Modal gating of NMDA receptors and the shape of their synaptic response

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Glutamate receptor ion channels

2005 • 3,667 citations

An Energy Budget for Signaling in the Grey Matter of the Brain

2001 • 3,148 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

The Time Course of Glutamate in the Synaptic Cleft

1992 • 1,071 citations

N-methyl-D-aspartic acid receptor structure and function

1994 • 989 citations

Rates and equilibria of organic reactions

1963 • 946 citations

The Tetrameric Structure of a Glutamate Receptor Channel

1998 • 790 citations

Glutamate activates multiple single channel conductances in hippocampal neurons

1987 • 691 citations

Functional and Pharmacological Differences Between RecombinantN-Methyl-<scp>d</scp>-Aspartate Receptors

1998 • 662 citations

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

1980 • 608 citations

Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents

1990 • 570 citations

NMDA channel behavior depends on agonist affinity

1992 • 401 citations

Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices

1990 • 396 citations

Slow excitatory postsynaptic currents mediated by N‐methyl‐D‐aspartate receptors on cultured mouse central neurones.

1988 • 364 citations

Rates and equilibria of organic reactions as treated by statistical, thermodynamic, and extrathermodynamic methods

1989 • 348 citations

A quantitative description of NMDA receptor-channel kinetic behavior

1990 • 323 citations

Maximum likelihood estimation of aggregated Markov processes

1997 • 273 citations

A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux

2001 • 245 citations

Single‐channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors

1998 • 231 citations

Activation of NR1/NR2B NMDA receptors

2003 • 210 citations

Burst kinetics of single calcium‐activated potassium channels in cultured rat muscle.

1983 • 174 citations

High Probability Opening of NMDA Receptor Channels by L-Glutamate

1992 • 166 citations

Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors

1995 • 143 citations

Currents through single glutamate receptor channels in outside‐out patches from rat cerebellar granule cells.

1991 • 129 citations

Stoichiometry of Recombinant N-Methyl-<scp>d</scp>-Aspartate Receptor Channels Inferred from Single-channel Current Patterns

1997 • 119 citations

Mode Switching Kinetics Produced by a Naturally Occurring Mutation in the Cytoplasmic Loop of the Human Acetylcholine Receptor ε Subunit

1998 • 114 citations

Identification of a High Affinity Divalent Cation Binding Site near the Entrance of the NMDA Receptor Channel

1996 • 99 citations

Glutamate activation of a single NMDA receptorchannel produces a cluster of channel openings

1991 • 99 citations

The dissociation of acetylcholine from open nicotinic receptor channels

2001 • 95 citations

Altered Prevalence of Gating Modes in Neurotransmitter Inhibition of N-Type Calcium Channels

1993 • 93 citations

Multiple modes of N-type calcium channel activity distinguished by differences in gating kinetics

1993 • 91 citations

Single channel properties of cloned NMDA receptors in a human cell line: comparison with results from Xenopus oocytes.

1994 • 79 citations

A plant Shaker‐like K⁺ channel switches between two distinct gating modes resulting in either inward‐rectifying or ‘leak’ current

2001 • 73 citations

On the kinetics of large-conductance glutamate-receptor ion channels in rat cerebellar granule neurons

1988 • 72 citations

Heterogeneous kinetic properties of acetylcholine receptor channels in Xenopus myocytes.

1986 • 65 citations

Modal Shifts in Acetylcholine Receptor Channel Gating Confer Subunit-Dependent Desensitization

1993 • 59 citations

Muscarinic K+ Channel in the Heart

1998 • 40 citations

Multiple kinetic components of sodium channel inactivation in rabbit Schwann cells.

1992 • 40 citations

Na+ Occupancy and Mg2+ Block of the N-Methyl-<scp>d</scp>-Aspartate Receptor Channel

2001 • 39 citations

Slow modal gating of single G protein‐activated K⁺ channels expressed in Xenopus oocytes

2000 • 31 citations

Burst kinetics of single NMDA receptor currents in cell‐attached patches from rat brain cortical neurons in culture.

1995 • 26 citations

Bimodal Kinetics of a Chloride Channel from Human Fibroblasts

1999 • 6 citations