Why Do So Many Cancer Patients Fail to Respond to Interferon Therapy?

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Angiogenesis.

1992 • 2,581 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients

1990 • 1,544 citations

Cytokine therapeutics: lessons from interferonalpha.

1994 • 703 citations

Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia

1978 • 593 citations

Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.

1995 • 574 citations

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

1994 • 490 citations

Treatment of Pulmonary Hemangiomatosis with Recombinant Interferon Alfa-2a

1989 • 444 citations

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

1993 • 436 citations

Quantitative studies on viral interference in suspended L cells

1962 • 395 citations

Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated

1990 • 377 citations

Mechanism of the Antitumour Effect of Interferon in Mice

1972 • 317 citations

ANTI-RETROVIRAL EFFECTS OF INTERFERON-α IN AIDS-ASSOCIATED KAPOSI'S SARCOMA

1988 • 261 citations

Resistance to Recombinant Interferon Alfa-2a in Hairy-Cell Leukemia Associated with Neutralizing Anti-Interferon Antibodies

1988 • 251 citations

Stromal Involvement In Malignant Growth

1988 • 225 citations

Enhanced expression of β ₂ -microglobulin and HLA antigens on human lymphoid cells by interferon

1978 • 215 citations

Neutralizing Antibodies to Interferon- : Relative Frequency in Patients Treated with Different Interferon Preparations

1991 • 214 citations

Enhancement by Interferon of the Expression of Surface Antigens on Murine Leukemia L 1210 Cells

1973 • 204 citations

Microvascular Injury in Pathogenesis of Interferon-Induced Necrosis of Subcutaneous Tumors in Mice

1989 • 192 citations

Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription.

1993 • 189 citations

Interferon alpha-2b as therapy for Ph'-positive chronic myelogenous leukemia: a study of 82 patients treated with intermittent or daily administration

1988 • 184 citations

Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNA.

1991 • 163 citations

Appearance of interferon inducibility and sensitivity during differentiation of murine teratocarcinoma cells in vitro

1978 • 154 citations

An Update of the Medical Treatment of Malignant Endocrine Pancreatic Tumors

1993 • 142 citations

A randomized study of low and high doses of leukocyte alpha-interferon in metastatic renal cell carcinoma: the American Cancer Society collaborative trial.

1985 • 139 citations

Interferon and Cell Division. IX. Interferon-Resistant L1210 Cells: Characteristics and Origin2

1974 • 132 citations

JAK protein tyrosine kinases: their role in cytokine signalling

1994 • 125 citations

Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products

1988 • 124 citations

Human leukocyte interferon subtypes have different antiproliferative and antiviral activities on human cells

1983 • 119 citations

How Cells Cycle Toward Cancer

1994 • 117 citations

He's Not Going to Talk About In Vitro Predictive Assays Again, Is He?

1990 • 115 citations

Interferon-activated signal transduction to the nucleus

1994 • 108 citations

Inhibitory effects of interferon on the expression of genes regulated by platelet-derived growth factor.

1985 • 97 citations

Is Interferon Tissue Specific? -- Effect of Human Leukocyte and Fibroblast Interferons on the Growth of Lymphoblastoid and Osteosarcoma Cell Lines

1977 • 92 citations

Chronic B-lymphocytic leukemia cells proliferate and differentiate following exposure to interferon in vitro

1986 • 90 citations

Cytokine triggered molecular pathways that control cell cycle arrest

1992 • 89 citations

Cells resistant to interferon are defective in activation of a promoter-binding factor.

1988 • 83 citations

Apoptosis in Burkitt lymphoma cells is driven by c-myc.

1993 • 77 citations

The EBNA2-related resistance towards alpha interferon (IFN-alpha) in Burkitt's lymphoma cells effects induction of IFN-induced genes but not the activation of transcription factor ISGF-3.

1992 • 73 citations

Interferon-gamma induction of LFA-1-mediated homotypic adhesion of human monocytes.

1986 • 72 citations

Circulating Human Interferon after Intramuscular Injection into Animals and Man

1974 • 70 citations

In Vivo Sensitivity and Resistance of Chronic Myelogenous Leukemia Cells to a-Interferon: Correlation with Receptor Binding and Induction of 2, 5-Oligoadenylate Synthetase

1986 • 68 citations

Interferons and interleukin-6 suppress the DNA-binding activity of E2F in growth-sensitive hematopoietic cells.

1993 • 68 citations

Interferon-induced enhancement of 2',5'-oligoadenylate synthetase in mid-gut carcinoid tumours

1990 • 66 citations

Effective natural interferon-alpha therapy in recombinant interferon- alpha-resistant patients with hairy cell leukemia

1991 • 63 citations

Interferon and natural killer activity in multiple myeloma. Lack of correlation between interferon‐induced enhancement of natural killer activity and clinical response to human interferon‐α

1982 • 63 citations

Correlation between in vitro and in vivo sensitivity to human leucocyte interferon in patients with multiple myeloma

1985 • 61 citations

Effective natural interferon-alpha therapy in recombinant interferon- alpha-resistant patients with hairy cell leukemia

1991 • 58 citations

Cytolytic activity of interferon‐gamma and its synergism with 5‐fluorouracil

1984 • 57 citations

Treatment of anti‐recombinant interferon‐alpha 2 antibody positive CML patients with natural interferon‐alpha

1991 • 56 citations

Interferon treatment of human malignancies - a short review

1993 • 50 citations

High doses of natural α‐interferon (α‐IFN) in the treatment of multiple myeloma — A pilot study from the Myeloma Group of Central Sweden (MGCS)

1988 • 48 citations

Clinical and laboratory changes induced by alpha interferon in chronic lymphocytic leukemia‐a pilot study

1987 • 45 citations

Response to interferon therapy in patients with multiple myeloma correlates with expression of the Bcl‐2 oncoprotein

1995 • 40 citations

Primary leukemia cells resistant to alpha-interferon in vitro are defective in the activation of the DNA-binding factor interferon- stimulated gene factor 3

1994 • 39 citations

Isolation of Daudi Cells with Reduced Sensitivity to Interferon.: I. Characterization

1983 • 39 citations

Treatment of neuroendocrine tumors

1994 • 35 citations

Interferon-γ (IFN-γ) Induces Programmed Cell Death in Differentiated Human Leukemic B Cell Lines

1994 • 35 citations

Cytotoxic effect of interferon on primary malignant tumour cells. Studies in various malignancies

1993 • 34 citations

Nomenclature of the Human Interferon Genes^a

1993 • 27 citations

Interaction of IFN α/β with host cells essential to the early inhibition of friend erythroleukemia visceral metastases in mice

1994 • 25 citations

Interferon system defects in malignant T-cells.

1994 • 22 citations

Human cancer cell lines express a negative transcriptional regulator of the interferon regulatory factor family of DNA binding proteins.

1994 • 20 citations

Treatment Options for Hairy Cell Leukemia

1997 • 20 citations

Inhibitory effects of alpha-interferon on epidermal growth factor-mediated receptor-dependent events.

1993 • 18 citations

Inhibition of mouse alpha/beta-interferon of the multiplication of alpha/beta-interferon-resistant Friend erythroleukemia cells cocultured with mouse hepatocytes.

1990 • 15 citations

Antibodies in patients with recurrent respiratory papillomatosis treated with lymphoblastoid interferon.

1991 • 13 citations

Interferon levels in human pulmonary tumors are lower than plasma levels.

1990 • 12 citations

Neutralising antibodies in patients with multiple myeloma receiving maintenance therapy with interferon α2b

1994 • 10 citations

In vivo and in vitro induction of 2'-5' oligoadenylate synthetase by interferon-alpha in nodular non-Hodgkin's lymphoma and correlations with the clinical response.

1990 • 9 citations

Induction of 2′,5′-oligoadenylate synthetase in freshly separated malignant cells from solid tumors. Variability in the susceptibility of interferon

1987 • 9 citations