Intercellular Transfer of the Cellular Prion Protein

Functional rafts in cell membranes

1997 • 9,471 citations

Prions

1998 • 5,102 citations

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

1993 • 2,237 citations

Prion Diseases of Humans and Animals: Their Causes and Molecular Basis

2001 • 1,307 citations

The cellular prion protein binds copper in vivo

1997 • 1,263 citations

Scrapie prion protein contains a phosphatidylinositol glycolipid

1987 • 1,104 citations

The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes

1993 • 896 citations

Signal Transduction Through Prion Protein

2000 • 786 citations

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

1991 • 627 citations

Emerging Themes in Lipid Rafts and Caveolae

2001 • 567 citations

Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform [published erratum appears in J Cell Biol 1995 Jul;130(2):501]

1995 • 541 citations

Normal prion protein has an activity like that of superoxide dismutase

1999 • 520 citations

Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

1996 • 516 citations

Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation

1997 • 515 citations

Evidence for synthesis of scrapie prion proteins in the endocytic pathway.

1992 • 497 citations

Nearly ubiquitous tissue distribution of the scrapie agent precursor protein

1992 • 468 citations

The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein

2001 • 422 citations

Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells

1993 • 391 citations

Characterization of Detergent-insoluble Complexes Containing the Cellular Prion Protein and Its Scrapie Isoform

1997 • 388 citations

Functionally different GPI proteins are organized in different domains on the neuronal surface

1999 • 363 citations

Activation of protein kinase C precedes alpha 5 beta 1 integrin-mediated cell spreading on fibronectin.

1993 • 358 citations

Pathogenesis of Scrapie Virus Infection in the Mouse

1967 • 342 citations

A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells

1993 • 311 citations

Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor

2001 • 278 citations

Synthesis and trafficking of prion proteins in cultured cells.

1992 • 268 citations

Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrPSc) into contiguous membranes

2002 • 261 citations

In Vivo Transfer of GPI-Linked Complement Restriction Factors from Erythrocytes to the Endothelium

1995 • 254 citations

Prion Protein Binds Copper within the Physiological Concentration Range

2001 • 249 citations

SCRAPIE PRIONS

1989 • 239 citations

Chaperone-supervised conversion of prion protein to its protease-resistant form

1997 • 232 citations

COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform

1997 • 232 citations

Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells

2001 • 222 citations

Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state

1999 • 222 citations

Etiology and pathogenesis of prion diseases.

1995 • 212 citations

Prion protein expression in different species: Analysis with a panel of new mAbs

1998 • 198 citations

Evolution of Lipidic Structures during Model Membrane Fusion and the Relation of This Process to Cell Membrane Fusion

1997 • 182 citations

Pathogenesis of Scrapie in the Mouse: the Role of the Spleen

1970 • 170 citations

Intracellular transport of GPI-anchored proteins

2000 • 167 citations

MARCKS regulates membrane ruffling and cell spreading

1997 • 161 citations

Inner but Not Outer Membrane Leaflets Control the Transition from Glycosylphosphatidylinositol-anchored Influenza Hemagglutinin-induced Hemifusion to Full Fusion

1997 • 153 citations

Lipid distribution and transport across cellular membranes

2001 • 146 citations

Effect of the D178N Mutation and the Codon 129 Polymorphism on the Metabolism of the Prion Protein

1996 • 143 citations

Mutant and Infectious Prion Proteins Display Common Biochemical Properties in Cultured Cells

1996 • 139 citations

Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine.

1992 • 133 citations

Amelioration of lytic abnormalities of paroxysmal nocturnal hemoglobinuria with decay-accelerating factor.

1985 • 117 citations

Identification of an epitope in the C terminus of normal prion protein whose expression is modulated by binding events in the N terminus 1 1Edited by F. Cohen

2000 • 115 citations

Differential Contribution of Superoxide Dismutase Activity by Prion Protein in Vivo

2000 • 107 citations

Detection of Prion Protein mRNA in Normal and Scrapie-infected Tissues and Cell Lines

1988 • 91 citations

Similar Turnover and Shedding of the Cellular Prion Protein in Primary Lymphoid and Neuronal Cells

2001 • 88 citations

Phorbol Ester-induced Disruption of the CD4-Lck Complex Occurs within a Detergent-resistant Microdomain of the Plasma Membrane

1999 • 85 citations

Transfer of exogenous glycosylphos-phatidylinositol (GPI)-linked molecules to plasma membranes

1996 • 79 citations

Inhibition of Interactions and Interconversions of Prion Protein Isoforms by Peptide Fragments from the C-terminal Folded Domain

2001 • 71 citations

Normal Cellular Prior Protein Is Preferentially Expressed on Subpopulations of Murine Hemopoietic Cells

2001 • 63 citations

Differential expression of cellular prion protein in mouse brain as detected with multiple anti-PrP monoclonal antibodies

2001 • 63 citations

Mitogenic stimulation of the host enhances susceptibility to scrapie

1978 • 58 citations

Intercellular transfer of a glycosylphosphatidylinositol (GPI)-linked protein: release and uptake of CD4-GPI from recombinant adeno-associated virus-transduced HeLa cells.

1996 • 55 citations

Isolation of plasma membrane fragments from cultured murine melanoma cells

1983 • 52 citations

Calcium‐dependent association of annexin VI, protein kinase Cα, and neurocalcinα on the raft fraction derived from the synaptic plasma membrane of rat brain

2001 • 51 citations

Antigen-presenting cell engineering. The molecular toolbox.

1996 • 39 citations

Isolation of plasma membrane domains from murine T lymphocytes.

1983 • 33 citations

Lipid and membrane protein transfer from human neutrophils to schistosomes is mediated by ligand binding

1993 • 23 citations

Lipid Transfer from Human Epithelial Cells to Pneumocystis carinii In Vitro

1997 • 19 citations

Dynamics of glycolipid domains in the plasma membrane of living cultured neurons, following protein kinase C activation: a study performed by excimer-formation imaging

1999 • 16 citations

Effect of Vaccinia-Activated Macrophages on Scrapie Infection in Hamsters

1981 • 16 citations

Psychiatric presentation of Jakob-Creutzfeldt disease.

1979 • 14 citations

Macrophage Protein Kinase C: Its Role in Modulating Membrane Microviscosity and Superoxide in Leishmanial Infection

2000 • 13 citations

Variegated transfer of recombinant glycosylphosphatidylinositol-anchored CD4 among cultured cells: Correlation of flow cytometric and microscopic observations

1998 • 7 citations

Mechanisms of phenotypic heterogeneity in prion, Alzheimer and other conformational diseases

2001 • 6 citations