Uric acid as a risk factor for cardiovascular disease

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

Serum Uric Acid and Risk for Cardiovascular Disease and Death: The Framingham Heart Study

1999 • 1,283 citations

The role of adenosine in the regulation of coronary blood flow.

1980 • 877 citations

The effect of insulin on renal sodium metabolism

1981 • 633 citations

Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men

1995 • 542 citations

Two independent mutational events in the loss of urate oxidase during hominoid evolution

1992 • 524 citations

The Management of Gout

1996 • 499 citations

Serum Uric Acid and Cardiovascular Events in Successfully Treated Hypertensive Patients

1999 • 457 citations

Serum Uric Acid Is a Strong Predictor of Stroke in Patients With Non–Insulin-Dependent Diabetes Mellitus

1998 • 419 citations

Antioxidant status in patients with uncomplicated insulin‐dependent and non‐insulin‐dependent diabetes mellitus

1997 • 402 citations

Prenatal Methylmercury Exposure as a Cardiovascular Risk Factor at Seven Years of Age

1999 • 395 citations

PRECURSORS OF ESSENTIAL HYPERTENSION: PULMONARY FUNCTION, HEART RATE, URIC ACID, SERUM CHOLESTEROL, AND OTHER SERUM CHEMISTRIES

1990 • 333 citations

Effect of insulin on renal sodium and uric acid handling in essential hypertension

1996 • 306 citations

Uric acid in chronic heart failure: a marker of chronic inflammation

1998 • 284 citations

Uric Acid and Coronary Heart Disease Risk: Evidence for a Role of Uric Acid in the Obesity-Insulin Resistance Syndrome

1995 • 224 citations

Serum urate and the risk of major coronary heart disease events.

1997 • 219 citations

Association of Serum Uric Acid with All-Cause and Cardiovascular Disease Mortality and Incident Myocardial Infarction in the MONICA Augsburg Cohort

1999 • 215 citations

Relationship of uric acid concentration to cardiovascular risk factors in young men. Role of obesity and central fat distribution. The Verona Young Men Atherosclerosis Risk Factors Study.

1996 • 200 citations

Oxidative stress and cardiovascular disease.

1997 • 189 citations

When and why a water-soluble antioxidant becomes pro-oxidant during copper-induced low-density lipoprotein oxidation: a study using uric acid

1999 • 168 citations

Hyperuricaemia and risk of cardiovascular disease and overall death. A 12-year follow-up of participants in the population study of women in Gothenburg, Sweden.

1988 • 160 citations

Uric acid as an independent risk factor in the treatment of hypertension

1998 • 155 citations

Correlates of uric acid and its association with asymptomatic carotid atherosclerosis: The ARIC study

1996 • 150 citations

Ascorbate prevents prooxidant effects of urate in oxidation of human low density lipoprotein

1999 • 130 citations

Nitrosation of Uric Acid by Peroxynitrite

1998 • 129 citations

Cardiovascular effects of adenosine

1986 • 116 citations

Myocardial malondialdehyde and uric acid release after short-lasting coronary occlusions during coronary angioplasty: Potential mechanisms for free radical generation

1991 • 111 citations

Hyperuricemia as a Risk Factor for Cardiovascular Mortality

1982 • 108 citations

INSULIN AS A VASCULAR HORMONE: IMPLICATIONS FOR THE PATHOPHYSIOLOGY OF CARDIOVASCULAR DISEASE

1998 • 102 citations

Relation between serum uric acid and lower limb blood flow in patients with chronic heart failure.

1997 • 99 citations

Tourniquet-induced Exsanguination in Patients Requiring Lower Limb Surgery

1996 • 97 citations

Evaluation of Renal Handling of Uric Acid in Essential Hypertension: Hyperuricemia Related to Decreased Urate Secretion

1991 • 94 citations

Effect of uric acid and chemical analogues on oxidation of human low density lipoprotein in vitro

1998 • 93 citations

Improvement of Cardiac Function by Allopurinol in Patients Undergoing Cardiac Surgery

1995 • 86 citations

The Pharmacology of Human Blood Vessels in vivo

1995 • 77 citations

Serum uric acid: Its association with other risk factors and with mortality in coronary heart disease

1976 • 76 citations

Serum uric acid and its relation to cardiovascular disease risk factors in children and young adults from a biracial community: the Bogalusa Heart Study.

1991 • 76 citations

Hyperinsulinemia or Increased Sympathetic Drive as Links for Obesity and Hypertension

1991 • 75 citations

Endothelial Dysfunction and Hypertension

1997 • 70 citations

When and why a water-soluble antioxidant becomes pro-oxidant during copper-induced low-density lipoprotein oxidation: a study using uric acid

1999 • 66 citations

Serum uric acid and coronary heart disease

1983 • 62 citations

PREDICTORS OF ATHEROSCLEROSIS IN THE HONOLULU HEART PROGRAM: I. BIOLOGIC, DIETARY, AND LIFESTYLE CHARACTERISTICS

1987 • 62 citations

Identification of Uric Acid in AorticAneurysms and Atherosclerotic Artery

1996 • 60 citations

Mechanisms of Vascular Damage in Gout and Oxalosis: Crystal Induced, Granulocyte Mediated, Endothelial Injury

1983 • 56 citations

Intravascular Source of Adenosine During Forearm Ischemia in Humans

1999 • 54 citations

Is raised serum uric acid a cause of cardiovascular disease or death?

1999 • 54 citations

Superoxide anion production and phagocytosis of crystals by cultured endothelial cells

1993 • 49 citations

Hyperuricemic Nephropathies

1998 • 43 citations

The fever of gout: urate crystals activate endogenous pyrogen production from human and rabbit mononuclear phagocytes.

1983 • 42 citations

Capillary endothelial transport of uric acid in guinea pig heart

1992 • 41 citations

Serum uric acid levels in cardiovascular diseases

1998 • 33 citations

Contribution of Endothelium and Cardiomyocytes to Hypoxia-Induced Adenosine Release

1994 • 29 citations

Localization of the human urate oxidase gene (UOX) to 1p22

1992 • 28 citations

Evaluation of serum uric acid changes in different forms of hepatic vascular inflow occlusion in human liver surgeries

1998 • 27 citations

Nitric oxide in the human cardiovascular system—SKB lecture 1997

1998 • 25 citations

Systemic response to local urate crystal induced inflammation in man: a possible model to study the acute phase response.

1985 • 15 citations

Associations of plasma high-density lipoprotein cholesterol with clinical chemistry data.

1980 • 9 citations