Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis

2003 • 796 citations

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

1998 • 643 citations

A Role for CD5 in TCR-Mediated Signal Transduction and Thymocyte Selection

1995 • 437 citations

Fine Tuning of TCR Signaling by CD5

2001 • 270 citations

Negative Selection during the Peripheral Immune Response to Antigen

2000 • 165 citations

Dynamic Tuning of T Cell Reactivity by Self-Peptide–Major Histocompatibility Complex Ligands

2001 • 114 citations

The thymus and central tolerance

2001 • 110 citations

A transgenic mouse model to analyze CD8⁺effector T cell differentiationin vivo

1999 • 97 citations

Lymphocyte populations and immune responses in CD5‐deficient mice

1994 • 96 citations

A Novel Bcl-x Isoform Connected to the T Cell Receptor Regulates Apoptosis in T Cells

1997 • 95 citations

Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection.

1995 • 84 citations

Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells

1999 • 38 citations

The influence of the thymic environment on the CD4-versus-CD8 T lineage decision

2003 • 36 citations

Positive Selection as a Developmental Progression Initiated by αβTCR Signals that Fix TCR Specificity prior to Lineage Commitment

1999 • 30 citations

T Cell Costimulation through CD28 Depends on Induction of the Bcl-xγ Isoform

2002 • 15 citations