Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.

1978 • 804 citations

Restriction Endonuclease

1976 • 405 citations

Insertion of synthetic copies of human globin genes into bacterial plasmids

1978 • 350 citations

THE FUSION OF TWO PEPTIDE CHAINS IN HEMOGLOBIN LEPORE AND ITS INTERPRETATION AS A GENETIC DELETION

1962 • 331 citations

Analysis of the β-δ-globin gene loci in normal and hb lepore DNA: Direct determination of gene linkage and intergene distance

1978 • 260 citations

Gene deletion as the cause of α thalassaemia: Genetic lesion in homozygous α thalassaemia (hydrops fetalis)

1974 • 227 citations

Human beta-globin messenger RNA. III. Nucleotide sequences derived from complementary DNA.

1977 • 224 citations

Gene deletion as the cause of α thalassaemia: The severe form of α thalassaemia is caused by a haemoglobin gene deletion

1974 • 220 citations

Application of Endonuclease Mapping to the Analysis and Prenatal Diagnosis of Thalassemias Caused by Globin-Gene Deletion

1978 • 207 citations

The duplicated human alpha globin genes lie close together in cellular DNA.

1978 • 177 citations

Organization of human δ- and β-globin genes in cellular DNA and the presence of intragenic inserts

1978 • 141 citations

Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders

1978 • 104 citations

δβ-Thalassemia is due to a gene deletion

1976 • 97 citations

Absence of messenger RNA and gene DNA for β-globin chains in hereditary persistence of fetal hemoglobin

1976 • 86 citations

Abnormal or absent β mRNA in β0 Ferrara and gene deletion in δβ thalassaemia

1976 • 80 citations

Deletion of the β-globin structure gene in hereditary persistence of foetal haemoglobin

1975 • 75 citations

Presence of gene for β globin in homozygous β0 thalassaemia

1976 • 66 citations

Variability in the amount of β-globin mRNA in β0 thalassemia

1978 • 63 citations

Authentic beta-globin mRNA sequences in homozygous betaO-thalassemia.

1977 • 63 citations

Characterization of β-globin mRNA in the β0 thalassemias

1978 • 46 citations

Relative stability of alpha- and beta-globin messenger RNAs in homozygous beta+ thalassemia.

1977 • 43 citations

beta-O-thalassemia from Algeria: genetic and molecular characterization

1977 • 24 citations

Selective restriction endonuclease cleavage of human globin genes.

1978 • 22 citations

Restriction endonuclease analysis of human globin genes in cellular DNA

1978 • 19 citations

Absence of beta mRNA in beta0-thalassemia in Kurdish Jews

1978 • 12 citations