Regulation of β‐tubulin function and expression in Drosophila spermatogenesis

The Genome of Drosophila Melanogaster

1992 • 3,126 citations

The Genetics and Biology of Drosophila

1976 • 1,427 citations

Tissue specificity of Drosophila P element transposition is regulated at the level of mRNA splicing

1986 • 568 citations

Sequence, structure, and codon preference of theDrosophilaribosomal protein 49 gene

1984 • 523 citations

The Role of X-Chromosome Inactivation during Spermatogenesis

1972 • 508 citations

Structure and Utilization of Tubulin Isotypes

1988 • 474 citations

Synthetic activities during spermatogenesis in the mouse

1965 • 419 citations

Evolution of Postmating Reproductive Isolation: The Composite Nature of Haldane's Rule and Its Genetic Bases

1993 • 413 citations

Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes.

1986 • 403 citations

Vectors for P-Mediated Transformation in Drosophila

1988 • 399 citations

RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos

1991 • 391 citations

[45] The use of intensifying screens or organic scintillators for visualizing radioactive molecules resolved by gel electrophoresis

1980 • 367 citations

Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.

1989 • 367 citations

The white gene as a marker in a new P-element vector for gene transfer inDrosophila

1987 • 355 citations

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

1993 • 332 citations

Development as an evolutionary process

1987 • 317 citations

Molecular biology of the cytoskeleton

1984 • 296 citations

A transposable P vector that confers selectable G418 resistance to Drosophila larvae

1985 • 286 citations

The testis-specific β-tubulin subunit in drosophila melanogaster has multiple functions in spermatogenesis

1982 • 285 citations

Involvement of the carboxyl-terminal domain of tubulin in the regulation of its assembly.

1984 • 251 citations

Nonsense mutations in the human beta-globin gene affect mRNA metabolism.

1988 • 229 citations

Premature translation termination mediates triosephosphate isomerase mRNA degradation.

1988 • 229 citations

Increased microtubule assembly in bovine brain tubulin lacking the type III isotype of beta-tubulin.

1990 • 222 citations

Two Drosophila beta tubulin isoforms are not functionally equivalent.

1990 • 212 citations

Dominant effects of tubulin overexpression in Saccharomyces cerevisiae.

1989 • 191 citations

Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.

1992 • 135 citations

Regulation of tubulin levels and microtubule assembly in Saccharomyces cerevisiae: consequences of altered tubulin gene copy number.

1990 • 132 citations

Phenotypic consequences of tubulin overproduction in Saccharomyces cerevisiae: differences between alpha-tubulin and beta-tubulin.

1990 • 131 citations

Intracellular sperm/egg interactions in Drosophila: A three-dimensional structural analysis of a paternal product in the developing egg

1991 • 128 citations

A 14 bp promoter element directs the testis specificity of the Drosophila beta 2 tubulin gene.

1989 • 125 citations

A dispersed multigene family encoding tubulin in Drosophila melanogaster

1980 • 120 citations

Preparation of a monoclonal antibody specific for the class IV isotype of beta-tubulin. Purification and assembly of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers from bovine brain.

1992 • 119 citations

Structural differences between brain beta 1- and beta 2-tubulins: implications for microtubule assembly and colchicine binding.

1985 • 110 citations

Three Drosophila Beta-Tubulin Sequences: A Developmentally Regulated Isoform (β 3), the Testis-Specific Isoform (β 2), and an Assembly-Defective Mutation of the Testis-Specific Isoform (B2T⁸) Reveal Both an Ancient Divergence in Metazoan Isotypes and Structural Constraints for Beta-Tubulin Function

1987 • 95 citations

Developmental distribution of RNA and protein products of the Drosophila α-tubulin gene family

1989 • 85 citations

A functionally specialized α-tubulin is required for oocyte meiosis and cleavage mitoses in Drosophila

1993 • 84 citations

Tissue-Specific Microtubule Functions in Drosophila Spermatogenesis Require the β2-Tubulin Isotype-Specific Carboxy Terminus

1993 • 83 citations

Characterization and structural aspects of the enhanced assembly of tubulin after removal of its carboxyl-terminal domain

1986 • 79 citations

Tissue-specific ecdysone responses: regulation of the Drosophila genes Eip28/29 and Eip40 during larval development

1992 • 71 citations

Three Drosophila beta-tubulin sequences: a developmentally regulated isoform (beta 3), the testis-specific isoform (beta 2), and an assembly-defective mutation of the testis-specific isoform (B2t8) reveal both an ancient divergence in metazoan isotypes and structural constraints for beta-tubulin function.

1987 • 68 citations

GENETIC ANALYSIS OF B2t, THE STRUCTURAL GENE FOR A TESTIS-SPECIFIC β-TUBULIN SUBUNIT IN DROSOPHILA MELANOGASTER

1983 • 67 citations

Genetic analysis of microtubule structure: a beta-tubulin mutation causes the formation of aberrant microtubules in vivo and in vitro.

1987 • 61 citations

A variant β-tubulin isoform of Drosophila melanogaster (β3) is expressed primarily in tissues of mesodermal origin in embryos and pupae, and is utilized in populations of transient microtubules

1989 • 60 citations

Mutations that encode partially functional beta 2 tubulin subunits have different effects on structurally different microtubule arrays.

1988 • 60 citations

Chromatin organization in the male germ line of Drosophila hydei

1986 • 59 citations

Testis-specific ?2 tubulins are identical in Drosophila melanogaster and D. hydei but differ from the ubiquitous ?1 tubulin

1987 • 56 citations

Analysis of β‐tubulin sequences reveals highly conserved, coordinated amino acid substitutions

1990 • 55 citations

Structural analysis of mutations in the Drosophila beta 2-tubulin isoform reveals regions in the beta-tubulin molecular required for general and for tissue-specific microtubule functions.

1995 • 51 citations

The beta 3-tubulin gene of Drosophila melanogaster is essential for viability and fertility.

1990 • 50 citations

Mutations Affecting Assembly and Stability of Tubulin: Evidence for a Nonessential β-Tubulin in Cho Cells

1987 • 50 citations

Gene regulation in Drosophila spermatogenesis: Analysis of protein binding at the translational control element TCE

1993 • 34 citations

Truncation of the carboxy-terminal domain of yeast beta-tubulin causes temperature-sensitive growth and hypersensitivity to antimitotic drugs [published erratum appears in J Cell Biol 1989 Feb;108(2):747]

1988 • 34 citations

During Drosophila spermatogenesis beta 1, beta 2 and beta 3 tubulin isotypes are cell-type specifically expressed but have the potential to coassemble into the axoneme of transgenic flies.

1991 • 33 citations

The Significance of the Sex Chromatin*

1966 • 31 citations

Tissue‐specific regulation by ecdysone: Distinct patterns of Eip28/29 expression are controlled by different ecdysone response elements

1994 • 27 citations

An 18-bp element in the 5' untranslated region of the Drosophila beta 2 tubulin mRNA regulates the mRNA level during postmeiotic stages of spermatogenesis.

1993 • 25 citations

Mutations affecting assembly and stability of tubulin: evidence for a nonessential beta-tubulin in CHO cells.

1987 • 24 citations

Polymorphic assembly of subtilisin‐cleaved tubulin

1987 • 23 citations

Deficiency in initiation factors of protein synthesis induced by phage T7 in E. coli F+ strains

1972 • 23 citations

Diverse expression of overlapping genes: The Drosophila Eip28/29 gene and its upstream neighbors

1989 • 23 citations

Further sequence requirements for male germ cell-specific expression under the control of the 14 bp promoter element (β2UE1) of theDrosophilaβ2 tubulin gene

1991 • 22 citations

Asymmetrically heteropycnotic X chromosomes in the grasshopper Melanoplus femur-rubrum

1978 • 18 citations

Mammalian-type dosage compensation mechanism in an insect —Gryllotalpa fossor (Scudder) — Orthoptera

1992 • 16 citations

Chromosomally derived sterile mice have a ?fertile? active XY chromatin conformation but no XY body

1989 • 13 citations

Undercondensation and localized euchromatinization of the X chromosome in the grasshopper Melanoplus femur-rubrum

1981 • 9 citations

Deleted Work

1955 • 0 citations