Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans*

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

1980 • 1,185 citations

Molecular Diagnosis of Thiopurine S-Methyltransferase Deficiency: Genetic Basis for Azathioprine and Mercaptopurine Intolerance

1997 • 765 citations

Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms*

1997 • 396 citations

Human erythrocyte thiopurine methyltransferase: Radiochemical microassay and biochemical properties

1978 • 351 citations

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.

1996 • 321 citations

Thiopurine Methyltransferase Pharmacogenetics: Human Gene Cloning and Characterization of a Common Polymorphism

1996 • 310 citations

A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.

1995 • 303 citations

Enhanced proteolysis of thiopurine S -methyltransferase (TPMT) encoded by mutant alleles in humans ( TPMT ∗ 3 A , TPMT ∗ 2 ): Mechanisms for the genetic polymorphism of TPMT activity

1997 • 265 citations

Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms

1996 • 246 citations

Thiopurine methyltransferase activity in American white subjects and black subjects

1994 • 241 citations

Single-step elimination of contaminating DNA prior to reverse transcriptase PCR.

1992 • 66 citations

Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic library.

1997 • 53 citations

A Neuroendocrine-specific Protein Localized to the Endoplasmic Reticulum by Distal Degradation

1995 • 23 citations