Endotoxin Triggers Nuclear Factor-κB–dependent Up-regulation of Multiple Proinflammatory Genes in the Diaphragm

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Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

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The IKK NF-κB system: a treasure trove for drug development

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IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice

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Adhesion molecules and inflammatory injury

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NF-κB-Induced Loss of MyoD Messenger RNA: Possible Role in Muscle Decay and Cachexia

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Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

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EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units

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TNF‐α acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle

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Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression

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Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-κB activation in response to tumor necrosis factor α

1998 • 486 citations

Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor‐κΒ

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Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice.

1996 • 400 citations

Evidence that reactive oxygen species do not mediate NF- B activation

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Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival

2002 • 315 citations

Respiratory and Limb Muscle Weakness Induced by Tumor Necrosis Factor-α

2002 • 315 citations

Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle

2002 • 245 citations

Cytokines and chemokines are both expressed by human myoblasts: possible relevance for the immune pathogenesis of muscle inflammation.

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IKKα, IKKβ, and NEMO/IKKγ Are Each Required for the NF-κB-mediated Inflammatory Response Program

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Respiratory muscle fatigue: a cause of ventilatory failure in septic shock

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Production of Interleukin-6 by Skeletal Myotubes

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A variety of cytokines and immunologically relevant surface molecules are expressed by normal human skeletal muscle cells under proinflammatory stimuli

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Skeletal muscle satellite cell diversity: Satellite cells form fibers of different types in cell culture

1991 • 157 citations

Induction of diaphragmatic nitric oxide synthase after endotoxin administration in rats: role on diaphragmatic contractile dysfunction.

1996 • 140 citations

Mechanical Ventilation Protects against Diaphragm Injury in Sepsis

2002 • 129 citations

Temporal gene expression profiling of dystrophin-deficient (mdx) mouse diaphragm identifies conserved and muscle group-specific mechanisms in the pathogenesis of muscular dystrophy

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Constitutive and cytokine-induced production of interleukin-6 by human myoblasts

1994 • 101 citations

Diaphragm Sarcolemmal Injury Is Induced by Sepsis and Alleviated by Nitric Oxide Synthase Inhibition

1998 • 97 citations

Tumor necrosis factor alpha decreases in vivo diaphragm contractility in dogs.

1994 • 97 citations

Differential Cytokine Gene Expression in the Diaphragm in Response to Strenuous Resistive Breathing

2004 • 78 citations

TNF-alpha mRNA expression in diaphragm muscle after endotoxin administration.

1995 • 75 citations

CD14-independent activation of cardiomyocyte signal transduction by bacterial endotoxin

2000 • 69 citations

MECHANISM OF IL-1 INDUCED INHIBITION OF PROTEIN SYNTHESIS IN SKELETAL MUSCLE

1999 • 68 citations

Preferential Diaphragmatic Weakness during Sustained Pseudomonas aeruginosa Lung Infection

2003 • 63 citations

Sepsis increases contraction-related generation of reactive oxygen species in the diaphragm

1999 • 61 citations

Modulation of bone marrow-derived neutrophil signaling by H₂O₂: disparate effects on kinases, NF-κB, and cytokine expression

2004 • 54 citations

Expression of Nitric Oxide Synthases and GTP Cyclohydrolase I in the Ventilatory and Limb Muscles During Endotoxemia

1997 • 53 citations

Monocyte Inflammatory Mediators ImpairIn VitroHamster Diaphragm Contractility

1992 • 51 citations

Effects of N-Acetylcysteine on Diaphragmatic Function and Malondialdehyde Content inEscherichia coliEndotoxemic Rats

1992 • 44 citations

Lipopolysaccharide-induced Diaphragmatic Contractile Dysfunction and Sarcolemmal Injury in Mice Lacking the Neuronal Nitric Oxide Synthase

2001 • 42 citations

Expression and Regulation of CC Class Chemokines in the Dystrophic (mdx) Diaphragm

2005 • 41 citations

Analysis of Differential Lipofection Efficiency in Primary and Established Myoblasts

2002 • 36 citations

Expression of nitric oxide synthase isoforms in normal ventilatory and limb muscles

1997 • 34 citations

Lipopolysaccharide-induced Diaphragmatic Contractile Dysfunction in Mice Lacking the Inducible Nitric Oxide Synthase

1999 • 26 citations

Differential Induction of TNF- α and MnSOD by Endotoxin

2001 • 20 citations

Regulation of tumor necrosis factor-alpha production in the isolated rat heart stimulated by bacterial lipopolysaccharide or reactive oxygen.

2004 • 3 citations

Regulation of Tumor Necrosis Factor-α Production in the Isolated Rat Heart Stimulated by Bacterial Lipopolysaccharide or Reactive Oxygen

2004 • 3 citations