Radiation and stress-induced apoptosis: A role for Fas/Fas ligand interactions

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

Fas ligation induces apoptosis of CD40-activated human B lymphocytes.

1995 • 402 citations

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

1995 • 323 citations

Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL-4.

1993 • 214 citations

The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr.

1993 • 210 citations

An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity.

1991 • 198 citations

Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells

1993 • 146 citations

Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis.

1993 • 125 citations

Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice.

1993 • 125 citations

Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis.

1996 • 117 citations

APOPTOSIS AND THE IMMUNE RESPONSE

1996 • 66 citations

Apoptosis abnormalities of splenic lymphocytes in autoimmune lpr and gld mice.

1995 • 59 citations

Role of DNA fragmentation in T cell activation-induced apoptosis in vitro and in vivo.

1994 • 55 citations

Expression and function of the murine CD95/FasR/APO‐1 receptor in relation to B cell ontogeny

1995 • 49 citations

Phenotypic Abnormalities of Splenic and Bone Marrow B Cells inlprandgldMice

1996 • 24 citations

Radiation-induced apoptosis is differentially regulated in primary B cells from normal mice and mice with the CBA/N X-linked immunodeficiency.

1995 • 17 citations