DETECTION OF GENE DEFECTS IN THE THALASSEMIAS AND RELATED DISORDERS*

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Nucleotide sequence of the rightward operator of phage lambda.

1975 • 2,068 citations

The isolation of structural genes from libraries of eucaryotic DNA

1978 • 1,877 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning

1977 • 951 citations

Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.

1978 • 804 citations

The rabbit β-globin gene contains a large insert in the coding sequence

1977 • 422 citations

Restriction Endonuclease

1976 • 405 citations

Insertion of synthetic copies of human globin genes into bacterial plasmids

1978 • 350 citations

Analysis of the β-δ-globin gene loci in normal and hb lepore DNA: Direct determination of gene linkage and intergene distance

1978 • 260 citations

Gene deletion as the cause of α thalassaemia: Genetic lesion in homozygous α thalassaemia (hydrops fetalis)

1974 • 227 citations

Human beta-globin messenger RNA. III. Nucleotide sequences derived from complementary DNA.

1977 • 224 citations

Gene deletion as the cause of α thalassaemia: The severe form of α thalassaemia is caused by a haemoglobin gene deletion

1974 • 220 citations

Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia.

1979 • 159 citations

Organization of human δ- and β-globin genes in cellular DNA and the presence of intragenic inserts

1978 • 141 citations

Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders

1978 • 104 citations

The thalassemia syndromes

1978 • 102 citations

The thalassemia syndromes

1978 • 98 citations

δβ-Thalassemia is due to a gene deletion

1976 • 97 citations

Absence of messenger RNA and gene DNA for β-globin chains in hereditary persistence of fetal hemoglobin

1976 • 86 citations

Abnormal or absent β mRNA in β0 Ferrara and gene deletion in δβ thalassaemia

1976 • 80 citations

Demonstration of non-functional beta-globin mRNA in homozygous beta (0) thalassemia.

1975 • 77 citations

Deletion of the β-globin structure gene in hereditary persistence of foetal haemoglobin

1975 • 75 citations

Human globin gene analysis for a patient with beta-o/delta beta-thalassemia.

1975 • 68 citations

Isolation and partial sequence of recombinant plasmids containing human α-, β- and γ-globin cDNA fragments

1978 • 67 citations

Variability in the amount of β-globin mRNA in β0 thalassemia

1978 • 63 citations

Relative numbers of human globin genes assayed with purified alpha and beta complementary human DNA.

1975 • 59 citations

A direct estimate of the number of human γ-globin genes

1976 • 53 citations

Characterization of β-globin mRNA in the β0 thalassemias

1978 • 46 citations

Quantitation of human gamma globin genes and gamma globin mRNA with purified gamma globin complementary DNA.

1976 • 12 citations

Third Conference on Cooley's Anemia.

1974 • 2 citations