Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system 11In collaboration with The American Physiological Society, Thomas E. Andreoli, MD, Editor

Handbook of Physiology.

1960 • 10,428 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth

1993 • 2,484 citations

Insulin Resistance in Essential Hypertension

1987 • 2,386 citations

Pathogenesis of NIDDM: A Balanced Overview

1992 • 2,111 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome

1989 • 1,858 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Insulin Resistance and Insulin Secretory Dysfunction as Precursors of Non-Insulin-Dependent Diabetes Mellitus: Prospective Studies of Pima Indians

1993 • 1,516 citations

Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.

1985 • 1,485 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Pathophysiology of insulin resistance in human disease

1995 • 1,239 citations

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

1990 • 1,226 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Protein kinase activity associated with the avian sarcoma virus src gene product.

1978 • 1,137 citations

The Syndromes of Insulin Resistance and Acanthosis Nigricans

1976 • 1,086 citations

Slow Glucose Removal Rate and Hyperinsulinemia Precede the Development of Type II Diabetes in the Offspring of Diabetic Parents

1990 • 1,051 citations

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance.

1990 • 938 citations

Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome

1992 • 908 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Insulin Action and the Insulin Signaling Network*

1995 • 823 citations

Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinction

1978 • 784 citations

Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man.

1987 • 772 citations

The diversity of Rab proteins in vesicle transport

1997 • 762 citations

Decreases in Ovarian Cytochrome P450c17α Activity and Serum Free Testosterone after Reduction of Insulin Secretion in Polycystic Ovary Syndrome

1996 • 745 citations

Diabetes and Cardiovascular Disease: The “Common Soil” Hypothesis

1995 • 673 citations

Specificity and regulation of a synaptic vesicle docking complex

1994 • 601 citations

A Molecular Basis for Insulin Resistance

1997 • 550 citations

Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome.

1995 • 549 citations

The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome.

1996 • 538 citations

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

1995 • 524 citations

Polycystic Ovary Syndrome as a Form of FunctionalOvarian Hyperandrogenism Due to Dysregulation ofAndrogen Secretion*

1995 • 508 citations

Troglitazone Improves Defects in Insulin Action, Insulin Secretion, Ovarian Steroidogenesis, and Fibrinolysis in Women with Polycystic Ovary Syndrome¹

1997 • 463 citations

The Gonadotropic Function of Insulin*

1987 • 454 citations

Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance.

1998 • 450 citations

DIABETES MELLITUS

1936 • 445 citations

Tumor Necrosis Factor α-induced Phosphorylation of Insulin Receptor Substrate-1 (IRS-1)

1995 • 426 citations

Insulin Receptor: Evidence That It Is a Protein Kinase

1983 • 413 citations

Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion

1995 • 386 citations

A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family

1997 • 381 citations

The 60-kDa Phosphotyrosine Protein in Insulin-treated Adipocytes Is a New Member of the Insulin Receptor Substrate Family

1997 • 354 citations

The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism

1988 • 343 citations

Correlation between muscle glycogen synthase activity and in vivo insulin action in man.

1984 • 340 citations

Plasma Insulin Concentrations in Nondiabetic and Early Diabetic Subjects: Determinations by a New Sensitive Immuno-assay Technic

1960 • 323 citations

Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.

1997 • 314 citations

Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity.

1991 • 311 citations

Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles

1997 • 301 citations

Insulin transport across capillaries is rate limiting for insulin action in dogs.

1989 • 299 citations

An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.

1988 • 292 citations

Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: A common endocrinopathy with distinct pathophysiologic features

1983 • 291 citations

Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity

1998 • 281 citations

Gene Expression of GLUT4 in Skeletal Muscle From Insulin-Resistant Patients With Obesity, IGT, GDM, and NIDDM

1992 • 276 citations

Insulin Increases the Association of Akt-2 with Glut4-containing Vesicles

1998 • 242 citations

Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity.

1995 • 239 citations

The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle.

1996 • 226 citations

From receptor to transporter: insulin signalling to glucose transport

1997 • 211 citations

Suppression of Hyperandrogenism Does not Improve Peripheral or Hepatic Insulin Resistance in the Polycystic Ovary Syndrome*

1990 • 199 citations

Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.

1988 • 195 citations

Excess Insulin Binding to Insulin-Like Growth Factor Receptors: Proposed Mechanism for Acanthosis Nigricans

1992 • 190 citations

Insulin Receptor: Structure and Function

1981 • 187 citations

A structurally abnormal insulin causing human diabetes

1979 • 180 citations

Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation.

1992 • 180 citations

Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes. A new mechanism of insulin resistance.

1987 • 180 citations

gp160, a tissue-specific marker for insulin-activated glucose transport.

1994 • 167 citations

Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes.

1993 • 152 citations

Multiple Defects in the Adipocyte Glucose Transport System Cause Cellular Insulin Resistance in Gestational Diabetes: Heterogeneity in the Number and a Novel Abnormality in Subcellular Localization of GLUT4 Glucose Transporters

1993 • 129 citations

Maturity-onset diabetes of the young

1994 • 121 citations

Insulin Resistance Caused by Massive Degradation of Subcutaneous Insulin

1979 • 115 citations

Compartmentalization of protein traffic in insulin-sensitive cells

1996 • 108 citations

Mechanisms of enhanced insulin sensitivity in endurance-trained athletes: effects on blood flow and differential expression of GLUT 4 in skeletal muscles.

1995 • 106 citations

Diabetes Mellitus: Its differentiation into insulin-sensitive and insulin-insensitive types

2013 • 105 citations

Immunocytochemical Evidence that GLUT4 Resides in a Specialized Translocation Post-endosomal VAMP2-positive Compartment in Rat Adipose Cells in the Absence of Insulin

1997 • 101 citations

Transmembrane signaling by the human insulin receptor kinase. Relationship between intramolecular beta subunit trans- and cis-autophosphorylation and substrate kinase activation.

1992 • 98 citations

Molecular Actions of Insulin on Glucose Transport

1995 • 98 citations

Familial Hyperproinsulinemia

1976 • 97 citations

Cellular Insulin Resistance in Adipocytes from Obese Polycystic Ovary Syndrome Subjects Involves Adenosine Modulation of Insulin Sensitivity¹

1997 • 93 citations

Skeletal muscle is a primary site of insulin resistance in essential hypertension

1991 • 86 citations

No accumulation of glucose in human skeletal muscle during euglycemic hyperinsulinemia

1988 • 85 citations

Troglitazone Improves Defects in Insulin Action, Insulin Secretion, Ovarian Steroidogenesis, and Fibrinolysis in Women With Polycystic Ovary Syndrome

1998 • 83 citations

Ototoxicity of erythromycin in peritoneal dialysis patients.

1981 • 81 citations

Reversal by L-arginine of a dysfunctional arginine/nitric oxide pathway in the endothelium of the genetic diabetic BB rat

1997 • 77 citations

Binding properties of chimeric insulin receptors containing the cysteine-rich domain of either the insulin-like growth factor I receptor or the insulin receptor related receptor

1991 • 76 citations

Activation of Protein Kinase Cα Inhibits Signaling by Members of the Insulin Receptor Family

1995 • 74 citations

Insulin Resistance in Secondary Hypertension

1992 • 74 citations

Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes.

1994 • 73 citations

Identification and characterization of two distinct intracellular GLUT4 pools in rat skeletal muscle: evidence for an endosomal and an insulin-sensitive GLUT4 compartment

1997 • 72 citations

Hyperinsulinemia and hyperandrogenemia: in vivo androgen response to insulin infusion.

1987 • 70 citations

Insulin second messengers

1997 • 69 citations

Molecular Biology of Diabetes

1994 • 69 citations

Cellular Insulin Resistance in Adipocytes from Obese Polycystic Ovary Syndrome Subjects Involves Adenosine Modulation of Insulin Sensitivity

1997 • 65 citations

1 Cellular insulin action and insulin resistance

1993 • 65 citations

INSULIN RESISTANCE: CLINICAL FEATURES, NATURAL COURSE AND EFFECTS OF ADRENAL STEROID TREATMENT.

1965 • 63 citations

INSULIN RESISTANCE

1965 • 56 citations

Mutant insulin receptors in syndromes of insulin resistance

1992 • 53 citations

Immunologic Insulin Resistance

1978 • 50 citations

Structure and Function of Insulin Receptors

1989 • 48 citations

Molecular Machinery Mediating Vesicle Budding, Docking and Fusion.

1996 • 45 citations

Advances in Endocrinology and Metabolism

1991 • 39 citations

In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studies.

1991 • 35 citations

The Effects of Brefeldin A on the Glucose Transport System in Rat Adipocytes

1995 • 29 citations

Trafficking, targeting and translocation of the insulin-responsive glucose transporter, GLUT4, in adipocytes

1996 • 12 citations