Enzymatic Estimation: Creatine Kinase

Quantitative assessment of the extent of myocardial infarction in the conscious dog by means of analysis of serial changes in serum creatine phosphokinase activity

1971 • 527 citations

Creatine Kinase of Rat Heart Mitochondria

1973 • 467 citations

A NEW CORONARY PROGNOSTIC INDEX

1969 • 460 citations

An improved basis for enzymatic estimation of infarct size.

1975 • 355 citations

High activity of creatine kinase in mitochondria from muscle and brain and evidence for a separate mitochondrial isoenzyme of creatine kinase

1964 • 341 citations

The influence of location and extent of myocardial infarction on long-term ventricular dysrhythmia and mortality.

1979 • 320 citations

Reduction of Experimental Myocardial Infarct Size by Corticosteroid Administration

1973 • 290 citations

Specificity of elevated serum MB creatine phosphokinase activity in the diagnosis of acute myocardial infarction

1975 • 289 citations

Deleterious effects due to hemorrhage after myocardial reperfusion

1974 • 280 citations

Deleterious effects of methylprednisolone in patients with myocardial infarction.

1976 • 275 citations

Separation of Tissue and Serum Creatine Kinase Isoenzymes by Ion-Exchange Column Chromatography

1974 • 266 citations

Clinical measurement of myocardial infarct size. Modification of a method for the estimation of total creatine phosphokinase release after myocardial infarction.

1975 • 257 citations

Complication rate of coronary arteriography. A review of 5250 cases studied by a percutaneous femoral technique.

1976 • 242 citations

Effects of nifedipine on myocardial perfusion and ischemic injury in dogs.

1978 • 239 citations

The changing anatomic reference base of evolving myocardial infarction. Underestimation of myocardial collateral blood flow and overestimation of experimental anatomic infarct size due to tissue edema, hemorrhage and acute inflammation.

1979 • 230 citations

Reduction of enzyme levels by propranolol after acute myocardial infarction.

1978 • 221 citations

Creatine kinase isoenzyme patterns in human tissue obtained at surgery.

1976 • 220 citations

Depressed Myocardial Creatine Phosphokinase Activity Following Experimental Myocardial Infarction in Rabbit

1970 • 220 citations

Protection of Jeopardized Ischemic Myocardium by Reduction of Ventricular Afterload

1974 • 211 citations

Isoenzymes of creatine phosphokinase in tissue extracts and in normal and pathological sera

1966 • 207 citations

Experimental infarct size as a function of the amount of myocardium at risk.

1978 • 207 citations

Medicine and the Law

1974 • 197 citations

Effects of dobutamine in patients with acute myocardial infarction

1977 • 194 citations

Combined isoenzyme analysis in the diagnosis of myocardial injury: application of electrophoretic methods for the detection and quantitation of the creatine phosphokinase MB isoenzyme.

1972 • 192 citations

Evaluation of precordial electrocardiographic mapping as a means of assessing changes in myocardial ischemic injury.

1975 • 189 citations

Infarct size estimated from serial serum creatine phosphokinase in relation to left ventricular hemodynamics.

1977 • 182 citations

Quantification of serum creatine phosphokinase isoenzyme activity

1974 • 166 citations

Reduction by Hyaluronidase of Myocardial Necrosis following Coronary Artery Occlusion

1972 • 165 citations

Simplified method for histochemical demonstration of experimental myocardial infarct

1979 • 164 citations

Enzymatic indices of myocardial necrosis: influence on short- and long-term prognosis after myocardial infarction.

1979 • 161 citations

Relation between infarct size and ventricular arrhythmia.

1975 • 160 citations

Localization of creatine kinase isoenzymes in myofibrils. I. Chicken skeletal muscle.

1977 • 158 citations

Evidence for Increased Serum Glutamic Oxalacetic Transaminase (SGO-T) Activity Following Graded Myocardial Infarcts in Dogs

1955 • 154 citations

Localization of creatine kinase isoenzymes in myofibrils. II. Chicken heart muscle.

1977 • 152 citations

Distribution of myocardial injury and its relation to epicardial ST-segment changes after coronary artery occlusion in the dog

1972 • 142 citations

Creatine kinase isoenzymes in the assessment of heart disease

1978 • 140 citations

Rapid Separation of Plasma Creatine Kinase Isoenzymes by Batch Adsorption on Glass Beads

1975 • 133 citations

Effects of verapamil on infarct size following experimental coronary occlusion

1975 • 133 citations

Attempt to quantitate relation between cardiac function and infarct size in acute myocardial infarction.

1974 • 129 citations

Serum Transaminase Levels in Experimental Myocardial Infarction

1955 • 126 citations

Quantification of infarction in cross sections of canine myocardium in vivo with positron emission transaxial tomography and 11C-palmitate.

1977 • 125 citations

Absence of a lateral border zone of intermediate creatine phosphokinase depletion surrounding a central infarct 24 hours after acute coronary occlusion in the dog.

1977 • 123 citations

Correlation of angiographic estimates of myocardial infarct size and accumulated release of creatine kinase MB isoenzyme in man.

1977 • 116 citations

Hyaluronidase-Induced Reductions in Myocardial Infarct Size

1976 • 112 citations

Determination of serum creatine kinase isoenzymes in myocardial infarction

1972 • 101 citations

Left Ventricular Performance after Myocardial Infarction Assessed by Radioisotope Angiocardiography

1973 • 100 citations

Effect of reperfusion on myocardial infarct, and the accuracy of estimating infarct size from serum creatine phosphokinase in the dog

1976 • 96 citations

The association of increased plasma MB CPK activity and irreversible ischemic myocardial injury in the dog.

1976 • 94 citations

Detection of myocardial infarction in vitro based on altered attenuation of ultrasound.

1977 • 92 citations

Progressive nature of myocardial injury in selected patients with cardiogenic shock

1978 • 85 citations

Electrophoresis on Cellulose Acetate and Chromatography on DEAE-Sephadex A-50 Compared in the Estimation of Creatine Kinase Isoenzymes

1975 • 81 citations

An isoenzyme of creatine phosphokinase associated with rabbit heart mitochondria

1972 • 72 citations

Augmentation of serum CPK activity by digitalis in patients with acute myocardial infarction.

1977 • 70 citations

The effect of propranolol on microvascular injury in acute myocardial ischemia.

1977 • 69 citations

Purification of mitochondrial creatine kinase. Biochemical and immunological characterization.

1980 • 68 citations

Lack of protection of ischemic myocardium by verapamil in conscious dogs

1977 • 64 citations

Creatine kinase MB isoenzyme studies in diagnosis of myocardial infarction.

1976 • 64 citations

The influence of occult right ventricular infarction on enzymatically estimated infarct size, hemodynamics and prognosis.

1980 • 62 citations

DIAGNOSTIC VALUE OF SERUM-CREATINE-KINASE IN A CORONARY-CARE UNIT

1967 • 59 citations

Diagnostic accuracy of serum enzyme assays for myocardial infarction in a general hospital population.

1972 • 57 citations

Relations between enzymatically estimated myocardial infarct size and early ventricular dysrhythmia.

1976 • 56 citations

Myocardial infarction size from serial CPK: variability of CPK serum entry ratio with size and model of infarction.

1978 • 52 citations

The nature of disappearance of creatine kinase from the circulation and its influence on enzymatic estimation of infarct size.

1977 • 51 citations

Creatine kinase isoenzymes: their separation and quantitation

1977 • 51 citations

Protection of hypoxic guinea pig hearts with glucose and insulin

1974 • 46 citations

Effects of lymphatic transport of enzyme on plasma creatine kinase time-activity curves after myocardial infarction in dogs.

1978 • 45 citations

Enzyme release resulting from total ischemia and reperfusion in the isolated, perfused guinea pig heart

1975 • 45 citations

Elevated Plasma MB Creatine Phosphokinase Activity

1976 • 44 citations

Reduction of early ventricular arrhythmia by acebutolol in patients with acute myocardial infarction.

1979 • 42 citations

Transaminase in Experimental Myocardial Infarction

1955 • 41 citations

Factors influencing enzymatic estimates of infarct size

1977 • 40 citations

Nonlinear relationship between creatine kinase estimates and histologic extent of infarction in conscious dogs: effects of regional myocardial blood flow.

1980 • 31 citations

Effect of selected drugs and myocardial infarction on the disappearance of creatine kinase from the circulation in conscious dogs

1977 • 31 citations

Serial serum creatine phosphokinase MB isoenzyme activity after myocardial infarction. Studies in the baboon and man.

1977 • 31 citations

Infarct size and exercise capacity after myocardial infarction

1977 • 29 citations

Technetium-99m stannous pyrophosphate scintigrams in normal subjects, patients with exercise-induced ischemia and patients with a calcified valve

1977 • 26 citations

Quantitative estimation of lactate dehydrogenase isoenzymes in serum. I. Review of methods and distribution in human tissues.

1969 • 24 citations

A METHOD FOR THE QUANTITATION OF MYOCARDIAL INFARCTS AND THE RELATION OF SERUM ENZYME LEVELS TO INFARCT SIZE.

1964 • 22 citations

Serum CPK isoenzymes after cardiac catheterization.

1975 • 21 citations

Plasma MB Creatine Kinase Activity and Other Conventional Enzymes

1980 • 19 citations

Interpretive Enzymology.

1968 • 17 citations

Perioperative mortality rate in patients with unstable angina selected by exclusion of myocardial infarction

1977 • 15 citations

Enzyme content of canine cardiac lymph during acute myocardial infarction.

1974 • 13 citations

Effects of external counterpulsation on enzymatically estimated infarct size and ventricular arrhythmia.

1978 • 12 citations

Elevated plasma MB creatine phosphokinase activity. A specific marker for myocardial infarction in perioperative patients

1976 • 11 citations

Über die Vasektomie als Behandlungs-Methode der Prostatahypertrophie

1923 • 10 citations

Assessment of myocardial injury with creatine phosphokinase (CPK).

1976 • 10 citations

An ethical consideration of large-scale clinical trials in cardiovascular diseases. Report of the Committee on Ethics of the American Heart Association.

1975 • 9 citations

The effect of intravenous nitroglycerin on coronary blood flow and infarct size during myocardial infarction in conscious dogs

1980 • 5 citations

Methods in the study of isoenzymes

1974 • 4 citations

Detection of elevated mitochondrial ck in plasma after infarction by a specific radioimmunoassay

1980 • 2 citations

Plasma MB creatine kinase activity and other conventional enzymes. Comparison in patients with chest pain and tachyarrhythmias

1980 • 2 citations

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