Bone Marrow Transplantation for Non-Malignant Disease

Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease

2000 • 2,632 citations

Sickle Cell Anemia, a Molecular Disease

1949 • 2,216 citations

Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia

1995 • 2,210 citations

Nonmyeloablative Stem Cell Transplantation and Cell Therapy as an Alternative to Conventional Bone Marrow Transplantation With Lethal Cytoreduction for the Treatment of Malignant and Nonmalignant Hematologic Diseases

1998 • 1,984 citations

Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta

1999 • 1,841 citations

Epidemiology and Estimated Population Burden of Selected Autoimmune Diseases in the United States

1997 • 1,628 citations

Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis

1999 • 1,212 citations

Etanercept in Children with Polyarticular Juvenile Rheumatoid Arthritis

2000 • 1,211 citations

Placental Blood as a Source of Hematopoietic Stem Cells for Transplantation into Unrelated Recipients

1996 • 1,053 citations

IMMUNOLOGICAL RECONSTITUTION OF SEX-LINKED LYMPHOPENIC IMMUNOLOGICAL DEFICIENCY

1968 • 1,011 citations

Transplant-lite: induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies.

1998 • 967 citations

Gene Mutations in Human Hæmoglobin: the Chemical Difference Between Normal and Sickle Cell Hæmoglobin

1957 • 938 citations

Survival in Medically Treated Patients with Homozygous β-Thalassemia

1994 • 874 citations

BONE-MARROW TRANSPLANTATION IN A PATIENT WITH THE WISKOTT-ALDRICH SYNDROME

1968 • 873 citations

Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA ⁻ Immunodeficient Patients

1995 • 846 citations

Efficacy of Deferoxamine in Preventing Complications of Iron Overload in Patients with Thalassemia Major

1994 • 832 citations

Defining criteria for autoimmune diseases (Witebsky's postulates revisited)

1993 • 781 citations

Hematopoietic Stem-Cell Transplantation for the Treatment of Severe Combined Immunodeficiency

1999 • 713 citations

Systemic Lupus Erythematosus

1996 • 677 citations

Stable Mixed Hematopoietic Chimerism in DLA-Identical Littermate Dogs Given Sublethal Total Body Irradiation Before and Pharmacological Immunosuppression After Marrow Transplantation

1997 • 633 citations

Bone Marrow Transplantation in Patients with Thalassemia

1990 • 632 citations

Engraftment of gene–modified umbilical cord blood cells in neonates with adenosine deaminase deficiency

1995 • 622 citations

Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease

1995 • 607 citations

Bone Marrow Transplantation for Sickle Cell Disease

1996 • 603 citations

Microchimerism and HLA-compatible relationships of pregnancy in scleroderma

1998 • 600 citations

Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability

1998 • 504 citations

Prediction of Adverse Outcomes in Children with Sickle Cell Disease

2000 • 501 citations

Transplantation for severe combined immunodeficiency with HLA-A,B,D,DR incompatible parental marrow cells fractionated by soybean agglutinin and sheep red blood cells

1983 • 497 citations

Autoimmune Diseases: The Failure of Self Tolerance

1990 • 495 citations

REVERSAL OF CLINICAL FEATURES OF HURLER'S DISEASE AND BIOCHEMICAL IMPROVEMENT AFTER TREATMENT BY BONE-MARROW TRANSPLANTATION

1981 • 490 citations

Thalassemia Syndromes

2009 • 476 citations

Chronic Enteroviral Meningoencephalitis in Agammaglobulinemic Patients

1987 • 458 citations

Successful Bone-Marrow Transplantation for Infantile Malignant Osteopetrosis

1980 • 449 citations

Safety of Hydroxyurea in Children With Sickle Cell Anemia: Results of the HUG-KIDS Study, a Phase I/II Trial

1999 • 417 citations

Mixed lymphohaemopoietic chimerism and graft-ver suslymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation

1999 • 405 citations

Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report

2000 • 359 citations

Reversal of Early Neurologic and Neuroradiologic Manifestations of X-Linked Adrenoleukodystrophy by Bone Marrow Transplantation

1990 • 344 citations

T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates

1998 • 334 citations

MARROW TRANSPLANTATION FOR THALASSAEMIA

1982 • 330 citations

Taking mortality in rheumatoid arthritis seriously--predictive markers, socioeconomic status and comorbidity.

1986 • 328 citations

Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning

1997 • 317 citations

Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia

2001 • 316 citations

Haematopoietic stem cell transplantation for sickle cell anaemia: the first 50 patients transplanted in Belgium

1998 • 313 citations

Bone-Marrow Transplantation in a Patient with Sickle-Cell Anemia

1984 • 306 citations

Immune reconstitution following bone marrow transplantation: comparison of recipients of T-cell depleted marrow with recipients of conventional marrow grafts

1989 • 261 citations

Complete Correction of the Wiskott-Aldrich Syndrome by Allogeneic Bone-Marrow Transplantation

1978 • 256 citations

Blood and marrow stem cell transsplants in auto-immune disease: a consensus report written on behalf of the European League against Rheumatism (EULAR) and the European Group for Blood and Marrow Transplantation (EBMT)

1997 • 247 citations

Treatment of severe systemic lupus erythematosus with high-dose chemotherapy and haemopoietic stem-cell transplantation: a phase I study

2000 • 245 citations

Rationale for bone marrow transplantation in the treatment of autoimmune diseases.

1985 • 244 citations

Risk factors for ovarian failure in patients with systemic lupus erythematosus receiving cyclophosphamide therapy

1998 • 241 citations

Immunoablative High-Dose Cyclophosphamide without Stem-Cell Rescue for Refractory, Severe Autoimmune Disease

1998 • 236 citations

Long‐term survival in systemic lupus erythematosus patient characteristics associated with poorer outcomes

1995 • 236 citations

Course of Crohn's disease after allogeneic marrow transplantation

1998 • 228 citations

Mini-allografts: ongoing trials in humans

2000 • 226 citations

Marrow transplantation for patients with thalassemia: results in class 3 patients

1996 • 219 citations

Willingness to pay and accept risks to cure chronic disease.

1986 • 211 citations

Early recurrence or persistence of autoimmune diseases after unmanipulated autologous stem cell transplantation

1996 • 211 citations

Treatment of Autoimmune Disease by Intense Immunosuppressive Conditioning and Autologous Hematopoietic Stem Cell Transplantation

1998 • 208 citations

Juvenile chronic arthritis into adulthood: a long‐term follow‐up study

2000 • 207 citations

Bone-Marrow Transplantation in the Maroteaux–Lamy Syndrome (Mucopolysaccharidosis Type VI)

1984 • 203 citations

BONE-MARROW TRANSPLANTATION FOR IMMUNODEFICIENCIES AND OSTEOPETROSIS: EUROPEAN SURVEY, 1968-1985

1986 • 201 citations

Autologous haemopoietic stem-cell transplantation in four patients with refractory juvenile chronic arthritis

1999 • 196 citations

Long-term survival of ex-thalassemic patients with persistent mixed chimerism after bone marrow transplantation

2000 • 189 citations

Mixed chimerism: Preclinical studies and clinical applications

1999 • 188 citations

Reconstitution in Severe Combined Immunodeficiency by Transplantation of Marrow from an Unrelated Donor

1977 • 186 citations

Bone marrow gene transfer in three patients with adenosine deaminase deficiency.

1996 • 185 citations

Bone Marrow Transplantation in Adult Thalassemic Patients

1999 • 185 citations

Barriers to bone marrow transplantation for sickle cell anemia.

1996 • 181 citations

Persistence of mixed chimerism in patients transplanted for the treatment of thalassemia

1996 • 177 citations

Autologous haematopoietic stem cell transplants for autoimmune disease – feasibility and transplant-related mortality

1999 • 174 citations

A survival study of patients with scleroderma diagnosed over 30 years (1953-1983): the value of a simple cutaneous classification in the early stages of the disease.

1988 • 171 citations

Autologous stem cell transplantation in progressive multiple sclerosis--an interim analysis of efficacy.

2000 • 168 citations

Phlebotomy to Reduce Iron Overload in Patients Cured of Thalassemia by Bone Marrow Transplantation

1997 • 153 citations

MIXED CHIMERISM AS AN APPROACH FOR THE INDUCTION OF TRANSPLANTATION TOLERANCE1

1999 • 150 citations

Pre-existing autoimmune disease in patients with long-term survival after allogeneic bone marrow transplantation.

1997 • 149 citations

Neurologic complications after allogeneic marrow transplantation for sickle cell anemia [see comments]

1995 • 146 citations

STERILITY AND CYCLOPHOSPHAMIDE

1972 • 145 citations

Bone-Marrow Transplantation in Severe Gaucher's Disease

1984 • 138 citations

Lupus Nephritis: Prognostic Factors in Children

1992 • 136 citations

Intermittent intravenous cyclophosphamide arrests progression of the renal chronicity index in childhood systemic lupus erythematosus

2000 • 134 citations

Bone marrow transplantation from alternative donors for thalassemia: HLA-phenotypically identical relative and HLA-nonidentical sibling or parent transplants

2000 • 131 citations

The use of HLA-non-identical T-cell-depleted marrow transplants for correction of severe combined immunodeficiency disease.

1989 • 131 citations

Progression of rheumatoid arthritis following bone marrow transplantation. A case report with a 13‐year followup

1996 • 127 citations

Bone Marrow Transplantation in Thalassemia: The Experience of Pesaro

1998 • 125 citations

Bone Marrow Transplantation in Thalassemia

1991 • 124 citations

Prevention and reversal of adoptively transferred, chronic relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation.

1993 • 123 citations

Influence of severe combined immunodeficiency phenotype on the outcome of HLA non-identical, T-cell–depleted bone marrow transplantationA retrospective European survey from the European Group for Bone Marrow Transplantation and the European Society for Immunodeficiency

1999 • 120 citations

Regression of adjuvant-induced arthritis in rats following bone marrow transplantation.

1989 • 120 citations

Reversal of clinical features of hurler's disease and biochemical improvement after treatment by bone marrow transplantation

1982 • 119 citations

T cell-depleted autologous hematopoietic stem cell transplantation for multiple sclerosis: report on the first three patients

1998 • 116 citations

Availability of related donors for bone marrow transplantation in sickle cell anemia.

1994 • 115 citations

Lupus: Key Pathogenic Mechanisms and Contributing Factors

1995 • 112 citations

The use of methotrexate in childhood rheumatic diseases

1998 • 109 citations

LONG-TERM FOLLOW-UP OF THE FIRST SUCCESSFUL BONE MARROW TRANSPLANTATION IN GAUCHER DISEASE

1988 • 108 citations

Bone Marrow Transplantation in Patients with Gold‐Induced Marrow Aplasia

1977 • 105 citations

New Horizons in the Treatment of Autoimmune Diseases: Immunoablation and Stem Cell Transplantation

2000 • 104 citations

Allogeneic bone marrow transplant for chronic myelogenous leukemia in a patient with multiple sclerosis

1997 • 99 citations

Bone marrow transplantation in 26 patients with Wiskott-Aldrich syndrome from a single center

1996 • 97 citations

Commentary on and reprint of Gatti RA, Allen HD, Meuwissen HJ, Hong R, Good RA, Immunological reconstitution of sex-linked lymphopenic deficiency, in Lancet (1968) 2:1366–1369

2000 • 96 citations

Successful Correction of Hemophagocytic Lymphohistiocytosis With Related or Unrelated Bone Marrow Transplantation

1997 • 92 citations

Stem cell transplantation in experimental models of autoimmune disease.

2000 • 92 citations

Fate of iron stores in thalassaemia after bone-marrow transplantation

1993 • 90 citations

A phase I/II dose escalation study of intensified cyclophosphamide and autologous blood stem cell rescue in severe, active rheumatoid arthritis

1999 • 89 citations

Autologous hematopoietic stem cell transplantation in refractory rheumatoid arthritis: Sustained response in two of four patients

1999 • 84 citations

Marked and sustained improvement two years after autologous stem cell transplantation in a girl with systemic sclerosis

1999 • 84 citations

BONE-MARROW TRANSPLANTATION FOR METACHROMATIC LEUCODYSTROPHY

1985 • 82 citations

Hypothesis for the pathogenesis of systemic sclerosis.

1997 • 80 citations

Bone-Marrow Transplantation in Sickle-Cell Disease

1997 • 79 citations

Outcome of Cord-Blood Transplantation From Related and Unrelated Donors

1998 • 77 citations

Scleroderma--demographics and survival.

1997 • 72 citations

Systemic lupus erythematosus: demographics, prognosis, and outcome.

1997 • 64 citations

BONE MARROW TRANSPLANTATION FOR BETA-THALASSEMIA

1999 • 63 citations

Severity, pathobiology, epistatic effects, and genetic markers in sickle cell anemia.

1991 • 61 citations

Donor Lymphocyte Infusions to Displace Residual Host Hematopoietic Cells after Allogeneic Bone Marrow Transplantation for β-Thalassemia Major

1998 • 59 citations

Autoimmune diseases as stem cell disorders: normal stem cell transplant for their treatment (Review).

1998 • 57 citations

Persistence of fetal hemoglobin production after successful transplantation of cord blood stem cells in a patient with sickle cell anemia

1996 • 57 citations

Mixed Hematopoietic Chimerism after Marrow Allografts Transplantation in the Ambulatory Care Setting

1999 • 56 citations

Bone marrow transplantation corrects the splenic reticuloendothelial dysfunction in sickle cell anemia

1993 • 54 citations

Bone marrow transplantation in thalassemia: modifications of hepatic iron overload and associated lesions after long‐term engrafting

1994 • 50 citations

High-Dose Chemotherapy and Syngeneic Hemopoietic Stem-Cell Transplantation for Severe, Seronegative Rheumatoid Arthritis

1999 • 49 citations

Management of Sickle Cell Disease

2000 • 48 citations

Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions.

1997 • 46 citations

Bone marrow transplantation for storage diseases.

1991 • 42 citations

Bone Marrow Transplantation for Sickle Cell Disease

1999 • 42 citations

Growth and endocrine function following bone marrow transplantation for thalassemia.

1995 • 37 citations

Current and Future Preparative Regimens for Bone Marrow Transplantation in Thalassemia^a

1998 • 36 citations

Intensified-dose (4 gm/m2) cyclophosphamide and granulocyte colony-stimulating factor administration for hematopoietic stem cell mobilization in refractory rheumatoid arthritis

1999 • 35 citations

BMT beats autoimmune disease

1998 • 35 citations

Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability. 1998 [classical article].

2001 • 35 citations

Side-effects of long-term immunosuppression versus morbidity in autologous stem cell rescue: striking the balance

1999 • 34 citations

Bone marrow transplantation for sickle cell disease. The United States experience.

1994 • 34 citations

The evolving role of blood and marrow transplantation for the treatment of autoimmune diseases.

1997 • 33 citations

Bone marrow transplantation in a young child with sickle cell anemia

1995 • 31 citations

Effectiveness and risks of total body irradiation for conditioning in the treatment of autoimmune disease with autologous bone marrow transplantation

1999 • 31 citations

FOR DEBATE: BONE MARROW TRANSPLANTATION FOR SEVERE THALASSAEMIA (1) THE VIEW FROM PESARO

1991 • 30 citations

[Results and current indications of bone marrow allograft in sickle cell disease].

1999 • 29 citations

Hematopoietic Stem Cell Transplantation: A New Therapy for Autoimmune Disease

1999 • 29 citations

Choosing appropriate patients with systemic sclerosis for treatment by autologous stem cell transplantation.

1997 • 28 citations

Neurologic complications following bone marrow transplantation for sickle cell disease.

1996 • 28 citations

CORD BLOOD TRANSPLANTATION (CBT) IN HEMOGLOBINOPATHIES

1998 • 26 citations

Preclinical investigations that subserve efforts to employ bone marrow transplantation for rheumatoid or autoimmune diseases.

1997 • 26 citations

Bone marrow transplantation for hemoglobinopathies

2000 • 26 citations

Autologous stem cell transplantation for autoimmune diseases: issues in protocol development.

1997 • 25 citations

Bone marrow transplantation for thalassemia

1993 • 25 citations

Growth in children after bone marrow transplantation for thalassemia.

1993 • 25 citations

Successful unrelated bone marrow transplantation in beta-thalassaemia.

1994 • 24 citations

Cord blood transplantation (CBT) in hemoglobinopathies. Eurocord.

1998 • 22 citations

Gene-marked autologous hematopoietic stem cell transplantation of autoimmune disease.

2000 • 22 citations

Longterm followup and quality of life after hematopoietic stem cell transplantation.

1997 • 22 citations

The Biology of Bone Marrow Transplantation for Severe Combined Immune Deficiency

1991 • 21 citations

Neurologic complications after bone marrow transplantation for sickle cell anemia [letter; comment]

1995 • 21 citations

Bone marrow transplantation in sickle-cell anemia in Pesaro.

1993 • 21 citations

Coexistence of Two Functioning T-Cell Repertoires in Healthy Ex-Thalassemics Bearing a Persistent Mixed Chimerism Years After Bone Marrow Transplantation

1999 • 20 citations

Bone marrow transplantation for immunodeficiencies and osteopetrosis.

1991 • 20 citations

An unusual marrow transplant complication: cardiac myxoma

1998 • 18 citations

Pros and cons of stem cell transplantation for autoimmune disease.

1997 • 17 citations

Influence of the conditioning regimens on the incidence of mixed chimerism in thalassemic transplanted patients.

1993 • 17 citations

Collaborative study of marrow transplantation for sickle cell disease: Aspects specific for transplantation of hemoglobin disorders

1997 • 16 citations

Rationale for high-dose cyclophosphamide and medium-dose total body irradiation in the conditioning of children with progressive systemic and polyarticular juvenile chronic arthritis before autologous stem cell transplantation

1999 • 13 citations

Bone marrow transplantation for sickle cell anemia.

1994 • 13 citations

Sickle cell diseases in the 1990s: the need for active and preventive intervention.

1991 • 13 citations

Development of a protocol for allogeneic marrow transplantation for severe systemic sclerosis: paradigm for autoimmune disease.

1997 • 13 citations

The potential role of autologous stem cell transplantation in patients with systemic lupus erythematosus.

1997 • 9 citations

Gonadal function in long term survivors with B thalassemia major following bone marrow transplantation.

1993 • 8 citations

A preliminary definition of the term ?cure? as applied to systemic lupus erythematosus

1999 • 7 citations

Recent advances in the management of thalassemia

1995 • 6 citations