Biochemical markers of myocardial injury. Is MB creatine kinase the choice for the 1990s?

TRANSAMINASE ACTIVITY IN HUMAN BLOOD

1955 • 1,702 citations

The Prognostic Value of Serum Troponin T in Unstable Angina

1992 • 987 citations

THE CREATINE-CREATINE PHOSPHATE ENERGY SHUTTLE

1985 • 746 citations

A Predictive Instrument to Improve Coronary-Care-Unit Admission Practices in Acute Ischemic Heart Disease

1984 • 608 citations

Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction

1991 • 556 citations

Quantitative assessment of the extent of myocardial infarction in the conscious dog by means of analysis of serial changes in serum creatine phosphokinase activity

1971 • 527 citations

Enzyme linked immuno assay of cardiac troponin T for the detection of acute myocardial infarction in patients

1989 • 458 citations

Development and In Vitro Characterization of a New Immunoassay of Cardiac Troponin T

1992 • 438 citations

Development of Monoclonal Antibodies for an Assay of Cardiac Troponin-I and Preliminary Results in Suspected Cases of Myocardial Infarction

1992 • 430 citations

Cardiac-specific troponin-l radioimmunoassay in the diagnosis of acute myocardial infarction

1987 • 425 citations

The Creatine Kinase System in Normal and Diseased Human Myocardium

1985 • 398 citations

Comparison of amino acid sequence of troponin I from different striated muscles

1978 • 372 citations

Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle.

1991 • 372 citations

Specificity of elevated serum MB creatine phosphokinase activity in the diagnosis of acute myocardial infarction

1975 • 289 citations

Effects of Coronary Artery Reperfusion on Myocardial Infarct Size Calculated from Creatine Kinase

1978 • 260 citations

Serum Enzyme Assays in the Diagnosis of Acute Myocardial Infarction Recommendations Based on a Quantitative Analysis

1986 • 260 citations

Cardiac troponin T in diagnosis of acute myocardial infarction

1991 • 228 citations

Analysis of Myosin Light and Heavy Chain Types in Single Human Skeletal Muscle Fibers

1981 • 226 citations

Troponin I Switching in the Developing Heart

1989 • 212 citations

Effects of electrical countershock on serum creatine phosphokinase (CPK) isoenzyme activity

1976 • 210 citations

Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction

1991 • 207 citations

Isoenzymes of creatine phosphokinase in tissue extracts and in normal and pathological sera

1966 • 207 citations

Left Ventricular Function and Rapid Release of Creatine Kinase MB in Acute Myocardial Infarction

1983 • 173 citations

Differentiation of troponin in cardiac and skeletal muscles in chicken embryos as studied by immunofluorescence microscopy.

1981 • 172 citations

Non-invasive assessment of perioperative myocardial cell damage by circulating cardiac troponin T.

1991 • 168 citations

Early enzyme release from myocardial cells is not due to irreversible cell damage*

1984 • 155 citations

Comparison of enzymatic and anatomic estimates of myocardial infarct size in man.

1984 • 153 citations

Prediction of infarct coronary artery recanalization after intravenous thrombolytic therapy

1987 • 148 citations

Cardiac troponin T in developing, regenerating and denervated rat skeletal muscle

1990 • 141 citations

Comparison of serum cardiac specific troponin‐I with creatine kinase, creatine kinase‐MB isoenzyme, tropomyosin, myoglobin and C‐reactive protein release in marathon runners: cardiac or skeletal muscle trauma?

1987 • 129 citations

Comparison of turnover of several myofibrillar proteins and critical evaluation of double isotope method.

1977 • 129 citations

Chemical Studies on Light Chains from Cardiac and Skeletal Muscle Myosins

1971 • 126 citations

Macro creatine kinase BB in serum, and some data on its prevalence.

1979 • 119 citations

Tissue-specific distribution and developmental regulation of M and B creatine kinase mRNAs

1990 • 110 citations

Diagnosis of acute myocardial infarction by detection of circulating cardiac myosin light chains

1984 • 108 citations

Myoglobinemia following acute myocardial infarction

1975 • 104 citations

Relation between infarct size and left ventricular performance assessed in patients with first acute myocardial infarction randomized to intracoronary thrombolytic therapy or to conventional treatment

1988 • 103 citations

Creatine kinase release not associated with myocardial necrosis after short periods of coronary artery occlusion in conscious baboons

1985 • 103 citations

Developmental expression of troponin I isoforms in fetal human heart

1991 • 103 citations

Cloning, structural analysis, and expression of the human slow twitch skeletal muscle/cardiac troponin C gene.

1990 • 103 citations

Elevated Skeletal Muscle Creatine Kinase MB Isoenzyme Levels in Marathon Runners

1983 • 97 citations

Detection of coronary artery reperfusion with creatine kinase-MB determinations during thrombolytic therapy: Correlation with acute angiography

1988 • 93 citations

CHEMICAL DIFFERENCES BETWEEN MULTIPLE FORMS OF LACTIC ACID DEHYDROGENASES*

1961 • 93 citations

Purification and characterization of naturally occurring and in vitro induced multiple forms of MM creatine kinase.

1984 • 88 citations

Lactic dehydrogenase isoenzymes in blood serum after storage at different temperatures

1964 • 86 citations

Measurement of rat heart fatty acid binding protein by ELISA. Tissue distribution, developmental changes and subcellular distribution*

1987 • 85 citations

Peak creatine kinase as a measure of effectiveness of thrombolytic therapy in acute myocardial infarction

1987 • 84 citations

Post-synthetic changes in creatine kinase isozymes (EC 2.7.3.2)

1978 • 83 citations

cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I

1990 • 82 citations

Myoglobinemia in the early phase of acute myocardial infarction

1983 • 78 citations

Creatine kinase isoenzymes in extracts of various human skeletal muscles.

1986 • 77 citations

Leakage of heart fatty acid binding protein with ischemia and reperfusion in the rat

1989 • 76 citations

Serum myoglobin in myocardial infarction: The “staccato phenomenon”

1977 • 75 citations

Non-invasive assessment of infarct reperfusion: the predictive power of the time to peak value of myoglobin, CKMB, and CK in serum

1988 • 73 citations

Sensitive, rapid assay of subforms of creatine kinase MB in plasma.

1989 • 71 citations

Plasma mb creatine kinase after vigorous exercise in professional athletes

1984 • 68 citations

Structural characterization and tissue-specific expression of the mRNAs encoding isoenzymes from two rat mitochondrial creatine kinase genes

1991 • 68 citations

Influence of reperfusion on serum concentrations of cytosolic creatine kinase and structural myosin light chains in acute myocardial infarction

1987 • 62 citations

Electrophoretic Pattern of Lactic Dehydrogenase in Carriers and Patients with Duchenne Muscular Dystrophy

1964 • 59 citations

Circulating cardiac myosin light chains in patients with angina at rest: Identification of a high risk subgroup

1988 • 59 citations

Creatine Kinase: Stability, Inactivation, Reactivation

1977 • 56 citations

Usefulness of serial determinations of myoglobin and creatine kinase in serum compared for assessment of acute myocardial infarction.

1983 • 56 citations

Receptor-mediated endocytosis of lactate dehydrogenase M4 by liver macrophages: a mechanism for elimination of enzymes from plasma. Evidence for competition by creatine kinase MM, adenylate kinase, malate, and alcohol dehydrogenase.

1987 • 55 citations

Differentiating muscle damage from myocardial injury by means of the serum creatine kinase (CK) isoenzyme MB mass measurement/total CK activity ratio.

1986 • 51 citations

Enolase: human tissue distribution and evidence for three different loci*

1976 • 50 citations

Serum creatine kinase MB isoenzyme in chronic muscle disease.

1984 • 47 citations

Noninvasive detection of reperfusion in acute myocardial infarction based on plasma activity of creatine kinase MB subforms

1991 • 46 citations

Serum Myoglobin Levels in Patients With Ischemic Myocardial Insult

1988 • 44 citations

Three rapid immunoassays for the determination of creatine kinase MB: An analytical, clinical, and interpretive evaluation

1991 • 42 citations

The nature of post-translational formation of MM creatine kinase isoforms.

1985 • 38 citations

Conversion of MM creatine kinase isoforms in human plasma by carboxypeptidase N.

1987 • 38 citations

Assay of serum cardiac myosin heavy chain fragments in patients with acute myocardial infarction: Determination of infarct size and long-term follow-up

1990 • 37 citations

Prompt detection of coronary recanalization by analysis of rates of change of concentrations of macromolecular markers in plasma

1991 • 36 citations

Indices of reperfusion in patients with acute myocardial infarction using characteristics of the CK-MB time-activity curve

1991 • 35 citations

Characteristics of creatine kinase-MB and MB isoforms in serum after reperfusion in acute myocardial infarction.

1989 • 35 citations

Abnormal technetium-99m pyrophosphate images in unstable angina: Ischemia versus infarction?

1979 • 34 citations

Serum Lactate Dehydrogenase Isoenzyme 1 as a Marker of Testicular Germ Cell Tumor

1988 • 33 citations

Tissue Specific and Subcellular Distribution of Creatine Kinase Isoenzymes

1981 • 32 citations

Isoforms of creatine kinase MM and MB in acute myocardial infarction: a clinical evaluation

1986 • 31 citations

The human cardiac troponin I locus: assignment to chromosome 19p13.2?19q13.2

1991 • 31 citations

Paucity of subtle myocardial injury after angioplasty delineated with MB CK

1986 • 30 citations

Myosin: A highly sensitive indicator of myocardial necrosis after cardiac operations

1989 • 30 citations

Patterns of myoglobin and MM creatine kinase isoforms release early after intravenous thrombolysis or direct percutaneous transluminal coronary angioplasty for acute myocardial infarction, and implications for the early noninvasive diagnosis of reperfusion

1992 • 28 citations

Serum creatine kinase isoenzyme pattern in nervous system atrophies and neuromuscular disorders

1976 • 28 citations

The prognostic significance of immunoradiometric CK-MB assay (IRMA) diagnosis of myocardial infarction in patients with low total CK and elevated MB isoenzymes

1989 • 28 citations

Increase in Creatine Kinase MB Isoenzyme Levels after Spinal Surgery

1994 • 28 citations

Creatine kinase and lactate dehydrogenase isoenzymes in serum of patients suffering burns, blunt trauma, or myocardial infarction.

1984 • 27 citations

Detection of reperfusion within 1 hour after coronary recanalisation by analysis of isoforms of the MM creatine kinase isoenzyme in plasma

1988 • 27 citations

Estimation of infarct size with MB rather than total CK

1983 • 26 citations

Technetium-99m stannous pyrophosphate scintigrams in normal subjects, patients with exercise-induced ischemia and patients with a calcified valve

1977 • 26 citations

Changes in the ratio of lactate dehydrogenase isoenzymes 1 and 2 during the first day after acute myocardial infarction.

1985 • 25 citations

Prompt detection of myocardial injury by assay of creatine kinase isoforms in initial plasma samples

1988 • 25 citations

Amino acid sequence of rabbit ventricular myosin light chain-2: Identity with the slow skeletal muscle isoform

1986 • 24 citations

Characterization of MB creatine kinase isoform conversion in vitro and in vivo in dogs.

1989 • 24 citations

Nature and time course of generation of creatine kinase, MB fraction in vivo

1992 • 23 citations

Concordance of creatine kinase-MB activity and mass.

1989 • 22 citations

Expression of troponin T in atria and ventricles of avian and mammalian hearts

1986 • 20 citations

Identification and localization of creatine kinase B and M in normal, ischemic and necrotic myocardium. An immunohistochemical study

1984 • 18 citations

Electrophoresis of serum isoenzymes and proteins following acute myocardial infarction

1991 • 18 citations

Optimal criteria for rapid detection of myocardial reperfusion by creatine kinase MM isoforms in the presence of residual high grade coronary stenosis

1989 • 17 citations

Quantitative analysis for isoforms of creatine kinase MM in plasma by chromatofocusing, with on-line monitoring of enzyme activity.

1988 • 17 citations

Complexity of enzyme release during acute myocardial infarction in a controlled study with early nifedipine treatment

1985 • 17 citations

Changes in myosin and creatine kinase mRNA levels with cardiac hypertrophy and hypothyroidism

1990 • 16 citations

Perioperative mortality rate in patients with unstable angina selected by exclusion of myocardial infarction

1977 • 15 citations

Serum beta-enolase in acute myocardial infarction.

1987 • 15 citations

Evaluation of the effect of thrombolytic treatment on infarct size and left ventricular function by enzymatic, scintigraphic, and angiographic methods

1990 • 15 citations

Prognostic implications of an early peak in plasma MB creatine kinase in patients with acute myocardial infarction

1987 • 15 citations

Early detection of coronary artery patency after thrombolysis by determination of the MM creatine kinase isoforms in patients with acute myocardial infarction

1992 • 14 citations

Effects of early thrombolytic therapy (anistreplase versus streptokinase) on enzymatic and electrocardiographic infarct size in acute myocardial infarction

1991 • 14 citations

Purification and determination of the modifying protein responsible for the post-synthetic modification of creatine kinase (EC 2.7.3.2) and enolase(EC 4.2.1.11)

1985 • 13 citations

"Flipped" patterns of lactate dehydrogenase isoenzymes in serum of elite college basketball players.

1988 • 13 citations

The effect of hemolysis on creatine kinase determination.

1989 • 13 citations

Enzymatic Estimation: Creatine Kinase

1982 • 12 citations

Semi-automated direct colorimetric measurement of creatine kinase isoenzyme MB activity after extraction from serum by use of a CK-MB-specific monoclonal antibody.

1988 • 12 citations

Diagnostic efficiency of four lactate dehydrogenase isoenzyme-1 ratios in serum after myocardial infarction.

1988 • 12 citations

Serum myoglobin in detection of myocardial necrosis in patients with “coronary insufficiency”

1987 • 11 citations

Serum Enolase and Pyruvate Kinase Activities in the Diagnosis of Myocardial Infarction

1976 • 11 citations

Optimized preservation of isoforms of creatine kinase MM isoenzyme in plasma specimens and their rapid quantification by semi-automated chromatofocusing

1990 • 9 citations

Physiologic modelling of MM creatine kinase isoforms

1988 • 8 citations

Myocardial Infarct Size from Serum Cardiac Myosin Light Chain

1983 • 8 citations

Elevation of creatine kinase BB CK in hospitalized patients. Importance of distinguishing BB CK from MB CK.

1982 • 6 citations

Significance of elevated MB creatine kinase in patients after cardiac catheterization

1984 • 6 citations

-Enolase in blood plasma during open heart surgery

1989 • 5 citations

The typical staccato phenomenon of myoglobin in acute myocardial infarction disappears under thrombolytic treatment

1987 • 4 citations