cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Cancer: Principles and Practice of Oncology.

1988 • 1,907 citations

Clinical Pharmacology of 5-Fluorouracil

1989 • 910 citations

Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile.

1987 • 720 citations

Cancer Chemotherapy: Principles and Practice

1990 • 568 citations

Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity.

1988 • 500 citations

Interaction of pyrophosphate moieties with .alpha.-helixes in dinucleotide-binding proteins

1985 • 475 citations

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion.

1990 • 443 citations

The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13).

1986 • 371 citations

Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes

1982 • 292 citations

Familial Pyrimidinemia and Pyrimidinuria Associated with Severe Fluorouracil Toxicity

1985 • 254 citations

Rubredoxin reductase of Pseudomonas oleovorans

1990 • 245 citations

Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients.

1992 • 233 citations

Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome

1991 • 225 citations

cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver

1989 • 159 citations

Purification and characterization of dihydropyrimidine dehydrogenase from human liver.

1992 • 142 citations

Degradation of pyrimidines and pyrimidine analogs—Pathways and mutual influences

1980 • 117 citations

Purification and properties of dihydrothymine dehydrogenase from rat liver.

1981 • 102 citations

Elevated urine, blood and cerebrospinal fluid levels of uracil and thymine in a child with dihydrothymine dehydrogenase deficiency

1984 • 102 citations

Localization of human variable and constant region immunoglobulin heavy chain genes on subtelomeric band q32 of chromosome 14

1982 • 101 citations

Localization of the normal allele of T24 human bladder carcinoma oncogene to chromosome 11

1982 • 101 citations

Dihydropyrimidine dehydrogenase deficiency leading to thymine-uraciluria. An inborn error of pyrimidine metabolism

1984 • 98 citations

A homolog of a nuclear-coded iron-sulfur protein subunit of bovine mitochondrial complex I is encoded in chloroplast genomes

1991 • 95 citations

Pharmacokinetics and pharmacodynamics of locoregional 5 fluorouracil (5FU) in advanced colorectal liver metastases

1988 • 72 citations

Application of simple chromatographic methods for the diagnosis of defects in pyrimidine degradation

1993 • 60 citations

Severe Fluorouracil Toxicity in a Patient With Dihydropyrimidine Dehydrogenase Deficiency

1993 • 59 citations

Dihydropyrimidinuria: a new inborn error of pyrimidine metabolism

1991 • 52 citations

Purification and characterization of dihydropyrimidine dehydrogenase from pig liver

1989 • 52 citations

Kinetic mechanism of dihydropyrimidine dehydrogenase from pig liver.

1990 • 48 citations

Inactivation of dihydropyrimidine dehydrogenase by 5-iodouracil.

1991 • 41 citations

Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5-fluorouracil against adenocarcinoma 755 in mice

1988 • 33 citations

A new case of dihydropyrimidine dehydrogenase deficiency

1989 • 30 citations

New Defects of Pyrimidine Metabolism

1984 • 26 citations

Dihydropyrimidine dehydrogenase deficiency — A further case

1985 • 25 citations

Comparative Study of Thymine and Uracil Metabolism in Healthy Persons and in a Patient with Dihydropyrimidine Dehydrogenase Deficiency

1989 • 25 citations

Acid base catalytic mechanism of the dihydropyrimidine dehydrogenase from pH studies.

1993 • 24 citations

Effect of vitamin B2 deficiency on rat liver dihydropyrimidine dehydrogenase activity.

1991 • 23 citations