Putative Role of Dihydropyrimidine Dehydrogenase in the Toxic Side Effect of 5-Fluorouracil in Colorectal Cancer Patients

Manual of pharmacologic calculations with computer programs

1988 • 1,456 citations

Fluorouracil: biochemistry and pharmacology.

1988 • 825 citations

Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity.

1988 • 500 citations

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion.

1990 • 443 citations

Population study of dihydropyrimidine dehydrogenase in cancer patients.

1994 • 428 citations

Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy.

1993 • 371 citations

Response to fluorouracil therapy in cancer patients: the role of tumoral dihydropyrimidine dehydrogenase activity.

1995 • 287 citations

Studies on fluorinated pyrimidines. IV. Effects on nucleic acid metabolism in vivo.

1958 • 259 citations

Familial Pyrimidinemia and Pyrimidinuria Associated with Severe Fluorouracil Toxicity

1985 • 254 citations

Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients.

1992 • 233 citations

Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome

1991 • 225 citations

Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency.

1996 • 164 citations

Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase

1981 • 137 citations

cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.

1994 • 121 citations

Dihydropyrimidine dehydrogenase activity and fluorouracil chemotherapy.

1994 • 104 citations

5-Fluoro-2'-deoxyuridine incorporation in L1210 DNA.

1981 • 103 citations

Relationship between circadian-dependent toxicity of 5-fluorodeoxyuridine and circadian rhythms of pyrimidine enzymes: possible relevance to fluoropyrimidine chemotherapy.

1993 • 101 citations

Link between dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells and liver.

1996 • 97 citations

Dihydropyrimidine dehydrogenase activity in cancer patients

1993 • 86 citations

The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts

1982 • 62 citations

Dihydropyrimidine dehydrogenase (DPD) and clinical pharmacology of 5-fluorouracil (review).

1994 • 56 citations

Resistance to antimetabolites

1996 • 52 citations

The biology of colorectal cancer. Implications for pretreatment and follow-up management

1993 • 49 citations

Decreased Catabolism of Fluorouracil in Peripheral Blood Mononuclear Cells During Combination Therapy With Fluorouracil, Leucovorin, and Interferon -2a

1992 • 44 citations

The effect of 5-fluorouracil on the synthesis and methylation of low molecular weight nuclear RNA in L1210 cells.

1980 • 43 citations

The effect of 5-fluorouracil on the synthesis of nuclear RNA in L1210 cells in vitro.

1979 • 39 citations

Structure-activity relationship of ligands of dihydrouracil dehydrogenase from mouse liver

1989 • 35 citations

Dihydropyrimidine dehydrogenase deficiency presenting with psychomotor retardation and ocular abnormalities

1994 • 7 citations