CYCLOOXYGENASE-2 INHIBITORS

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

1994 • 1,579 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics

1991 • 1,330 citations

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

1994 • 1,322 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

Misoprostol Reduces Serious Gastrointestinal Complications in Patients with Rheumatoid Arthritis Receiving Nonsteroidal Anti-Inflammatory Drugs

1995 • 1,071 citations

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

1990 • 940 citations

Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.

1994 • 862 citations

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

1994 • 826 citations

Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

1994 • 661 citations

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

1991 • 571 citations

Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase.

1992 • 498 citations

Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme.

1992 • 471 citations

Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase

1995 • 414 citations

Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase.

1994 • 410 citations

Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice.

1990 • 404 citations

NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions

1993 • 348 citations

Regulation of prostaglandin synthase-1 and prostaglandin synthase-2

1994 • 337 citations

Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles.

1992 • 312 citations

Duodenal and Gastric Ulcer Prevention with Misoprostol in Arthritis Patients Taking NSAIDs

1993 • 300 citations

Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2.

1993 • 293 citations

Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases.

1989 • 235 citations

Nonsteroidal Anti-inflammatory Drug Gastropathy

1987 • 192 citations

From experiment to experience: Side effects of nonsteroidal anti-inflammatory drugs

1983 • 127 citations

In vivo glucocorticoids regulate cyclooxygenase-2 but not cyclooxygenase-1 in peritoneal macrophages.

1994 • 125 citations

Plasma Concentrations, Renal Excretion, and Tissue Release of Prostaglandins in the Rat with Dexamethasone-Induced Hypertension^*

1984 • 59 citations

Effect of dexamethasone on in vivo prostanoid production in the rabbit.

1984 • 54 citations

THE GASTRODUODENAL SAFETY AND EFFICACY OF THE FIXED COMBINATION OF DICLOFENAC AND MISOPROSTOL IN THE TREATMENT OF OSTEOARTHRITIS

1992 • 43 citations

Nonsteroidal anti-inflammatory drug gastropathy. Recognition and response

1987 • 27 citations

Actions and toxic effects of the nonsteroidal anti-inflammatory drugs

1994 • 24 citations

The Safety of Arthrotec® in Patients with Rheumatoid Arthritis or Osteoarthritis: An Assessment of the Upper Gastrointestinal Tract by Endoscopy

1992 • 13 citations

Metabolite Measurement as an Index of Prostaglandin Synthesis in Vivo

1980 • 6 citations