The oligomeric conformation of peroxiredoxins links redox state to function

Structure, mechanism and regulation of peroxiredoxins

2003 • 2,454 citations

Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling

2003 • 1,317 citations

ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

2003 • 926 citations

Two Enzymes in One

2004 • 729 citations

The function of peroxiredoxins in plant organelle redox metabolism

2006 • 420 citations

Crystal structure of a novel human peroxidase enzyme at 2.0 Å resolution

1998 • 370 citations

S-Nitrosylation of Peroxiredoxin II E Promotes Peroxynitrite-Mediated Tyrosine Nitration

2007 • 341 citations

Dimers to Doughnuts: Redox-Sensitive Oligomerization of 2-Cysteine Peroxiredoxins^,

2002 • 337 citations

Rice NTRC Is a High-Efficiency Redox System for Chloroplast Protection against Oxidative Damage

2006 • 314 citations

The plant-specific function of 2-Cys peroxiredoxin-mediated detoxification of peroxides in the redox-hierarchy of photosynthetic electron flux

2002 • 298 citations

Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7Å resolution

2000 • 296 citations

Oxidative Stress-dependent Structural and Functional Switching of a Human 2-Cys Peroxiredoxin Isotype II That Enhances HeLa Cell Resistance to H2O2-induced Cell Death

2005 • 293 citations

Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product

1999 • 255 citations

Regulation of Peroxiredoxin I Activity by Cdc2-mediated Phosphorylation

2002 • 241 citations

Protective Function of Chloroplast 2-Cysteine Peroxiredoxin in Photosynthesis. Evidence from Transgenic Arabidopsis1

1999 • 213 citations

Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C

2007 • 209 citations

Analysis of the Link between Enzymatic Activity and Oligomeric State in AhpC, a Bacterial Peroxiredoxin^,

2005 • 196 citations

Reaction Mechanism of Plant 2-Cys Peroxiredoxin

2003 • 177 citations

Irreversible Oxidation of the Active-site Cysteine of Peroxiredoxin to Cysteine Sulfonic Acid for Enhanced Molecular Chaperone Activity

2008 • 172 citations

The Structure of Reduced Tryparedoxin Peroxidase Reveals a Decamer and Insight into Reactivity of 2Cys-peroxiredoxins

2000 • 154 citations

Catalytic Mechanism of Thiol Peroxidase from Escherichia coli

2003 • 153 citations

Human Peroxiredoxin 1 and 2 Are Not Duplicate Proteins

2007 • 149 citations

The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function

2006 • 140 citations

Phosphorylation and concomitant structural changes in human 2‐Cys peroxiredoxin isotype I differentially regulate its peroxidase and molecular chaperone functions

2005 • 127 citations

Biomimetic magnetic nanoparticles

2005 • 108 citations

Bovine Mitochondrial Peroxiredoxin III Forms a Two-Ring Catenane

2005 • 106 citations

Regulation of Thioredoxin Peroxidase Activity by C-terminal Truncation

2002 • 103 citations

Primary structure and expression of plant homologues of animal and fungal thioredoxin-dependent peroxide reductases and bacterial alkyl hydroperoxide reductases

1996 • 98 citations

Structure and Mechanism of the Alkyl Hydroperoxidase AhpC, a Key Elementof the Mycobacterium tuberculosis Defense System against OxidativeStress

2005 • 95 citations

Structural Survey of the Peroxiredoxins

2007 • 95 citations

Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys Peroxiredoxin

2005 • 81 citations

Crystal Structure of a Dimeric Oxidized form of Human Peroxiredoxin 5

2004 • 80 citations

Interaction of Surfactant Protein A with Peroxiredoxin 6 Regulates Phospholipase A2 Activity

2005 • 79 citations

Reconstitution of the Mitochondrial PrxIII Antioxidant Defence Pathway: General Properties and Factors Affecting PrxIII Activity and Oligomeric State

2007 • 76 citations

Thermodynamics of the Dimer−Decamer Transition of Reduced Human and Plant 2-Cys Peroxiredoxin

2008 • 75 citations

Dimer-Oligomer Interconversion of Wild-type and Mutant Rat 2-Cys Peroxiredoxin

2007 • 68 citations

Glutathionylation Induces the Dissociation of 1-Cys D-peroxiredoxin Non-covalent Homodimer

2006 • 66 citations

Hexameric oligomerization of mitochondrial peroxiredoxin PrxIIF and formation of an ultrahigh affinity complex with its electron donor thioredoxin Trx-o

2008 • 65 citations

Crystal Structure of Escherichia coli Thiol Peroxidase in the Oxidized State

2003 • 64 citations

The Tetrameric Structure of Haemophilus influenzaHybrid Prx5 Reveals Interactions between Electron Donor and Acceptor Proteins

2003 • 61 citations

Stimulation of Peroxidase Activity by Decamerization Related to Ionic Strength: AhpC Protein from Amphibacillus xylanus

1999 • 59 citations

Characterization of the Mycobacterium tuberculosis H37Rv alkyl hydroperoxidase AhpC points to the importance of ionic interactions in oligomerization and activity

2001 • 59 citations

Crystal Structure of an Archaeal Peroxiredoxin from the Aerobic Hyperthermophilic Crenarchaeon Aeropyrum pernix K1

2005 • 59 citations

Formation, TEM study and 3D reconstruction of the human erythrocyte peroxiredoxin-2 dodecahedral higher-order assembly

2006 • 59 citations

Cloning and characterization of a 2-Cys peroxiredoxin from Pisum sativum

2004 • 53 citations

Calcium-activated potassium transport and high molecular weight forms of calpromotin.

1992 • 52 citations

Crystal Structure and Solution NMR Dynamics of a D (Type II) Peroxiredoxin Glutaredoxin and Thioredoxin Dependent: A New Insight into the Peroxiredoxin Oligomerism

2005 • 52 citations

Characterization of the complex of glutathione S-transferase pi and 1-cysteine peroxiredoxin

2008 • 52 citations

Properties of Thiol-Specific Anti-oxidant Protein or Calpromotin in Solution

1999 • 49 citations

Regulation of peroxiredoxin expression versus expression of Halliwell-Asada-Cycle enzymes during early seedling development of Arabidopsis thaliana

2006 • 48 citations

Biochemical characterization of Toxoplasma gondii 1-Cys peroxiredoxin 2 with mechanistic similarities to typical 2-Cys Prx

2005 • 43 citations

Characterization of Novel Hexadecameric Thioredoxin Peroxidase from Aeropyrum pernix K1

2003 • 41 citations

Non-reductive modulation of chloroplast fructose-1,6-bisphosphatase by 2-Cys peroxiredoxin

2007 • 40 citations

The crystal structures of oxidized forms of human peroxiredoxin 5 with an intramolecular disulfide bond confirm the proposed enzymatic mechanism for atypical 2-Cys peroxiredoxins

2008 • 39 citations

Characterization of the Mycobacterium tuberculosis H37Rv alkyl hydroperoxidase AhpC points to the importance of ionic interactions in oligomerization and activity

2001 • 37 citations

Crystal structure of alkyl hydroperoxide-reductase (AhpC) from Helicobacter pylori

2005 • 35 citations

Oligomeric Hsp33 with Enhanced Chaperone Activity

2004 • 29 citations

Protein 7.2b of Human Erythrocyte Membranes Binds to Calpromotin

1997 • 29 citations

ATP‐dependent modulation and autophosphorylation of rapeseed 2‐Cys peroxiredoxin

2008 • 29 citations

Protein–protein interactions within peroxiredoxin systems

2006 • 27 citations

Functional characterisation of the peroxiredoxin gene family members of Synechococcus elongatus PCC 7942

2008 • 23 citations

The crystal structure of the C45S mutant of annelid Arenicola marina peroxiredoxin 6 supports its assignment to the mechanistically typical 2‐Cys subfamily without any formation of toroid‐shaped decamers

2008 • 21 citations

Cloning, overexpression, purification and preliminary crystallographic studies of a mitochondrial type II peroxiredoxin fromPisum sativum

2006 • 18 citations

Reversible conformational switch revealed by the redox structures of Bacillus subtilis thiol peroxidase

2008 • 15 citations

[Study of the quaternary structure of rat 1-Cys peroxiredoxin].

2007 • 1 citations