Differential effects of 15-HPETE on arachidonic acid metabolism in collagen-stimulated human platelets

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

1976 • 1,012 citations

Preparation of Suspensions of Washed Platelets from Humans

1972 • 857 citations

The Metabolism of Phosphoinositide-Derived Messenger Molecules

1986 • 717 citations

A new approach to anti-inflammatory drugs

1979 • 501 citations

Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis.

1980 • 481 citations

A new role for phospholipase A2: protection of membranes from lipid peroxidation damage

1987 • 428 citations

Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.

1977 • 409 citations

Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes

1978 • 306 citations

Liberation of [3H]arachidonic acid and changes in cytosolic free calcium in fura-2-loaded human platelets stimulated by ionomycin and collagen

1986 • 292 citations

Formation of lysophosphatidylcholine by human platelets in response to thrombin. Support for the phospholipase A2 pathway for the liberation of arachidonic acid.

1981 • 217 citations

Regulation of arachidonate metabolism via lipoxygenase and cyclo-oxygenase by 12-HPETE, the product of human platelet lipoxygenase

1979 • 208 citations

15-hydroxy-5,8,11,13-eicosatetraenoic acid: A potent and selective inhibitor of platelet lipoxygenase.

1980 • 195 citations

Biochemistry of Platelets

1986 • 194 citations

Regulation of arachidonate-induced platelet aggregation by the lipoxygenase product, 12-hydroperoxyeicosatetraenoic acid

1982 • 155 citations

A role for cyclooxygenase products in the formation of phosphatidic acid in stimulated human platelets. Differential mechanisms of action of thrombin and collagen.

1983 • 135 citations

Collagen stimulates [3H]inositol trisphosphate formation in indomethacin-treated human platelets

1985 • 122 citations

Indomethacin-induced accumulation of diglyceride in activated human platelets. The role of diglyceride lipase.

1980 • 122 citations

Differential hydrolysis of phospholipid molecular species during activation of human platelets with thrombin and collagen.

1987 • 102 citations

Diacylglycerol lipase pathway is a minor source of released arachidonic acid in thrombin-stimulated human platelets

1986 • 90 citations

Measurement of arachidonic acid liberation in thrombin-stimulated human platelets. Use of agents that inhibit both the cyclooxygenase and lipoxygenase enzymes

1985 • 88 citations

Synergistic activation by collagen and 15-hydroxy-9 alpha,11 alpha-peroxidoprosta-5,13-dienoic acid (PGH2) of phosphatidylinositol metabolism and arachidonic acid release in human platelets.

1982 • 76 citations

16 Enzymes in the Biosynthesis and Catabolism of the Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes and Hydroxy Fatty Acids

1983 • 64 citations

15‐hydroperoxyeicosatetraenoic acid inhibits human platelet aggregation

1980 • 44 citations

Enhancement of eicosaenoic acid lipoxygenation in human platelets by 12‐hydroperoxy derivative of arachidonic acid

1985 • 38 citations

Signal Transduction in Collagen-Stimulated Rat Platelets Is Composed of Three Stages

1987 • 30 citations

Two phasic generation of thromboxane a2 by the action of collagen on rat platelets

1987 • 29 citations

Phosphoinositide Breakdown as an Indirect Link between Stimulation and Aggregation of Rat Platelets by Thrombin and Collagen1

1985 • 21 citations

Insufficient Mobilization of Calcium by Early Breakdown of Phosphatidylinositol 4, 5-Bisphosphate for Aggregation of Human Platelets by Collagen1

1985 • 20 citations

Thrombin-induced transfer of arachidonic acid in human platelets is not inhibited by trifluoperazine

1987 • 3 citations