Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9

Molecular electrostatic potential of the nucleic acids

1981 • 408 citations

DNA sequence selectivity of guanine–N7 alkylation by nitrogen mustards

1986 • 233 citations

Reductase Enzyme Expression Across the National Cancer Institute Tumor Cell Line Panel: Correlation With Sensitivity to Mitomycin C and EO9

1996 • 232 citations

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

1990 • 222 citations

Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards

1987 • 178 citations

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in walker carcinoma cells

1988 • 167 citations

Bioreductive activation of mitomycin C by DT-diaphorase

1992 • 158 citations

Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells.

1990 • 128 citations

Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase.

1994 • 127 citations

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

1991 • 122 citations

An agarose gel method for the determination of DNA interstrand crosslinking applicable to the measurement of the rate of total and “second-arm” crosslink reactions

1991 • 109 citations

EO9: A novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models

1993 • 106 citations

Quantitative estimation of cisplatin-induced DNA interstrand cross-links and their repair in mammalian cells: Relationship to toxicity

1987 • 88 citations

Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

1994 • 76 citations

Phase I and Pharmacologic Study of the Novel Indoloquinone Bioreductive Alkylating Cytotoxic Drug E09

1994 • 73 citations

Unusually marked hypoxic sensitization to indoloquinone E09 and mitomycin C in a human colon‐tumour cell line that lacks DT‐diaphorase activity

1994 • 66 citations

DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9

1994 • 57 citations

Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes.

1995 • 56 citations

DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas

1992 • 54 citations

Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymic reduction by DT-diaphorase

1992 • 52 citations

Relative importance of DT-diaphorase and hypoxia in the bioactivation of e09 by human lung tumor cell lines

1994 • 52 citations

The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins

1992 • 43 citations

Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-β-en-α-ol (EO9) by human DT-diaphorase

1996 • 43 citations

A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: A study of the EORTC Early Clinical Studies Group (ECSG)

1996 • 43 citations

Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: Indoloquinones and diaziridinyl benzoquinones

1992 • 41 citations

Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression

1994 • 37 citations

Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase

1995 • 36 citations

DNA interstrand crosslinking and sequence selectivity of dimethanesulphonates

1991 • 34 citations

Walker carcinosarcoma 256 in study of anticancer agents. I. Method for simultaneous assessment of therapeutic value and toxicity.

1966 • 31 citations

EO9: relationship between DT-diaphorase levels and response in vitro and in vivo

1995 • 29 citations

The Walker 256 carcinoma: a cell type inherently sensitive only to those difunctional agents that can form DNA interstrand crosslinks

1991 • 19 citations

Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in walker cells

1989 • 15 citations