteinases

1996 • 374 citations

The function of human intercellular adhesion molecule‐1 (ICAM‐1) in the generation of an immune response

1988 • 351 citations

A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection

1990 • 292 citations

Shedding of ICAM-1 from human melanoma cell lines induced by IFN-gamma and tumor necrosis factor-alpha. Functional consequences on cell-mediated cytotoxicity.

1991 • 281 citations

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor.

1995 • 254 citations

Inhibition of Angiogenesis and Murine Hemangioma Growth by Batimastat, a Synthetic Inhibitor of Matrix Metalloproteinases

1995 • 234 citations

A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes.

1995 • 234 citations

The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation.

1996 • 230 citations

The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-λ, tumor necrosis factor α, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation

1989 • 227 citations

Matrix metalloproteinases and processing of pro-TNF-α

1995 • 222 citations

Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse.

1994 • 216 citations

Effect of Matrix Metalloproteinase Inhibitor Batimastat on Breast Cancer Regrowth and Metastasis in Athymic Mice

1995 • 190 citations

A THERMOLYSIN INHIBITOR PRODUCED BY ACTINOMYCETES: PHOSPHORAMIDON

1973 • 185 citations

Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-α and blood-brain barrier damage

1993 • 180 citations

Serum levels of circulating intercellular adhesion molecule 1 in human malignant melanoma.

1991 • 173 citations

Metalloprotease and serine protease are involved in cleavage of CD43, CD44, and CD16 from stimulated human granulocytes. Induction of cleavage of L-selectin via CD16.

1994 • 160 citations

Soluble P‐selectin is present in normal circulation and its plasma level is elevated in patients with thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome

1993 • 151 citations

Distribution of Immunoglobulin Superfamily Members ICAM-1, -2, -3, and the β2 Integrin LFA-1 in Multiple Sclerosis Lesions

1996 • 146 citations

Novel isoforms of murine intercellular adhesion molecule-1 generated by alternative RNA splicing.

1995 • 146 citations

Soluble intercellular adhesion molecule-1 inhibits MHC-restricted specific T cell/tumor interaction.

1993 • 143 citations

Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines.

1995 • 140 citations

Circulating ICAM-1 is increased in septic shock.

1995 • 135 citations

Purification and characterization of a phosphoramidon-sensitive endothelin-converting enzyme in porcine aortic endothelium. OFF.

1993 • 134 citations

Intercellular adhesion molecule-1 gene expression by glial cells. Differential mechanisms of inhibition by IL-10 and IL-6.

1995 • 134 citations

Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-α, interleukin-1β, and interferon-γ in astrocytes

1994 • 129 citations

Adhesion-related molecules in the central nervous system. Upregulation correlates with inflammatory cell influx during relapsing experimental autoimmune encephalomyelitis.

1991 • 128 citations

Soluble forms of intercellular adhesion molecule-1 (ICAM-1) block lymphocyte attachment to cerebral endothelial cells

1995 • 128 citations

Circulating, soluble adhesion proteins in cerebrospinal fluid and serum of patients with multiple sclerosis: Correlation with clinical activity

1995 • 111 citations

Involvement of a metalloprotease in spontaneous and phorbol ester-induced release of natural killer cell-associated Fc gamma RIII (CD16-II).

1991 • 108 citations

Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease.

1994 • 104 citations

Soluble intercellular adhesion molecule 1 is released by human melanoma cells and is associated with tumor growth in nude mice.

1992 • 102 citations

Tumor necrosis factor alpha induces adhesion molecule expression on human fetal astrocytes.

1992 • 98 citations

Induction and regulation of class II major histocompatibility complex mRNA expression in astrocytes by interferon-γ and tumor necrosis factor-α

1990 • 91 citations

Serial analysis of circulating adhesion molecules and TNF receptor in serum from patients a with multinle sclerosis

1994 • 88 citations

Sequence and expression of rat ICAM-1

1992 • 87 citations

Expression of ICAM-1, VCAM-1, L-selectin, and leukosialin in the mouse central nervous system during the induction and remission stages of experimental allergic encephalomyelitis

1994 • 83 citations

CNS antigen presentation

1995 • 82 citations

Soluble IL-2 receptor levels in serum from blood donors seropositive for HIV.

1988 • 79 citations

Expression of VCAM-1 (CD106) by a subset of TCR gamma delta-bearing lymphocyte clones. Involvement of a metalloprotease in the specific hydrolytic release of the soluble isoform.

1995 • 68 citations

Stimulus-specific inhibition of intracellular adhesion molecule-1 gene expression by TGF-beta.

1996 • 63 citations

Interferon-gamma-induced astrocyte class II major histocompatibility complex gene expression is associated with both protein kinase C activation and Na+ entry.

1991 • 61 citations

Inhibition of Molt-4-endothelial adherence by synthetic peptides from the sequence of ICAM-1.

1992 • 46 citations

Soluble intercellular adhesion molecule-1 in serum and cerebrospinal fluid of clinically active relapsing-remitting multiple sclerosis

1996 • 43 citations

sICAM-1 Enhances Cytokine Production Stimulated by Alloantigen

1993 • 34 citations

Characterization of a membrane-bound metalloendoprotease of rat C6 glioblastoma cells.

1994 • 32 citations

Differential expression and release of cd54 induced by cytokines*1

1995 • 28 citations

Expression of Intercellular Adhesion Molecule-1 and Lymphocyte Function-Associated Antigen-1 in the Spinal Cord of Rats During Acute Experimental Allergic Encephalomyelitis

1994 • 16 citations

Soluble forms of CD44 and CD54 (ICAM-1) cellular adhesion molecules are released by human prostatic cancer cell lines

1996 • 15 citations

Phorbol ester-induced shedding of intercellular adhesion molecule-1 (ICAM-1) on erythroleukemic K 562 cells

1996 • 4 citations