Aging, Alcohol, and the Liver

Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.

1973 • 1,467 citations

Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.

1973 • 1,174 citations

The Effect of Age on Creatinine Clearance in Men: A Cross-sectional and Longitudinal Study

1976 • 1,111 citations

Hepatic Microsomal Ethanol-oxidizing System

1970 • 824 citations

Drug Disposition in Old Age

1982 • 589 citations

Ethanol Oxidation by Hepatic Microsomes: Adaptive Increase after Ethanol Feeding

1968 • 562 citations

Medical Disorders of Alcoholism

1995 • 515 citations

Acetaminophen Hepatotoxicity in Alcoholics

1986 • 421 citations

Aging and ethanol metabolism

1977 • 362 citations

Diazepam disposition determinants

1980 • 348 citations

Antipyrine metabolism in man: Influence of age, alcohol, caffeine, and smoking

1975 • 320 citations

Age as a determinant of sensitivity to warfarin.

1977 • 263 citations

Glutathione depletion and susceptibility.

1984 • 249 citations

Kinetics of intravenous and intramuscular morphine

1978 • 236 citations

Learning and Memory Impairments in Young and Old Alcoholics: Evidence for the Premature‐Aging Hypothesis

1980 • 221 citations

Inhibition of drug metabolism by acute ethanol intoxication

1970 • 211 citations

Increased Rate of Clearance of Drugs from the Circulation of Alcoholics*

1969 • 209 citations

Reduced Serum Albumin Concentration in the Elderly: A Report from the Boston Collaborative Drug Surveillance Program

1979 • 203 citations

Effects of age and cigarette smoking on propranolol disposition

1979 • 186 citations

Lignocaine kinetics in cardiac patients and aged subjects.

1977 • 166 citations

Ethanol Potentiation of Aspirin-Induced Prolongation of the Bleeding Time

1982 • 165 citations

THE EFFECT OF INCREASING AGE ON THE DISTRIBUTION OF PERIPHERAL BLOOD FLOW IN MAN

1965 • 163 citations

Increased Carbon Tetrachloride Hepatotoxicity, and its Mechanism, After Chronic Ethanol Consumption

1974 • 154 citations

Age-related alteration in the activities of drug-metabolizing enzymes and contents of sex-specific forms of cytochrome P-450 in liver microsomes from male and female rats.

1985 • 148 citations

The Relationship between Cognitive Dysfunction and Brain Damage in Alcoholics: Causal, Interactive, or Epiphenomenal?

1981 • 147 citations

The effect of cimetidine on in vitro and in vivo microsomal drug metabolism in the rat

1980 • 147 citations

American Drinking Practices: A National Study of Drinking Behavior and Attitudes.

1970 • 138 citations

Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.

1975 • 135 citations

Stereological analysis of hepatic fine structure in the Fischer 344 rat. Influence of sublobular location and animal age.

1978 • 131 citations

Effect of aging and cigarette smoking on antipyrine and indocyanine green elimination

1979 • 122 citations

Drugs as Indicators of Hepatic Function

1982 • 117 citations

The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis.

1980 • 106 citations

Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity.

1982 • 104 citations

Effects of chronic ethanol feeding on glutathione turnover in the rat

1985 • 101 citations

Interaction of chloral hydrate and ethanol in man: I. Metabolism

1972 • 100 citations

Age-related changes in drug disposition.

1978 • 97 citations

Acetaminophen kinetics in the elderly

1982 • 95 citations

Effect of age on liver function with particular reference to bromsulphalein excretion

1965 • 94 citations

Changes in glutathione in acute and chronic alcohol intoxication

1980 • 88 citations

Ethanol enhancement of cocaine-induced hepatotoxicity

1981 • 82 citations

Alcohol Use Among Older Persons: Findings from a Western New York State General Population Survey

1979 • 81 citations

THE EFFECT OF AGE ON PATHWAYS OF DRUG METABOLISM IN HUMAN LIVER

1984 • 78 citations

Effects of Ethanol on Drug and Metabolite Pharmacokinetics

1985 • 76 citations

Rat Liver Alcohol Dehydrogenase. Purification and Properties.

1971 • 75 citations

UNCERTAINTIES IN GERIATRIC DATA. II. ORGAN SIZE

1965 • 74 citations

Impaired Visual Search in Alcoholics

1978 • 71 citations

Incidence of Polypharmacy in a Long‐Term Care Facility

1977 • 70 citations

Amitriptyline and ethanol: Pharmacokinetic and pharmacodynamic interaction

1983 • 70 citations

Alcohol and Amitriptyline Effects on Skills Related to Driving Behavior

1969 • 70 citations

Effects of aging and phenobarbital on the rat liver microsomal drug-metabolizing system

1981 • 68 citations

Immunochemical studies on the metabolism of nitrosamines by ethanol-inducible cytochrome P-450

1985 • 67 citations

ALCOHOLISM IN ELDERLY MEN: A SURVEY OF A GENERAL MEDICAL WARD

1976 • 67 citations

Ethanol induction of acetaminophen toxicity and metabolism

1980 • 66 citations

Effects of age and alcohol on psychomotor performance of men.

1980 • 66 citations

The aging of rat liver as revealed by electron microscopic morphometry—I. Basic parameters

1975 • 66 citations

Alcohol and the aging process in social drinkers.

1980 • 65 citations

Effect of age on liver function.

1975 • 64 citations

Patterns of legal drug use by older Americans.

1978 • 63 citations

Alcoholism and Premature Aging: A Neuropsychological Perspective

1982 • 61 citations

A Comparison of the Effects of Long‐Term Alcohol Abuse and Aging on the Performance of Verbal and Nonverbal Divided Attention Tasks

1983 • 60 citations

Clinical Pharmacology and the Aged Patient.

1981 • 60 citations

NORMAL VALUES FOR SIXTEEN BLOOD CONSTITUENTS IN THE ELDERLY

1973 • 57 citations

A clinical review of alcohol, alcoholism, and the elderly patient.

1982 • 54 citations

Pharmacokinetics of Salicylates in Elderly

1979 • 53 citations

The Rate of Acetaminophen Metabolism in the Elderly and the Young

1976 • 50 citations

Intravenous diazepam and oral ethanol interaction

1980 • 50 citations

The relationship of age and drinking habits to the effects of alcohol on memory in women.

1980 • 49 citations

The Effects of Aging on the Hepatic Microsomal Mixed–Function Oxidase System of Male and Female Monkeys

1986 • 48 citations

Results of computerized tomography, psychometric testing and dietary studies in social drinkers, with emphasis on reversibility after abstinence

1983 • 47 citations

Characteristics of Ethanol and Acetaldehyde Oxidation on Flavin and Pyridine Nucleotide Fluorescence Changes in Perfused Rat Liver

1974 • 46 citations

Increased hepatic efflux of glutathione after chronic ethanol feeding

1986 • 44 citations

Age-related changes in isolated rat hepatocytes. Comparison of size, morphology, binucleation, and protein content

1981 • 42 citations

Comparison of the hepatic mixed function oxidase system of young, adult, and old non- human primates (Macaca nemestrina)

1985 • 39 citations

Substance use and abuse among the community elderly: the medical aspect.

1978 • 39 citations

Drug Usage and Health Characteristics in Noninstitutional Retired Persons*

1979 • 38 citations

RNA synthesis in rat liver cells with different DNA contents

1978 • 37 citations

Effect of short-term ethanol administration on lorazepam clearance

1981 • 37 citations

Hepatic microsomal drug metabolism, glutamyl transferase activity and in vivo antipyrine half-life in rats chronically fed an ethanol diet, a control diet and a chow diet.

1980 • 36 citations

Impaired Ethanol Metabolism with Advancing Age

1983 • 35 citations

Diagnosis and Treatment of the Elderly Alcoholic

1978 • 35 citations

Subcellular site of acetaldehyde oxidation in rat liver

1976 • 35 citations

Cognitive Patterns Resembling Premature Aging in Male Social Drinkers

1982 • 34 citations

Effect of short- and long-term alcohol use on phenytoin kinetics in chronic alcoholics

1981 • 33 citations

Drug Treatment in the Elderly

1984 • 33 citations

Short-term ethanol administration impairs the elimination of chlordiazepoxide (Librium�) in man

1980 • 31 citations

Hepatic Drug Metabolism in the Elderly

1986 • 31 citations

Effect of Aging on Liver Glutathione Levels and Hepatocellular Injury from Carbon Tetrachloride, Allyl Alcohol or Galactosamine

1984 • 29 citations

Cognitive functioning in alcoholics: The role of subject attrition.

1979 • 23 citations

Aging and Changing Bitterns of Alcohol Use

1981 • 23 citations

The Relationship of Alcohol to Aging and the Elderly

1978 • 21 citations

Cognitive functioning in alcoholics: The role of subject attrition.

1979 • 21 citations

Ethanol and antipyrine clearance

1981 • 21 citations

Mechanism(s) of Ethanol‐Drug Interaction

1984 • 20 citations

Experiences with Elderly Alcoholics in England

1978 • 20 citations

Clearance by the Liver: Current Concepts in Understanding the Hepatic Disposition of Drugs

1983 • 19 citations

Facts, projections, and gaps concerning data on aging.

1984 • 18 citations

Trends in Smoking, Alcohol Consumption, and Other Health Practices Among U.S. Adults, 1977 and 1983

1986 • 18 citations

DRUG INDUCTION OF HEPATIC ENZYMES IN THE ELDERLY

1984 • 17 citations

Complications of Alcohol Use Combined with Drug Therapy in the Elderly

1982 • 17 citations

Age and Alcoholism: Independent Memory Decrements

1984 • 16 citations

Effect of environmental conditions upon age changes in the human liver

1975 • 14 citations

THE PANCREATIC BETA‐CELL RESPONSE TO INTRAVENOUS ADMINISTRATION OF GLUCOSE IN ELDERLY SUBJECTS*

1970 • 14 citations

Alcohol Misuse and Abuse among the Elderly

1984 • 14 citations

Age-related changes in liver drug-metabolizing enzymes

1980 • 12 citations

Alcoholism in the Elderly: Social and Biomedical Issues

1984 • 11 citations

Severe hypothermia due to combination of psychotropic drugs and alcohol.

1966 • 9 citations

Does alcohol intensify the hemodynamic effects of nitroglycerin?

1984 • 6 citations